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Mesenchymal Stem/Stromal Cells for Therapeutic Angiogenesis

Mesenchymal stem/stromal cells (MSCs) are known to possess medicinal properties to facilitate vascular regeneration. Recent advances in the understanding of the utilities of MSCs in physiological/pathological tissue repair and technologies in isolation, expansion, and enhancement strategies have led...

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Autores principales: Mohamad Yusoff, Farina, Higashi, Yukihito
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10486439/
https://www.ncbi.nlm.nih.gov/pubmed/37681894
http://dx.doi.org/10.3390/cells12172162
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author Mohamad Yusoff, Farina
Higashi, Yukihito
author_facet Mohamad Yusoff, Farina
Higashi, Yukihito
author_sort Mohamad Yusoff, Farina
collection PubMed
description Mesenchymal stem/stromal cells (MSCs) are known to possess medicinal properties to facilitate vascular regeneration. Recent advances in the understanding of the utilities of MSCs in physiological/pathological tissue repair and technologies in isolation, expansion, and enhancement strategies have led to the use of MSCs for vascular disease-related treatments. Various conditions, including chronic arterial occlusive disease, diabetic ulcers, and chronic wounds, cause significant morbidity in patients. Therapeutic angiogenesis by cell therapy has led to the possibilities of treatment options in promoting angiogenesis, treating chronic wounds, and improving amputation-free survival. Current perspectives on the options for the use of MSCs for therapeutic angiogenesis in vascular research and in medicine, either as a monotherapy or in combination with conventional interventions, for treating patients with peripheral artery diseases are discussed in this review.
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spelling pubmed-104864392023-09-09 Mesenchymal Stem/Stromal Cells for Therapeutic Angiogenesis Mohamad Yusoff, Farina Higashi, Yukihito Cells Review Mesenchymal stem/stromal cells (MSCs) are known to possess medicinal properties to facilitate vascular regeneration. Recent advances in the understanding of the utilities of MSCs in physiological/pathological tissue repair and technologies in isolation, expansion, and enhancement strategies have led to the use of MSCs for vascular disease-related treatments. Various conditions, including chronic arterial occlusive disease, diabetic ulcers, and chronic wounds, cause significant morbidity in patients. Therapeutic angiogenesis by cell therapy has led to the possibilities of treatment options in promoting angiogenesis, treating chronic wounds, and improving amputation-free survival. Current perspectives on the options for the use of MSCs for therapeutic angiogenesis in vascular research and in medicine, either as a monotherapy or in combination with conventional interventions, for treating patients with peripheral artery diseases are discussed in this review. MDPI 2023-08-28 /pmc/articles/PMC10486439/ /pubmed/37681894 http://dx.doi.org/10.3390/cells12172162 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Mohamad Yusoff, Farina
Higashi, Yukihito
Mesenchymal Stem/Stromal Cells for Therapeutic Angiogenesis
title Mesenchymal Stem/Stromal Cells for Therapeutic Angiogenesis
title_full Mesenchymal Stem/Stromal Cells for Therapeutic Angiogenesis
title_fullStr Mesenchymal Stem/Stromal Cells for Therapeutic Angiogenesis
title_full_unstemmed Mesenchymal Stem/Stromal Cells for Therapeutic Angiogenesis
title_short Mesenchymal Stem/Stromal Cells for Therapeutic Angiogenesis
title_sort mesenchymal stem/stromal cells for therapeutic angiogenesis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10486439/
https://www.ncbi.nlm.nih.gov/pubmed/37681894
http://dx.doi.org/10.3390/cells12172162
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