Cargando…

SMAD Proteins in TGF-β Signalling Pathway in Cancer: Regulatory Mechanisms and Clinical Applications

Suppressor of mother against decapentaplegic (SMAD) family proteins are central to one of the most versatile cytokine signalling pathways in metazoan biology, the transforming growth factor-β (TGF-β) pathway. The TGF-β pathway is widely known for its dual role in cancer progression as both an inhibi...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Qi, Xiong, Fei, Wu, Guanhua, Wang, Da, Liu, Wenzheng, Chen, Junsheng, Qi, Yongqiang, Wang, Bing, Chen, Yongjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10487229/
https://www.ncbi.nlm.nih.gov/pubmed/37685308
http://dx.doi.org/10.3390/diagnostics13172769
_version_ 1785103190336733184
author Wang, Qi
Xiong, Fei
Wu, Guanhua
Wang, Da
Liu, Wenzheng
Chen, Junsheng
Qi, Yongqiang
Wang, Bing
Chen, Yongjun
author_facet Wang, Qi
Xiong, Fei
Wu, Guanhua
Wang, Da
Liu, Wenzheng
Chen, Junsheng
Qi, Yongqiang
Wang, Bing
Chen, Yongjun
author_sort Wang, Qi
collection PubMed
description Suppressor of mother against decapentaplegic (SMAD) family proteins are central to one of the most versatile cytokine signalling pathways in metazoan biology, the transforming growth factor-β (TGF-β) pathway. The TGF-β pathway is widely known for its dual role in cancer progression as both an inhibitor of tumour cell growth and an inducer of tumour metastasis. This is mainly mediated through SMAD proteins and their cofactors or regulators. SMAD proteins act as transcription factors, regulating the transcription of a wide range of genes, and their rich post-translational modifications are influenced by a variety of regulators and cofactors. The complex role, mechanisms, and important functions of SMAD proteins in tumours are the hot topics in current oncology research. In this paper, we summarize the recent progress on the effects and mechanisms of SMAD proteins on tumour development, diagnosis, treatment and prognosis, and provide clues for subsequent research on SMAD proteins in tumours.
format Online
Article
Text
id pubmed-10487229
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-104872292023-09-09 SMAD Proteins in TGF-β Signalling Pathway in Cancer: Regulatory Mechanisms and Clinical Applications Wang, Qi Xiong, Fei Wu, Guanhua Wang, Da Liu, Wenzheng Chen, Junsheng Qi, Yongqiang Wang, Bing Chen, Yongjun Diagnostics (Basel) Review Suppressor of mother against decapentaplegic (SMAD) family proteins are central to one of the most versatile cytokine signalling pathways in metazoan biology, the transforming growth factor-β (TGF-β) pathway. The TGF-β pathway is widely known for its dual role in cancer progression as both an inhibitor of tumour cell growth and an inducer of tumour metastasis. This is mainly mediated through SMAD proteins and their cofactors or regulators. SMAD proteins act as transcription factors, regulating the transcription of a wide range of genes, and their rich post-translational modifications are influenced by a variety of regulators and cofactors. The complex role, mechanisms, and important functions of SMAD proteins in tumours are the hot topics in current oncology research. In this paper, we summarize the recent progress on the effects and mechanisms of SMAD proteins on tumour development, diagnosis, treatment and prognosis, and provide clues for subsequent research on SMAD proteins in tumours. MDPI 2023-08-26 /pmc/articles/PMC10487229/ /pubmed/37685308 http://dx.doi.org/10.3390/diagnostics13172769 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Wang, Qi
Xiong, Fei
Wu, Guanhua
Wang, Da
Liu, Wenzheng
Chen, Junsheng
Qi, Yongqiang
Wang, Bing
Chen, Yongjun
SMAD Proteins in TGF-β Signalling Pathway in Cancer: Regulatory Mechanisms and Clinical Applications
title SMAD Proteins in TGF-β Signalling Pathway in Cancer: Regulatory Mechanisms and Clinical Applications
title_full SMAD Proteins in TGF-β Signalling Pathway in Cancer: Regulatory Mechanisms and Clinical Applications
title_fullStr SMAD Proteins in TGF-β Signalling Pathway in Cancer: Regulatory Mechanisms and Clinical Applications
title_full_unstemmed SMAD Proteins in TGF-β Signalling Pathway in Cancer: Regulatory Mechanisms and Clinical Applications
title_short SMAD Proteins in TGF-β Signalling Pathway in Cancer: Regulatory Mechanisms and Clinical Applications
title_sort smad proteins in tgf-β signalling pathway in cancer: regulatory mechanisms and clinical applications
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10487229/
https://www.ncbi.nlm.nih.gov/pubmed/37685308
http://dx.doi.org/10.3390/diagnostics13172769
work_keys_str_mv AT wangqi smadproteinsintgfbsignallingpathwayincancerregulatorymechanismsandclinicalapplications
AT xiongfei smadproteinsintgfbsignallingpathwayincancerregulatorymechanismsandclinicalapplications
AT wuguanhua smadproteinsintgfbsignallingpathwayincancerregulatorymechanismsandclinicalapplications
AT wangda smadproteinsintgfbsignallingpathwayincancerregulatorymechanismsandclinicalapplications
AT liuwenzheng smadproteinsintgfbsignallingpathwayincancerregulatorymechanismsandclinicalapplications
AT chenjunsheng smadproteinsintgfbsignallingpathwayincancerregulatorymechanismsandclinicalapplications
AT qiyongqiang smadproteinsintgfbsignallingpathwayincancerregulatorymechanismsandclinicalapplications
AT wangbing smadproteinsintgfbsignallingpathwayincancerregulatorymechanismsandclinicalapplications
AT chenyongjun smadproteinsintgfbsignallingpathwayincancerregulatorymechanismsandclinicalapplications