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Concussion: Beyond the Cascade

Sport concussion affects millions of athletes each year at all levels of sport. Increasing evidence demonstrates clinical and physiological recovery are becoming more divergent definitions, as evidenced by several studies examining blood-based biomarkers of inflammation and imaging studies of the ce...

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Autores principales: Neumann, Kiel D., Broshek, Donna K., Newman, Benjamin T., Druzgal, T. Jason, Kundu, Bijoy K., Resch, Jacob E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10487087/
https://www.ncbi.nlm.nih.gov/pubmed/37681861
http://dx.doi.org/10.3390/cells12172128
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author Neumann, Kiel D.
Broshek, Donna K.
Newman, Benjamin T.
Druzgal, T. Jason
Kundu, Bijoy K.
Resch, Jacob E.
author_facet Neumann, Kiel D.
Broshek, Donna K.
Newman, Benjamin T.
Druzgal, T. Jason
Kundu, Bijoy K.
Resch, Jacob E.
author_sort Neumann, Kiel D.
collection PubMed
description Sport concussion affects millions of athletes each year at all levels of sport. Increasing evidence demonstrates clinical and physiological recovery are becoming more divergent definitions, as evidenced by several studies examining blood-based biomarkers of inflammation and imaging studies of the central nervous system (CNS). Recent studies have shown elevated microglial activation in the CNS in active and retired American football players, as well as in active collegiate athletes who were diagnosed with a concussion and returned to sport. These data are supportive of discordance in clinical symptomology and the inflammatory response in the CNS upon symptom resolution. In this review, we will summarize recent advances in the understanding of the inflammatory response associated with sport concussion and broader mild traumatic brain injury, as well as provide an outlook for important research questions to better align clinical and physiological recovery.
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spelling pubmed-104870872023-09-09 Concussion: Beyond the Cascade Neumann, Kiel D. Broshek, Donna K. Newman, Benjamin T. Druzgal, T. Jason Kundu, Bijoy K. Resch, Jacob E. Cells Review Sport concussion affects millions of athletes each year at all levels of sport. Increasing evidence demonstrates clinical and physiological recovery are becoming more divergent definitions, as evidenced by several studies examining blood-based biomarkers of inflammation and imaging studies of the central nervous system (CNS). Recent studies have shown elevated microglial activation in the CNS in active and retired American football players, as well as in active collegiate athletes who were diagnosed with a concussion and returned to sport. These data are supportive of discordance in clinical symptomology and the inflammatory response in the CNS upon symptom resolution. In this review, we will summarize recent advances in the understanding of the inflammatory response associated with sport concussion and broader mild traumatic brain injury, as well as provide an outlook for important research questions to better align clinical and physiological recovery. MDPI 2023-08-22 /pmc/articles/PMC10487087/ /pubmed/37681861 http://dx.doi.org/10.3390/cells12172128 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Neumann, Kiel D.
Broshek, Donna K.
Newman, Benjamin T.
Druzgal, T. Jason
Kundu, Bijoy K.
Resch, Jacob E.
Concussion: Beyond the Cascade
title Concussion: Beyond the Cascade
title_full Concussion: Beyond the Cascade
title_fullStr Concussion: Beyond the Cascade
title_full_unstemmed Concussion: Beyond the Cascade
title_short Concussion: Beyond the Cascade
title_sort concussion: beyond the cascade
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10487087/
https://www.ncbi.nlm.nih.gov/pubmed/37681861
http://dx.doi.org/10.3390/cells12172128
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