A Network Landscape of HPVOPC Reveals Methylation Alterations as Significant Drivers of Gene Expression via an Immune-Mediated GPCR Signal

SIMPLE SUMMARY: In this manuscript, we demonstrated a particular chemokine axis (CXCR3/CXCL9,10,11) to be highly expressed in HPV-associated oropharynx carcinoma (HPVOPC). This classically paracrine chemokine axis is thought to play an anti-tumor role through immune surveillance and tumor suppressio...

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Detalles Bibliográficos
Autores principales: Qualliotine, Jesse R., Nakagawa, Takuya, Rosenthal, Sara Brin, Sadat, Sayed, Ballesteros-Merino, Carmen, Xu, Guorong, Mark, Adam, Nasamran, Art, Gutkind, J. Silvio, Fisch, Kathleen M., Guo, Theresa, Fox, Bernard A., Khan, Zubair, Molinolo, Alfredo A., Califano, Joseph A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10486378/
https://www.ncbi.nlm.nih.gov/pubmed/37686653
http://dx.doi.org/10.3390/cancers15174379

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