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Recent advances in lipid nanovesicles for targeted treatment of spinal cord injury
The effective regeneration and functional restoration of damaged spinal cord tissue have been a long-standing concern in regenerative medicine. Treatment of spinal cord injury (SCI) is challenging due to the obstruction of the blood-spinal cord barrier (BSCB), the lack of targeting of drugs, and the...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10486273/ https://www.ncbi.nlm.nih.gov/pubmed/37691909 http://dx.doi.org/10.3389/fbioe.2023.1261288 |
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author | Lu, Di Wu, Jiu-Ping Yang, Qi-Wei Wang, Hua-Yi Yang, Jun-Jie Zhang, Gang-Gang Wang, Chen Yang, Yan-Lian Zhu, Ling Sun, Xin-Zhi |
author_facet | Lu, Di Wu, Jiu-Ping Yang, Qi-Wei Wang, Hua-Yi Yang, Jun-Jie Zhang, Gang-Gang Wang, Chen Yang, Yan-Lian Zhu, Ling Sun, Xin-Zhi |
author_sort | Lu, Di |
collection | PubMed |
description | The effective regeneration and functional restoration of damaged spinal cord tissue have been a long-standing concern in regenerative medicine. Treatment of spinal cord injury (SCI) is challenging due to the obstruction of the blood-spinal cord barrier (BSCB), the lack of targeting of drugs, and the complex pathophysiology of injury sites. Lipid nanovesicles, including cell-derived nanovesicles and synthetic lipid nanovesicles, are highly biocompatible and can penetrate BSCB, and are therefore effective delivery systems for targeted treatment of SCI. We summarize the progress of lipid nanovesicles for the targeted treatment of SCI, discuss their advantages and challenges, and provide a perspective on the application of lipid nanovesicles for SCI treatment. Although most of the lipid nanovesicle-based therapy of SCI is still in preclinical studies, this low immunogenicity, low toxicity, and highly engineerable nanovesicles will hold great promise for future spinal cord injury treatments. |
format | Online Article Text |
id | pubmed-10486273 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-104862732023-09-09 Recent advances in lipid nanovesicles for targeted treatment of spinal cord injury Lu, Di Wu, Jiu-Ping Yang, Qi-Wei Wang, Hua-Yi Yang, Jun-Jie Zhang, Gang-Gang Wang, Chen Yang, Yan-Lian Zhu, Ling Sun, Xin-Zhi Front Bioeng Biotechnol Bioengineering and Biotechnology The effective regeneration and functional restoration of damaged spinal cord tissue have been a long-standing concern in regenerative medicine. Treatment of spinal cord injury (SCI) is challenging due to the obstruction of the blood-spinal cord barrier (BSCB), the lack of targeting of drugs, and the complex pathophysiology of injury sites. Lipid nanovesicles, including cell-derived nanovesicles and synthetic lipid nanovesicles, are highly biocompatible and can penetrate BSCB, and are therefore effective delivery systems for targeted treatment of SCI. We summarize the progress of lipid nanovesicles for the targeted treatment of SCI, discuss their advantages and challenges, and provide a perspective on the application of lipid nanovesicles for SCI treatment. Although most of the lipid nanovesicle-based therapy of SCI is still in preclinical studies, this low immunogenicity, low toxicity, and highly engineerable nanovesicles will hold great promise for future spinal cord injury treatments. Frontiers Media S.A. 2023-08-16 /pmc/articles/PMC10486273/ /pubmed/37691909 http://dx.doi.org/10.3389/fbioe.2023.1261288 Text en Copyright © 2023 Lu, Wu, Yang, Wang, Yang, Zhang, Wang, Yang, Zhu and Sun. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Bioengineering and Biotechnology Lu, Di Wu, Jiu-Ping Yang, Qi-Wei Wang, Hua-Yi Yang, Jun-Jie Zhang, Gang-Gang Wang, Chen Yang, Yan-Lian Zhu, Ling Sun, Xin-Zhi Recent advances in lipid nanovesicles for targeted treatment of spinal cord injury |
title | Recent advances in lipid nanovesicles for targeted treatment of spinal cord injury |
title_full | Recent advances in lipid nanovesicles for targeted treatment of spinal cord injury |
title_fullStr | Recent advances in lipid nanovesicles for targeted treatment of spinal cord injury |
title_full_unstemmed | Recent advances in lipid nanovesicles for targeted treatment of spinal cord injury |
title_short | Recent advances in lipid nanovesicles for targeted treatment of spinal cord injury |
title_sort | recent advances in lipid nanovesicles for targeted treatment of spinal cord injury |
topic | Bioengineering and Biotechnology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10486273/ https://www.ncbi.nlm.nih.gov/pubmed/37691909 http://dx.doi.org/10.3389/fbioe.2023.1261288 |
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