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Mesenchymal Stem/Stromal Cells for Therapeutic Angiogenesis
Mesenchymal stem/stromal cells (MSCs) are known to possess medicinal properties to facilitate vascular regeneration. Recent advances in the understanding of the utilities of MSCs in physiological/pathological tissue repair and technologies in isolation, expansion, and enhancement strategies have led...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10486439/ https://www.ncbi.nlm.nih.gov/pubmed/37681894 http://dx.doi.org/10.3390/cells12172162 |
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author | Mohamad Yusoff, Farina Higashi, Yukihito |
author_facet | Mohamad Yusoff, Farina Higashi, Yukihito |
author_sort | Mohamad Yusoff, Farina |
collection | PubMed |
description | Mesenchymal stem/stromal cells (MSCs) are known to possess medicinal properties to facilitate vascular regeneration. Recent advances in the understanding of the utilities of MSCs in physiological/pathological tissue repair and technologies in isolation, expansion, and enhancement strategies have led to the use of MSCs for vascular disease-related treatments. Various conditions, including chronic arterial occlusive disease, diabetic ulcers, and chronic wounds, cause significant morbidity in patients. Therapeutic angiogenesis by cell therapy has led to the possibilities of treatment options in promoting angiogenesis, treating chronic wounds, and improving amputation-free survival. Current perspectives on the options for the use of MSCs for therapeutic angiogenesis in vascular research and in medicine, either as a monotherapy or in combination with conventional interventions, for treating patients with peripheral artery diseases are discussed in this review. |
format | Online Article Text |
id | pubmed-10486439 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-104864392023-09-09 Mesenchymal Stem/Stromal Cells for Therapeutic Angiogenesis Mohamad Yusoff, Farina Higashi, Yukihito Cells Review Mesenchymal stem/stromal cells (MSCs) are known to possess medicinal properties to facilitate vascular regeneration. Recent advances in the understanding of the utilities of MSCs in physiological/pathological tissue repair and technologies in isolation, expansion, and enhancement strategies have led to the use of MSCs for vascular disease-related treatments. Various conditions, including chronic arterial occlusive disease, diabetic ulcers, and chronic wounds, cause significant morbidity in patients. Therapeutic angiogenesis by cell therapy has led to the possibilities of treatment options in promoting angiogenesis, treating chronic wounds, and improving amputation-free survival. Current perspectives on the options for the use of MSCs for therapeutic angiogenesis in vascular research and in medicine, either as a monotherapy or in combination with conventional interventions, for treating patients with peripheral artery diseases are discussed in this review. MDPI 2023-08-28 /pmc/articles/PMC10486439/ /pubmed/37681894 http://dx.doi.org/10.3390/cells12172162 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Mohamad Yusoff, Farina Higashi, Yukihito Mesenchymal Stem/Stromal Cells for Therapeutic Angiogenesis |
title | Mesenchymal Stem/Stromal Cells for Therapeutic Angiogenesis |
title_full | Mesenchymal Stem/Stromal Cells for Therapeutic Angiogenesis |
title_fullStr | Mesenchymal Stem/Stromal Cells for Therapeutic Angiogenesis |
title_full_unstemmed | Mesenchymal Stem/Stromal Cells for Therapeutic Angiogenesis |
title_short | Mesenchymal Stem/Stromal Cells for Therapeutic Angiogenesis |
title_sort | mesenchymal stem/stromal cells for therapeutic angiogenesis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10486439/ https://www.ncbi.nlm.nih.gov/pubmed/37681894 http://dx.doi.org/10.3390/cells12172162 |
work_keys_str_mv | AT mohamadyusofffarina mesenchymalstemstromalcellsfortherapeuticangiogenesis AT higashiyukihito mesenchymalstemstromalcellsfortherapeuticangiogenesis |