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Failure of a Multi-Centric Clinical Trial Investigating Neoadjuvant Radio-Chemotherapy in Resectable Pancreatic Carcinoma (NEOPA-NCT01900327)—Which Lessons Are Learnt?

SIMPLE SUMMARY: The NEOPA trial was a large clinical trial in Germany, funded by the German government. It aimed to investigate if a treatment before the surgical removal of pancreatic head cancer, consisting of a combined local radiation and chemotherapy, might improve the survival of the patients....

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Autores principales: Tachezy, Michael, Gebauer, Florian, Yekebas, Emre, Izbicki, Jakob Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10487154/
https://www.ncbi.nlm.nih.gov/pubmed/37686537
http://dx.doi.org/10.3390/cancers15174262
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author Tachezy, Michael
Gebauer, Florian
Yekebas, Emre
Izbicki, Jakob Robert
author_facet Tachezy, Michael
Gebauer, Florian
Yekebas, Emre
Izbicki, Jakob Robert
author_sort Tachezy, Michael
collection PubMed
description SIMPLE SUMMARY: The NEOPA trial was a large clinical trial in Germany, funded by the German government. It aimed to investigate if a treatment before the surgical removal of pancreatic head cancer, consisting of a combined local radiation and chemotherapy, might improve the survival of the patients. The trial had to be discontinued due to recruitment failure. In this article, the reasons for this are investigated and discussed, intending to draw lessens for future research initiatives and to address deficiencies in the surgical study culture. ABSTRACT: Background: A significant number of clinical trials must be prematurely discontinued due to recruitment failure, and only a small fraction publish results and a failure analysis. Based on our experience on conducting the NEOPA trial on neoadjuvant radiochemotherapy for resectable and borderline resectable pancreatic carcinoma (NCT01900327—funded by the German Federal Ministry of Education and Research—BMBF), we performed an analysis of potential reasons for recruitment failure and general problems in conducting clinical trials in Germany. Methods: Systematic analysis of environmental factors, trial history, conducting and funding in the background of the published literature. Results: The recruitment failure was based on various study-specific conceptional and local environmental aspects and in peculiarities of the German surgical study culture. General reservations against a neo-adjuvant study concept combined with game changing scientific progresses during the long-lasting planning and funding phase have led to a reduced interest in the trial design and recruitment. Conclusions: Trial planning and conducting should be focused, professionalized and financed on a national basis. Individual interests must be subordinated to reach the goal to perform more relevant and successful clinical trials in Germany. Bureaucratic processes must be further fastened between a trial idea and the start of a study.
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spelling pubmed-104871542023-09-09 Failure of a Multi-Centric Clinical Trial Investigating Neoadjuvant Radio-Chemotherapy in Resectable Pancreatic Carcinoma (NEOPA-NCT01900327)—Which Lessons Are Learnt? Tachezy, Michael Gebauer, Florian Yekebas, Emre Izbicki, Jakob Robert Cancers (Basel) Article SIMPLE SUMMARY: The NEOPA trial was a large clinical trial in Germany, funded by the German government. It aimed to investigate if a treatment before the surgical removal of pancreatic head cancer, consisting of a combined local radiation and chemotherapy, might improve the survival of the patients. The trial had to be discontinued due to recruitment failure. In this article, the reasons for this are investigated and discussed, intending to draw lessens for future research initiatives and to address deficiencies in the surgical study culture. ABSTRACT: Background: A significant number of clinical trials must be prematurely discontinued due to recruitment failure, and only a small fraction publish results and a failure analysis. Based on our experience on conducting the NEOPA trial on neoadjuvant radiochemotherapy for resectable and borderline resectable pancreatic carcinoma (NCT01900327—funded by the German Federal Ministry of Education and Research—BMBF), we performed an analysis of potential reasons for recruitment failure and general problems in conducting clinical trials in Germany. Methods: Systematic analysis of environmental factors, trial history, conducting and funding in the background of the published literature. Results: The recruitment failure was based on various study-specific conceptional and local environmental aspects and in peculiarities of the German surgical study culture. General reservations against a neo-adjuvant study concept combined with game changing scientific progresses during the long-lasting planning and funding phase have led to a reduced interest in the trial design and recruitment. Conclusions: Trial planning and conducting should be focused, professionalized and financed on a national basis. Individual interests must be subordinated to reach the goal to perform more relevant and successful clinical trials in Germany. Bureaucratic processes must be further fastened between a trial idea and the start of a study. MDPI 2023-08-25 /pmc/articles/PMC10487154/ /pubmed/37686537 http://dx.doi.org/10.3390/cancers15174262 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Tachezy, Michael
Gebauer, Florian
Yekebas, Emre
Izbicki, Jakob Robert
Failure of a Multi-Centric Clinical Trial Investigating Neoadjuvant Radio-Chemotherapy in Resectable Pancreatic Carcinoma (NEOPA-NCT01900327)—Which Lessons Are Learnt?
title Failure of a Multi-Centric Clinical Trial Investigating Neoadjuvant Radio-Chemotherapy in Resectable Pancreatic Carcinoma (NEOPA-NCT01900327)—Which Lessons Are Learnt?
title_full Failure of a Multi-Centric Clinical Trial Investigating Neoadjuvant Radio-Chemotherapy in Resectable Pancreatic Carcinoma (NEOPA-NCT01900327)—Which Lessons Are Learnt?
title_fullStr Failure of a Multi-Centric Clinical Trial Investigating Neoadjuvant Radio-Chemotherapy in Resectable Pancreatic Carcinoma (NEOPA-NCT01900327)—Which Lessons Are Learnt?
title_full_unstemmed Failure of a Multi-Centric Clinical Trial Investigating Neoadjuvant Radio-Chemotherapy in Resectable Pancreatic Carcinoma (NEOPA-NCT01900327)—Which Lessons Are Learnt?
title_short Failure of a Multi-Centric Clinical Trial Investigating Neoadjuvant Radio-Chemotherapy in Resectable Pancreatic Carcinoma (NEOPA-NCT01900327)—Which Lessons Are Learnt?
title_sort failure of a multi-centric clinical trial investigating neoadjuvant radio-chemotherapy in resectable pancreatic carcinoma (neopa-nct01900327)—which lessons are learnt?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10487154/
https://www.ncbi.nlm.nih.gov/pubmed/37686537
http://dx.doi.org/10.3390/cancers15174262
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