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Sinopharm (HB02)-associated vaccine-induced immune thrombotic thrombocytopenia: a case report
BACKGROUND: Vaccine-induced thrombotic thrombocytopenia is associated with the coronavirus disease 2019 vaccines. It has been reported by vector-based vaccines. To the best of our knowledge, there is no report about vaccine-induced thrombotic thrombocytopenia in whole-virus vaccines. We are presenti...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10486117/ https://www.ncbi.nlm.nih.gov/pubmed/37679815 http://dx.doi.org/10.1186/s13256-023-04086-7 |
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author | Sistanizad, Mohammad Sabaghian, Tahereh Amini, Hossein Hadavand, Fahimeh Nabavi, Mahmood Kouchek, Mehran Miri, Mir Mohammad Salarian, Sara Shojaei, Seyedpouzhia Moradi, Omid |
author_facet | Sistanizad, Mohammad Sabaghian, Tahereh Amini, Hossein Hadavand, Fahimeh Nabavi, Mahmood Kouchek, Mehran Miri, Mir Mohammad Salarian, Sara Shojaei, Seyedpouzhia Moradi, Omid |
author_sort | Sistanizad, Mohammad |
collection | PubMed |
description | BACKGROUND: Vaccine-induced thrombotic thrombocytopenia is associated with the coronavirus disease 2019 vaccines. It has been reported by vector-based vaccines. To the best of our knowledge, there is no report about vaccine-induced thrombotic thrombocytopenia in whole-virus vaccines. We are presenting the first case of vaccine-induced thrombotic thrombocytopenia with this type of vaccine. CASE PRESENTATION: An 18-year-old male Caucasian patient with complaints of severe abdominal, low back, and lower extremity pain presented to the medical center. He received the first dose of the Sinopharm (HB02) vaccine against coronavirus disease 2019 10 days before hospital attendance. In the laboratory examination, decreased platelet count and increased D-dimer were observed. During hospital admission, the diagnosis of pulmonary embolism was reached. He received vaccine-induced thrombotic thrombocytopenia therapy consisting of intravenous immune globulin and direct oral anticoagulant. Platelet count increased and he was discharged after 1 month. CONCLUSION: This case highlights the possibility of vaccine-induced thrombotic thrombocytopenia occurrence by whole-virus coronavirus disease 2019 vaccines. Compared with vector-based vaccines, this phenomenon is rare for whole-virus vaccines. More studies on this type of vaccine regarding thrombotic thrombocytopenia should be considered. |
format | Online Article Text |
id | pubmed-10486117 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-104861172023-09-09 Sinopharm (HB02)-associated vaccine-induced immune thrombotic thrombocytopenia: a case report Sistanizad, Mohammad Sabaghian, Tahereh Amini, Hossein Hadavand, Fahimeh Nabavi, Mahmood Kouchek, Mehran Miri, Mir Mohammad Salarian, Sara Shojaei, Seyedpouzhia Moradi, Omid J Med Case Rep Case Report BACKGROUND: Vaccine-induced thrombotic thrombocytopenia is associated with the coronavirus disease 2019 vaccines. It has been reported by vector-based vaccines. To the best of our knowledge, there is no report about vaccine-induced thrombotic thrombocytopenia in whole-virus vaccines. We are presenting the first case of vaccine-induced thrombotic thrombocytopenia with this type of vaccine. CASE PRESENTATION: An 18-year-old male Caucasian patient with complaints of severe abdominal, low back, and lower extremity pain presented to the medical center. He received the first dose of the Sinopharm (HB02) vaccine against coronavirus disease 2019 10 days before hospital attendance. In the laboratory examination, decreased platelet count and increased D-dimer were observed. During hospital admission, the diagnosis of pulmonary embolism was reached. He received vaccine-induced thrombotic thrombocytopenia therapy consisting of intravenous immune globulin and direct oral anticoagulant. Platelet count increased and he was discharged after 1 month. CONCLUSION: This case highlights the possibility of vaccine-induced thrombotic thrombocytopenia occurrence by whole-virus coronavirus disease 2019 vaccines. Compared with vector-based vaccines, this phenomenon is rare for whole-virus vaccines. More studies on this type of vaccine regarding thrombotic thrombocytopenia should be considered. BioMed Central 2023-09-08 /pmc/articles/PMC10486117/ /pubmed/37679815 http://dx.doi.org/10.1186/s13256-023-04086-7 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Case Report Sistanizad, Mohammad Sabaghian, Tahereh Amini, Hossein Hadavand, Fahimeh Nabavi, Mahmood Kouchek, Mehran Miri, Mir Mohammad Salarian, Sara Shojaei, Seyedpouzhia Moradi, Omid Sinopharm (HB02)-associated vaccine-induced immune thrombotic thrombocytopenia: a case report |
title | Sinopharm (HB02)-associated vaccine-induced immune thrombotic thrombocytopenia: a case report |
title_full | Sinopharm (HB02)-associated vaccine-induced immune thrombotic thrombocytopenia: a case report |
title_fullStr | Sinopharm (HB02)-associated vaccine-induced immune thrombotic thrombocytopenia: a case report |
title_full_unstemmed | Sinopharm (HB02)-associated vaccine-induced immune thrombotic thrombocytopenia: a case report |
title_short | Sinopharm (HB02)-associated vaccine-induced immune thrombotic thrombocytopenia: a case report |
title_sort | sinopharm (hb02)-associated vaccine-induced immune thrombotic thrombocytopenia: a case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10486117/ https://www.ncbi.nlm.nih.gov/pubmed/37679815 http://dx.doi.org/10.1186/s13256-023-04086-7 |
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