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Pathophysiology of Disseminated Intravascular Coagulation in Sepsis: A Clinically Focused Overview

Sepsis is a major global health problem that results from a dysregulated and uncontrolled host response to infection, causing organ failure. Despite effective anti-infective therapy and supportive treatments, the mortality rate of sepsis remains high. Approximately 30–80% of patients with sepsis may...

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Autores principales: Unar, Ahsanullah, Bertolino, Lorenzo, Patauner, Fabian, Gallo, Raffaella, Durante-Mangoni, Emanuele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10486945/
https://www.ncbi.nlm.nih.gov/pubmed/37681852
http://dx.doi.org/10.3390/cells12172120
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author Unar, Ahsanullah
Bertolino, Lorenzo
Patauner, Fabian
Gallo, Raffaella
Durante-Mangoni, Emanuele
author_facet Unar, Ahsanullah
Bertolino, Lorenzo
Patauner, Fabian
Gallo, Raffaella
Durante-Mangoni, Emanuele
author_sort Unar, Ahsanullah
collection PubMed
description Sepsis is a major global health problem that results from a dysregulated and uncontrolled host response to infection, causing organ failure. Despite effective anti-infective therapy and supportive treatments, the mortality rate of sepsis remains high. Approximately 30–80% of patients with sepsis may develop disseminated intravascular coagulation (DIC), which can double the mortality rate. There is currently no definitive treatment approach for sepsis, with etiologic treatment being the cornerstone of therapy for sepsis-associated DIC. Early detection, diagnosis, and treatment are critical factors that impact the prognosis of sepsis-related DIC. Over the past several decades, researchers have made continuous efforts to better understand the mechanisms of DIC in sepsis, as well as improve its quantitative diagnosis and treatment. This article aims to provide a comprehensive overview of the current understanding of sepsis-related DIC, focusing on common causes and diagnoses, with the goal of guiding healthcare providers in the care of patients with sepsis.
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spelling pubmed-104869452023-09-09 Pathophysiology of Disseminated Intravascular Coagulation in Sepsis: A Clinically Focused Overview Unar, Ahsanullah Bertolino, Lorenzo Patauner, Fabian Gallo, Raffaella Durante-Mangoni, Emanuele Cells Review Sepsis is a major global health problem that results from a dysregulated and uncontrolled host response to infection, causing organ failure. Despite effective anti-infective therapy and supportive treatments, the mortality rate of sepsis remains high. Approximately 30–80% of patients with sepsis may develop disseminated intravascular coagulation (DIC), which can double the mortality rate. There is currently no definitive treatment approach for sepsis, with etiologic treatment being the cornerstone of therapy for sepsis-associated DIC. Early detection, diagnosis, and treatment are critical factors that impact the prognosis of sepsis-related DIC. Over the past several decades, researchers have made continuous efforts to better understand the mechanisms of DIC in sepsis, as well as improve its quantitative diagnosis and treatment. This article aims to provide a comprehensive overview of the current understanding of sepsis-related DIC, focusing on common causes and diagnoses, with the goal of guiding healthcare providers in the care of patients with sepsis. MDPI 2023-08-22 /pmc/articles/PMC10486945/ /pubmed/37681852 http://dx.doi.org/10.3390/cells12172120 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Unar, Ahsanullah
Bertolino, Lorenzo
Patauner, Fabian
Gallo, Raffaella
Durante-Mangoni, Emanuele
Pathophysiology of Disseminated Intravascular Coagulation in Sepsis: A Clinically Focused Overview
title Pathophysiology of Disseminated Intravascular Coagulation in Sepsis: A Clinically Focused Overview
title_full Pathophysiology of Disseminated Intravascular Coagulation in Sepsis: A Clinically Focused Overview
title_fullStr Pathophysiology of Disseminated Intravascular Coagulation in Sepsis: A Clinically Focused Overview
title_full_unstemmed Pathophysiology of Disseminated Intravascular Coagulation in Sepsis: A Clinically Focused Overview
title_short Pathophysiology of Disseminated Intravascular Coagulation in Sepsis: A Clinically Focused Overview
title_sort pathophysiology of disseminated intravascular coagulation in sepsis: a clinically focused overview
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10486945/
https://www.ncbi.nlm.nih.gov/pubmed/37681852
http://dx.doi.org/10.3390/cells12172120
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