Cargando…
Mitochondrial Properties in Skeletal Muscle Fiber
Mitochondria are the primary source of energy production and are implicated in a wide range of biological processes in most eukaryotic cells. Skeletal muscle heavily relies on mitochondria for energy supplements. In addition to being a powerhouse, mitochondria evoke many functions in skeletal muscle...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10486962/ https://www.ncbi.nlm.nih.gov/pubmed/37681915 http://dx.doi.org/10.3390/cells12172183 |
_version_ | 1785103121758814208 |
---|---|
author | Dong, Han Tsai, Shih-Yin |
author_facet | Dong, Han Tsai, Shih-Yin |
author_sort | Dong, Han |
collection | PubMed |
description | Mitochondria are the primary source of energy production and are implicated in a wide range of biological processes in most eukaryotic cells. Skeletal muscle heavily relies on mitochondria for energy supplements. In addition to being a powerhouse, mitochondria evoke many functions in skeletal muscle, including regulating calcium and reactive oxygen species levels. A healthy mitochondria population is necessary for the preservation of skeletal muscle homeostasis, while mitochondria dysregulation is linked to numerous myopathies. In this review, we summarize the recent studies on mitochondria function and quality control in skeletal muscle, focusing mainly on in vivo studies of rodents and human subjects. With an emphasis on the interplay between mitochondrial functions concerning the muscle fiber type-specific phenotypes, we also discuss the effect of aging and exercise on the remodeling of skeletal muscle and mitochondria properties. |
format | Online Article Text |
id | pubmed-10486962 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-104869622023-09-09 Mitochondrial Properties in Skeletal Muscle Fiber Dong, Han Tsai, Shih-Yin Cells Review Mitochondria are the primary source of energy production and are implicated in a wide range of biological processes in most eukaryotic cells. Skeletal muscle heavily relies on mitochondria for energy supplements. In addition to being a powerhouse, mitochondria evoke many functions in skeletal muscle, including regulating calcium and reactive oxygen species levels. A healthy mitochondria population is necessary for the preservation of skeletal muscle homeostasis, while mitochondria dysregulation is linked to numerous myopathies. In this review, we summarize the recent studies on mitochondria function and quality control in skeletal muscle, focusing mainly on in vivo studies of rodents and human subjects. With an emphasis on the interplay between mitochondrial functions concerning the muscle fiber type-specific phenotypes, we also discuss the effect of aging and exercise on the remodeling of skeletal muscle and mitochondria properties. MDPI 2023-08-30 /pmc/articles/PMC10486962/ /pubmed/37681915 http://dx.doi.org/10.3390/cells12172183 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Dong, Han Tsai, Shih-Yin Mitochondrial Properties in Skeletal Muscle Fiber |
title | Mitochondrial Properties in Skeletal Muscle Fiber |
title_full | Mitochondrial Properties in Skeletal Muscle Fiber |
title_fullStr | Mitochondrial Properties in Skeletal Muscle Fiber |
title_full_unstemmed | Mitochondrial Properties in Skeletal Muscle Fiber |
title_short | Mitochondrial Properties in Skeletal Muscle Fiber |
title_sort | mitochondrial properties in skeletal muscle fiber |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10486962/ https://www.ncbi.nlm.nih.gov/pubmed/37681915 http://dx.doi.org/10.3390/cells12172183 |
work_keys_str_mv | AT donghan mitochondrialpropertiesinskeletalmusclefiber AT tsaishihyin mitochondrialpropertiesinskeletalmusclefiber |