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Sildenafil, a phosphodiesterase-5 inhibitor, stimulates angiogenesis and bone regeneration in an atrophic non-union model in mice
Non-union formation represents a major complication in trauma and orthopedic surgery. The phosphodiesterase-5 (PDE-5) inhibitor sildenafil has been shown to exert pro-angiogenic and pro-osteogenic effects in vitro and in vivo. Therefore, the aim of the present study was to analyze the impact of sild...
Autores principales: | Menger, Maximilian M., Bauer, David, Bleimehl, Michelle, Scheuer, Claudia, Braun, Benedikt J., Herath, Steven C., Rollmann, Mika F., Menger, Michael D., Laschke, Matthias W., Histing, Tina |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10486066/ https://www.ncbi.nlm.nih.gov/pubmed/37684656 http://dx.doi.org/10.1186/s12967-023-04441-8 |
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