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Mitochondrial Properties in Skeletal Muscle Fiber

Mitochondria are the primary source of energy production and are implicated in a wide range of biological processes in most eukaryotic cells. Skeletal muscle heavily relies on mitochondria for energy supplements. In addition to being a powerhouse, mitochondria evoke many functions in skeletal muscle...

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Detalles Bibliográficos
Autores principales: Dong, Han, Tsai, Shih-Yin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10486962/
https://www.ncbi.nlm.nih.gov/pubmed/37681915
http://dx.doi.org/10.3390/cells12172183
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author Dong, Han
Tsai, Shih-Yin
author_facet Dong, Han
Tsai, Shih-Yin
author_sort Dong, Han
collection PubMed
description Mitochondria are the primary source of energy production and are implicated in a wide range of biological processes in most eukaryotic cells. Skeletal muscle heavily relies on mitochondria for energy supplements. In addition to being a powerhouse, mitochondria evoke many functions in skeletal muscle, including regulating calcium and reactive oxygen species levels. A healthy mitochondria population is necessary for the preservation of skeletal muscle homeostasis, while mitochondria dysregulation is linked to numerous myopathies. In this review, we summarize the recent studies on mitochondria function and quality control in skeletal muscle, focusing mainly on in vivo studies of rodents and human subjects. With an emphasis on the interplay between mitochondrial functions concerning the muscle fiber type-specific phenotypes, we also discuss the effect of aging and exercise on the remodeling of skeletal muscle and mitochondria properties.
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spelling pubmed-104869622023-09-09 Mitochondrial Properties in Skeletal Muscle Fiber Dong, Han Tsai, Shih-Yin Cells Review Mitochondria are the primary source of energy production and are implicated in a wide range of biological processes in most eukaryotic cells. Skeletal muscle heavily relies on mitochondria for energy supplements. In addition to being a powerhouse, mitochondria evoke many functions in skeletal muscle, including regulating calcium and reactive oxygen species levels. A healthy mitochondria population is necessary for the preservation of skeletal muscle homeostasis, while mitochondria dysregulation is linked to numerous myopathies. In this review, we summarize the recent studies on mitochondria function and quality control in skeletal muscle, focusing mainly on in vivo studies of rodents and human subjects. With an emphasis on the interplay between mitochondrial functions concerning the muscle fiber type-specific phenotypes, we also discuss the effect of aging and exercise on the remodeling of skeletal muscle and mitochondria properties. MDPI 2023-08-30 /pmc/articles/PMC10486962/ /pubmed/37681915 http://dx.doi.org/10.3390/cells12172183 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Dong, Han
Tsai, Shih-Yin
Mitochondrial Properties in Skeletal Muscle Fiber
title Mitochondrial Properties in Skeletal Muscle Fiber
title_full Mitochondrial Properties in Skeletal Muscle Fiber
title_fullStr Mitochondrial Properties in Skeletal Muscle Fiber
title_full_unstemmed Mitochondrial Properties in Skeletal Muscle Fiber
title_short Mitochondrial Properties in Skeletal Muscle Fiber
title_sort mitochondrial properties in skeletal muscle fiber
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10486962/
https://www.ncbi.nlm.nih.gov/pubmed/37681915
http://dx.doi.org/10.3390/cells12172183
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