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UHFUS: A Valuable Tool in Evaluating Exocrine Gland Abnormalities in Sjögren’s Disease

Sjögren’s Disease (SjD) is a chronic autoimmune disorder that affects the salivary and lacrimal glands, leading to xerostomia and xerophthalmia. Ultrasonography of Major Salivary Glands (SGUS) is a well-established tool for the identification of the salivary glands’ abnormalities in SjD. Recently, a...

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Autores principales: Fulvio, Giovanni, Izzetti, Rossana, Aringhieri, Giacomo, Donati, Valentina, Ferro, Francesco, Gabbriellini, Giovanna, Mosca, Marta, Baldini, Chiara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10486364/
https://www.ncbi.nlm.nih.gov/pubmed/37685309
http://dx.doi.org/10.3390/diagnostics13172771
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author Fulvio, Giovanni
Izzetti, Rossana
Aringhieri, Giacomo
Donati, Valentina
Ferro, Francesco
Gabbriellini, Giovanna
Mosca, Marta
Baldini, Chiara
author_facet Fulvio, Giovanni
Izzetti, Rossana
Aringhieri, Giacomo
Donati, Valentina
Ferro, Francesco
Gabbriellini, Giovanna
Mosca, Marta
Baldini, Chiara
author_sort Fulvio, Giovanni
collection PubMed
description Sjögren’s Disease (SjD) is a chronic autoimmune disorder that affects the salivary and lacrimal glands, leading to xerostomia and xerophthalmia. Ultrasonography of Major Salivary Glands (SGUS) is a well-established tool for the identification of the salivary glands’ abnormalities in SjD. Recently, a growing interest has arisen in the assessment of the other exocrine glands with ultrasonography: lacrimal glands (LGUS) and labial salivary glands (LSGUS). The objective of this study is to explore the practical applications of ultra-high frequency ultrasound (UHFUS) in the assessment of lacrimal glands and labial salivary glands. Indeed, UHFUS, with its improved spatial resolution compared to conventional ultrasonography, allows for the evaluation of microscopic structures and has been successfully applied in various medical fields. In lacrimal glands, conventional high-frequency ultrasound (HFUS) can detect characteristic inflammatory changes, atrophic alterations, blood flow patterns, and neoplastic lesions associated with SjD. However, sometimes it is challenging to identify lacrimal glands characteristics, thus making UHFUS a promising tool. Regarding labial salivary glands, limited research is available with conventional HFUS, but UHFUS proves to be a good tool to evaluate glandular inhomogeneity and to guide labial salivary glands biopsy. The comprehensive understanding of organ involvement facilitated by UHFUS may significantly improve the management of SjD patients.
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spelling pubmed-104863642023-09-09 UHFUS: A Valuable Tool in Evaluating Exocrine Gland Abnormalities in Sjögren’s Disease Fulvio, Giovanni Izzetti, Rossana Aringhieri, Giacomo Donati, Valentina Ferro, Francesco Gabbriellini, Giovanna Mosca, Marta Baldini, Chiara Diagnostics (Basel) Brief Report Sjögren’s Disease (SjD) is a chronic autoimmune disorder that affects the salivary and lacrimal glands, leading to xerostomia and xerophthalmia. Ultrasonography of Major Salivary Glands (SGUS) is a well-established tool for the identification of the salivary glands’ abnormalities in SjD. Recently, a growing interest has arisen in the assessment of the other exocrine glands with ultrasonography: lacrimal glands (LGUS) and labial salivary glands (LSGUS). The objective of this study is to explore the practical applications of ultra-high frequency ultrasound (UHFUS) in the assessment of lacrimal glands and labial salivary glands. Indeed, UHFUS, with its improved spatial resolution compared to conventional ultrasonography, allows for the evaluation of microscopic structures and has been successfully applied in various medical fields. In lacrimal glands, conventional high-frequency ultrasound (HFUS) can detect characteristic inflammatory changes, atrophic alterations, blood flow patterns, and neoplastic lesions associated with SjD. However, sometimes it is challenging to identify lacrimal glands characteristics, thus making UHFUS a promising tool. Regarding labial salivary glands, limited research is available with conventional HFUS, but UHFUS proves to be a good tool to evaluate glandular inhomogeneity and to guide labial salivary glands biopsy. The comprehensive understanding of organ involvement facilitated by UHFUS may significantly improve the management of SjD patients. MDPI 2023-08-26 /pmc/articles/PMC10486364/ /pubmed/37685309 http://dx.doi.org/10.3390/diagnostics13172771 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Brief Report
Fulvio, Giovanni
Izzetti, Rossana
Aringhieri, Giacomo
Donati, Valentina
Ferro, Francesco
Gabbriellini, Giovanna
Mosca, Marta
Baldini, Chiara
UHFUS: A Valuable Tool in Evaluating Exocrine Gland Abnormalities in Sjögren’s Disease
title UHFUS: A Valuable Tool in Evaluating Exocrine Gland Abnormalities in Sjögren’s Disease
title_full UHFUS: A Valuable Tool in Evaluating Exocrine Gland Abnormalities in Sjögren’s Disease
title_fullStr UHFUS: A Valuable Tool in Evaluating Exocrine Gland Abnormalities in Sjögren’s Disease
title_full_unstemmed UHFUS: A Valuable Tool in Evaluating Exocrine Gland Abnormalities in Sjögren’s Disease
title_short UHFUS: A Valuable Tool in Evaluating Exocrine Gland Abnormalities in Sjögren’s Disease
title_sort uhfus: a valuable tool in evaluating exocrine gland abnormalities in sjögren’s disease
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10486364/
https://www.ncbi.nlm.nih.gov/pubmed/37685309
http://dx.doi.org/10.3390/diagnostics13172771
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