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Recent advances in lipid nanovesicles for targeted treatment of spinal cord injury

The effective regeneration and functional restoration of damaged spinal cord tissue have been a long-standing concern in regenerative medicine. Treatment of spinal cord injury (SCI) is challenging due to the obstruction of the blood-spinal cord barrier (BSCB), the lack of targeting of drugs, and the...

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Autores principales: Lu, Di, Wu, Jiu-Ping, Yang, Qi-Wei, Wang, Hua-Yi, Yang, Jun-Jie, Zhang, Gang-Gang, Wang, Chen, Yang, Yan-Lian, Zhu, Ling, Sun, Xin-Zhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10486273/
https://www.ncbi.nlm.nih.gov/pubmed/37691909
http://dx.doi.org/10.3389/fbioe.2023.1261288
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author Lu, Di
Wu, Jiu-Ping
Yang, Qi-Wei
Wang, Hua-Yi
Yang, Jun-Jie
Zhang, Gang-Gang
Wang, Chen
Yang, Yan-Lian
Zhu, Ling
Sun, Xin-Zhi
author_facet Lu, Di
Wu, Jiu-Ping
Yang, Qi-Wei
Wang, Hua-Yi
Yang, Jun-Jie
Zhang, Gang-Gang
Wang, Chen
Yang, Yan-Lian
Zhu, Ling
Sun, Xin-Zhi
author_sort Lu, Di
collection PubMed
description The effective regeneration and functional restoration of damaged spinal cord tissue have been a long-standing concern in regenerative medicine. Treatment of spinal cord injury (SCI) is challenging due to the obstruction of the blood-spinal cord barrier (BSCB), the lack of targeting of drugs, and the complex pathophysiology of injury sites. Lipid nanovesicles, including cell-derived nanovesicles and synthetic lipid nanovesicles, are highly biocompatible and can penetrate BSCB, and are therefore effective delivery systems for targeted treatment of SCI. We summarize the progress of lipid nanovesicles for the targeted treatment of SCI, discuss their advantages and challenges, and provide a perspective on the application of lipid nanovesicles for SCI treatment. Although most of the lipid nanovesicle-based therapy of SCI is still in preclinical studies, this low immunogenicity, low toxicity, and highly engineerable nanovesicles will hold great promise for future spinal cord injury treatments.
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spelling pubmed-104862732023-09-09 Recent advances in lipid nanovesicles for targeted treatment of spinal cord injury Lu, Di Wu, Jiu-Ping Yang, Qi-Wei Wang, Hua-Yi Yang, Jun-Jie Zhang, Gang-Gang Wang, Chen Yang, Yan-Lian Zhu, Ling Sun, Xin-Zhi Front Bioeng Biotechnol Bioengineering and Biotechnology The effective regeneration and functional restoration of damaged spinal cord tissue have been a long-standing concern in regenerative medicine. Treatment of spinal cord injury (SCI) is challenging due to the obstruction of the blood-spinal cord barrier (BSCB), the lack of targeting of drugs, and the complex pathophysiology of injury sites. Lipid nanovesicles, including cell-derived nanovesicles and synthetic lipid nanovesicles, are highly biocompatible and can penetrate BSCB, and are therefore effective delivery systems for targeted treatment of SCI. We summarize the progress of lipid nanovesicles for the targeted treatment of SCI, discuss their advantages and challenges, and provide a perspective on the application of lipid nanovesicles for SCI treatment. Although most of the lipid nanovesicle-based therapy of SCI is still in preclinical studies, this low immunogenicity, low toxicity, and highly engineerable nanovesicles will hold great promise for future spinal cord injury treatments. Frontiers Media S.A. 2023-08-16 /pmc/articles/PMC10486273/ /pubmed/37691909 http://dx.doi.org/10.3389/fbioe.2023.1261288 Text en Copyright © 2023 Lu, Wu, Yang, Wang, Yang, Zhang, Wang, Yang, Zhu and Sun. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Bioengineering and Biotechnology
Lu, Di
Wu, Jiu-Ping
Yang, Qi-Wei
Wang, Hua-Yi
Yang, Jun-Jie
Zhang, Gang-Gang
Wang, Chen
Yang, Yan-Lian
Zhu, Ling
Sun, Xin-Zhi
Recent advances in lipid nanovesicles for targeted treatment of spinal cord injury
title Recent advances in lipid nanovesicles for targeted treatment of spinal cord injury
title_full Recent advances in lipid nanovesicles for targeted treatment of spinal cord injury
title_fullStr Recent advances in lipid nanovesicles for targeted treatment of spinal cord injury
title_full_unstemmed Recent advances in lipid nanovesicles for targeted treatment of spinal cord injury
title_short Recent advances in lipid nanovesicles for targeted treatment of spinal cord injury
title_sort recent advances in lipid nanovesicles for targeted treatment of spinal cord injury
topic Bioengineering and Biotechnology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10486273/
https://www.ncbi.nlm.nih.gov/pubmed/37691909
http://dx.doi.org/10.3389/fbioe.2023.1261288
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