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Insights into the Function of Aquaporins in Gastrointestinal Fluid Absorption and Secretion in Health and Disease
Aquaporins (AQPs), transmembrane proteins permeable to water, are involved in gastrointestinal secretion. The secretory products of the glands are delivered either to some organ cavities for exocrine glands or to the bloodstream for endocrine glands. The main secretory glands being part of the gastr...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10486417/ https://www.ncbi.nlm.nih.gov/pubmed/37681902 http://dx.doi.org/10.3390/cells12172170 |
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author | Calamita, Giuseppe Delporte, Christine |
author_facet | Calamita, Giuseppe Delporte, Christine |
author_sort | Calamita, Giuseppe |
collection | PubMed |
description | Aquaporins (AQPs), transmembrane proteins permeable to water, are involved in gastrointestinal secretion. The secretory products of the glands are delivered either to some organ cavities for exocrine glands or to the bloodstream for endocrine glands. The main secretory glands being part of the gastrointestinal system are salivary glands, gastric glands, duodenal Brunner’s gland, liver, bile ducts, gallbladder, intestinal goblet cells, exocrine and endocrine pancreas. Due to their expression in gastrointestinal exocrine and endocrine glands, AQPs fulfill important roles in the secretion of various fluids involved in food handling. This review summarizes the contribution of AQPs in physiological and pathophysiological stages related to gastrointestinal secretion. |
format | Online Article Text |
id | pubmed-10486417 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-104864172023-09-09 Insights into the Function of Aquaporins in Gastrointestinal Fluid Absorption and Secretion in Health and Disease Calamita, Giuseppe Delporte, Christine Cells Review Aquaporins (AQPs), transmembrane proteins permeable to water, are involved in gastrointestinal secretion. The secretory products of the glands are delivered either to some organ cavities for exocrine glands or to the bloodstream for endocrine glands. The main secretory glands being part of the gastrointestinal system are salivary glands, gastric glands, duodenal Brunner’s gland, liver, bile ducts, gallbladder, intestinal goblet cells, exocrine and endocrine pancreas. Due to their expression in gastrointestinal exocrine and endocrine glands, AQPs fulfill important roles in the secretion of various fluids involved in food handling. This review summarizes the contribution of AQPs in physiological and pathophysiological stages related to gastrointestinal secretion. MDPI 2023-08-29 /pmc/articles/PMC10486417/ /pubmed/37681902 http://dx.doi.org/10.3390/cells12172170 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Calamita, Giuseppe Delporte, Christine Insights into the Function of Aquaporins in Gastrointestinal Fluid Absorption and Secretion in Health and Disease |
title | Insights into the Function of Aquaporins in Gastrointestinal Fluid Absorption and Secretion in Health and Disease |
title_full | Insights into the Function of Aquaporins in Gastrointestinal Fluid Absorption and Secretion in Health and Disease |
title_fullStr | Insights into the Function of Aquaporins in Gastrointestinal Fluid Absorption and Secretion in Health and Disease |
title_full_unstemmed | Insights into the Function of Aquaporins in Gastrointestinal Fluid Absorption and Secretion in Health and Disease |
title_short | Insights into the Function of Aquaporins in Gastrointestinal Fluid Absorption and Secretion in Health and Disease |
title_sort | insights into the function of aquaporins in gastrointestinal fluid absorption and secretion in health and disease |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10486417/ https://www.ncbi.nlm.nih.gov/pubmed/37681902 http://dx.doi.org/10.3390/cells12172170 |
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