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The Highs and Lows of FBXW7: New Insights into Substrate Affinity in Disease and Development

FBXW7 is a critical regulator of cell cycle, cell signaling, and development. A highly conserved F-box protein and component of the SKP1–Cullin–F-box (SCF) complex, FBXW7 functions as a recognition subunit within a Cullin–RING E3 ubiquitin ligase responsible for ubiquitinating substrate proteins and...

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Detalles Bibliográficos
Autor principal: de la Cova, Claire C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10486803/
https://www.ncbi.nlm.nih.gov/pubmed/37681873
http://dx.doi.org/10.3390/cells12172141