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Lamotrigine compromises the fidelity of initiator tRNA recruitment to the ribosomal P-site by IF2 and the RbfA release from 30S ribosomes in Escherichia coli

Lamotrigine (Ltg), an anticonvulsant drug, targets initiation factor 2 (IF2), compromises ribosome biogenesis and causes toxicity to Escherichia coli. However, our understanding of Ltg toxicity in E. coli remains unclear. While our in vitro assays reveal no effects of Ltg on the ribosome-dependent G...

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Detalles Bibliográficos
Autores principales:	Singh, Sudhir, Lahry, Kuldeep, Mandava, Chandra Sekhar, Singh, Jitendra, Shah, Riyaz Ahmad, Sanyal, Suparna, Varshney, Umesh
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2023
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10486304/ https://www.ncbi.nlm.nih.gov/pubmed/37676049 http://dx.doi.org/10.1080/15476286.2023.2253395

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