Locoregional Treatment in Intrahepatic Cholangiocarcinoma: Which Treatment for Which Patient?

SIMPLE SUMMARY: Due to the rarity of the entity of cholangiocarcinoma, there is a lack of randomized clinical trials which can compared modalities of treatment for unresectable intra-hepatic cholangiocarcinoma (iCC). In this review, we proposed to summarize current evidence regarding all the modalities of loco-regional treatment in iCC in order to help clinicians in their decision-making. ABSTRACT: For unresectable intrahepatic cholangiocarcinoma (iCC), different locoregional treatments (LRT) could be proposed to patients, including radiofrequency ablation (RFA) and microwave ablation (MWA), external beam radiotherapy (EBRT) or transarterial treatments, depending on patient and tumor characteristics and local expertise. These different techniques of LRT have not been compared in a randomized clinical trial; most of the relevant studies are retrospective and not comparative. The aim of this narrative review is to help clinicians in their everyday practice discuss the pros and cons of each LRT, depending on the individual characteristics of their patients.