Patient-specific iPSC-derived cardiomyocytes reveal aberrant activation of Wnt/β-catenin signaling in SCN5A-related Brugada syndrome

BACKGROUND: Mutations in the cardiac sodium channel gene SCN5A cause Brugada syndrome (BrS), an arrhythmic disorder that is a leading cause of sudden death and lacks effective treatment. An association between SCN5A and Wnt/β-catenin signaling has been recently established. However, the role of Wnt/...

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Detalles Bibliográficos
Autores principales: Cai, Dongsheng, Wang, Xiaochen, Sun, Yaxun, Fan, Hangping, Zhou, Jingjun, Yang, Zongkuai, Qiu, Hangyuan, Wang, Jue, Su, Jun, Gong, Tingyu, Jiang, Chenyang, Liang, Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10486057/
https://www.ncbi.nlm.nih.gov/pubmed/37679791
http://dx.doi.org/10.1186/s13287-023-03477-3

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