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Effect of non-enzymatic glycation on collagen nanoscale mechanisms in diabetic and age-related bone fragility

Age and diabetes have long been known to induce an oxidative reaction between glucose and collagen, leading to the accumulation of advanced glycation end-products (AGEs) cross-links in collagenous tissues. More recently, AGEs content has been related to loss of bone quality, independent of bone mass...

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Autores principales: ROSENBERG, James L., WOOLLEY, William, ELNUNU, Ihsan, KAMML, Julia, KAMMER, David S., ACEVEDO, Claire
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10486207/
https://www.ncbi.nlm.nih.gov/pubmed/37693278
http://dx.doi.org/10.32604/biocell.2023.028014
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author ROSENBERG, James L.
WOOLLEY, William
ELNUNU, Ihsan
KAMML, Julia
KAMMER, David S.
ACEVEDO, Claire
author_facet ROSENBERG, James L.
WOOLLEY, William
ELNUNU, Ihsan
KAMML, Julia
KAMMER, David S.
ACEVEDO, Claire
author_sort ROSENBERG, James L.
collection PubMed
description Age and diabetes have long been known to induce an oxidative reaction between glucose and collagen, leading to the accumulation of advanced glycation end-products (AGEs) cross-links in collagenous tissues. More recently, AGEs content has been related to loss of bone quality, independent of bone mass, and increased fracture risk with aging and diabetes. Loss of bone quality is mostly attributed to changes in material properties, structural organization, or cellular remodeling. Though all these factors play a role in bone fragility disease, some common recurring patterns can be found between diabetic and age-related bone fragility. The main pattern we will discuss in this viewpoint is the increase of fibrillar collagen stiffness and loss of collagen-induced plasticity with AGE accumulation. This study focused on recent related experimental studies and discusses the correlation between fluorescent AGEs content at the molecular and fibrillar scales, collagen deformation mechanisms at the nanoscale, and resistance to bone fracture at the macroscale.
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spelling pubmed-104862072023-09-08 Effect of non-enzymatic glycation on collagen nanoscale mechanisms in diabetic and age-related bone fragility ROSENBERG, James L. WOOLLEY, William ELNUNU, Ihsan KAMML, Julia KAMMER, David S. ACEVEDO, Claire Biocell Article Age and diabetes have long been known to induce an oxidative reaction between glucose and collagen, leading to the accumulation of advanced glycation end-products (AGEs) cross-links in collagenous tissues. More recently, AGEs content has been related to loss of bone quality, independent of bone mass, and increased fracture risk with aging and diabetes. Loss of bone quality is mostly attributed to changes in material properties, structural organization, or cellular remodeling. Though all these factors play a role in bone fragility disease, some common recurring patterns can be found between diabetic and age-related bone fragility. The main pattern we will discuss in this viewpoint is the increase of fibrillar collagen stiffness and loss of collagen-induced plasticity with AGE accumulation. This study focused on recent related experimental studies and discusses the correlation between fluorescent AGEs content at the molecular and fibrillar scales, collagen deformation mechanisms at the nanoscale, and resistance to bone fracture at the macroscale. 2023-06-21 /pmc/articles/PMC10486207/ /pubmed/37693278 http://dx.doi.org/10.32604/biocell.2023.028014 Text en https://creativecommons.org/licenses/by/4.0/This work is licensed under a Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Article
ROSENBERG, James L.
WOOLLEY, William
ELNUNU, Ihsan
KAMML, Julia
KAMMER, David S.
ACEVEDO, Claire
Effect of non-enzymatic glycation on collagen nanoscale mechanisms in diabetic and age-related bone fragility
title Effect of non-enzymatic glycation on collagen nanoscale mechanisms in diabetic and age-related bone fragility
title_full Effect of non-enzymatic glycation on collagen nanoscale mechanisms in diabetic and age-related bone fragility
title_fullStr Effect of non-enzymatic glycation on collagen nanoscale mechanisms in diabetic and age-related bone fragility
title_full_unstemmed Effect of non-enzymatic glycation on collagen nanoscale mechanisms in diabetic and age-related bone fragility
title_short Effect of non-enzymatic glycation on collagen nanoscale mechanisms in diabetic and age-related bone fragility
title_sort effect of non-enzymatic glycation on collagen nanoscale mechanisms in diabetic and age-related bone fragility
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10486207/
https://www.ncbi.nlm.nih.gov/pubmed/37693278
http://dx.doi.org/10.32604/biocell.2023.028014
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