Sildenafil, a phosphodiesterase-5 inhibitor, stimulates angiogenesis and bone regeneration in an atrophic non-union model in mice

Non-union formation represents a major complication in trauma and orthopedic surgery. The phosphodiesterase-5 (PDE-5) inhibitor sildenafil has been shown to exert pro-angiogenic and pro-osteogenic effects in vitro and in vivo. Therefore, the aim of the present study was to analyze the impact of sild...

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Detalles Bibliográficos
Autores principales: Menger, Maximilian M., Bauer, David, Bleimehl, Michelle, Scheuer, Claudia, Braun, Benedikt J., Herath, Steven C., Rollmann, Mika F., Menger, Michael D., Laschke, Matthias W., Histing, Tina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10486066/
https://www.ncbi.nlm.nih.gov/pubmed/37684656
http://dx.doi.org/10.1186/s12967-023-04441-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10486066/
https://www.ncbi.nlm.nih.gov/pubmed/37684656
http://dx.doi.org/10.1186/s12967-023-04441-8

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