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A standardised protocol for relative SARS-CoV-2 variant severity assessment, applied to Omicron BA.1 and Delta in six European countries, October 2021 to February 2022

Several SARS-CoV-2 variants that evolved during the COVID-19 pandemic have appeared to differ in severity, based on analyses of single-country datasets. With decreased testing and sequencing, international collaborative studies will become increasingly important for timely assessment of the severity...

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Autores principales: Nyberg, Tommy, Bager, Peter, Svalgaard, Ingrid Bech, Bejko, Dritan, Bundle, Nick, Evans, Josie, Krause, Tyra Grove, McMenamin, Jim, Mossong, Joël, Mutch, Heather, Omokanye, Ajibola, Peralta-Santos, André, Pinto-Leite, Pedro, Starrfelt, Jostein, Thelwall, Simon, Veneti, Lamprini, Whittaker, Robert, Wood, John, Pebody, Richard, Presanis, Anne M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Centre for Disease Prevention and Control (ECDC) 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10486193/
https://www.ncbi.nlm.nih.gov/pubmed/37676146
http://dx.doi.org/10.2807/1560-7917.ES.2023.28.36.2300048
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author Nyberg, Tommy
Bager, Peter
Svalgaard, Ingrid Bech
Bejko, Dritan
Bundle, Nick
Evans, Josie
Krause, Tyra Grove
McMenamin, Jim
Mossong, Joël
Mutch, Heather
Omokanye, Ajibola
Peralta-Santos, André
Pinto-Leite, Pedro
Starrfelt, Jostein
Thelwall, Simon
Veneti, Lamprini
Whittaker, Robert
Wood, John
Pebody, Richard
Presanis, Anne M
author_facet Nyberg, Tommy
Bager, Peter
Svalgaard, Ingrid Bech
Bejko, Dritan
Bundle, Nick
Evans, Josie
Krause, Tyra Grove
McMenamin, Jim
Mossong, Joël
Mutch, Heather
Omokanye, Ajibola
Peralta-Santos, André
Pinto-Leite, Pedro
Starrfelt, Jostein
Thelwall, Simon
Veneti, Lamprini
Whittaker, Robert
Wood, John
Pebody, Richard
Presanis, Anne M
author_sort Nyberg, Tommy
collection PubMed
description Several SARS-CoV-2 variants that evolved during the COVID-19 pandemic have appeared to differ in severity, based on analyses of single-country datasets. With decreased testing and sequencing, international collaborative studies will become increasingly important for timely assessment of the severity of new variants. Therefore, a joint WHO Regional Office for Europe and ECDC working group was formed to produce and pilot a standardised study protocol to estimate relative case-severity of SARS-CoV-2 variants during periods when two variants were co-circulating. The study protocol and its associated statistical analysis code was applied by investigators in Denmark, England, Luxembourg, Norway, Portugal and Scotland to assess the severity of cases with the Omicron BA.1 virus variant relative to Delta. After pooling estimates using meta-analysis methods (random effects estimates), the risk of hospital admission (adjusted hazard ratio (aHR) = 0.41; 95% confidence interval (CI): 0.31−0.54), admission to intensive care unit (aHR = 0.12; 95% CI: 0.05−0.27) and death (aHR = 0.31; 95% CI: 0.28−0.35) was lower for Omicron BA.1 compared with Delta cases. The aHRs varied by age group and vaccination status. In conclusion, this study demonstrates the feasibility of conducting variant severity analyses in a multinational collaborative framework and adds evidence for the reduced severity of the Omicron BA.1 variant.
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spelling pubmed-104861932023-09-09 A standardised protocol for relative SARS-CoV-2 variant severity assessment, applied to Omicron BA.1 and Delta in six European countries, October 2021 to February 2022 Nyberg, Tommy Bager, Peter Svalgaard, Ingrid Bech Bejko, Dritan Bundle, Nick Evans, Josie Krause, Tyra Grove McMenamin, Jim Mossong, Joël Mutch, Heather Omokanye, Ajibola Peralta-Santos, André Pinto-Leite, Pedro Starrfelt, Jostein Thelwall, Simon Veneti, Lamprini Whittaker, Robert Wood, John Pebody, Richard Presanis, Anne M Euro Surveill Euroroundup Several SARS-CoV-2 variants that evolved during the COVID-19 pandemic have appeared to differ in severity, based on analyses of single-country datasets. With decreased testing and sequencing, international collaborative studies will become increasingly important for timely assessment of the severity of new variants. Therefore, a joint WHO Regional Office for Europe and ECDC working group was formed to produce and pilot a standardised study protocol to estimate relative case-severity of SARS-CoV-2 variants during periods when two variants were co-circulating. The study protocol and its associated statistical analysis code was applied by investigators in Denmark, England, Luxembourg, Norway, Portugal and Scotland to assess the severity of cases with the Omicron BA.1 virus variant relative to Delta. After pooling estimates using meta-analysis methods (random effects estimates), the risk of hospital admission (adjusted hazard ratio (aHR) = 0.41; 95% confidence interval (CI): 0.31−0.54), admission to intensive care unit (aHR = 0.12; 95% CI: 0.05−0.27) and death (aHR = 0.31; 95% CI: 0.28−0.35) was lower for Omicron BA.1 compared with Delta cases. The aHRs varied by age group and vaccination status. In conclusion, this study demonstrates the feasibility of conducting variant severity analyses in a multinational collaborative framework and adds evidence for the reduced severity of the Omicron BA.1 variant. European Centre for Disease Prevention and Control (ECDC) 2023-09-07 /pmc/articles/PMC10486193/ /pubmed/37676146 http://dx.doi.org/10.2807/1560-7917.ES.2023.28.36.2300048 Text en This article is copyright of the authors or their affiliated institutions, 2023. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made.
spellingShingle Euroroundup
Nyberg, Tommy
Bager, Peter
Svalgaard, Ingrid Bech
Bejko, Dritan
Bundle, Nick
Evans, Josie
Krause, Tyra Grove
McMenamin, Jim
Mossong, Joël
Mutch, Heather
Omokanye, Ajibola
Peralta-Santos, André
Pinto-Leite, Pedro
Starrfelt, Jostein
Thelwall, Simon
Veneti, Lamprini
Whittaker, Robert
Wood, John
Pebody, Richard
Presanis, Anne M
A standardised protocol for relative SARS-CoV-2 variant severity assessment, applied to Omicron BA.1 and Delta in six European countries, October 2021 to February 2022
title A standardised protocol for relative SARS-CoV-2 variant severity assessment, applied to Omicron BA.1 and Delta in six European countries, October 2021 to February 2022
title_full A standardised protocol for relative SARS-CoV-2 variant severity assessment, applied to Omicron BA.1 and Delta in six European countries, October 2021 to February 2022
title_fullStr A standardised protocol for relative SARS-CoV-2 variant severity assessment, applied to Omicron BA.1 and Delta in six European countries, October 2021 to February 2022
title_full_unstemmed A standardised protocol for relative SARS-CoV-2 variant severity assessment, applied to Omicron BA.1 and Delta in six European countries, October 2021 to February 2022
title_short A standardised protocol for relative SARS-CoV-2 variant severity assessment, applied to Omicron BA.1 and Delta in six European countries, October 2021 to February 2022
title_sort standardised protocol for relative sars-cov-2 variant severity assessment, applied to omicron ba.1 and delta in six european countries, october 2021 to february 2022
topic Euroroundup
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10486193/
https://www.ncbi.nlm.nih.gov/pubmed/37676146
http://dx.doi.org/10.2807/1560-7917.ES.2023.28.36.2300048
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