Dysregulation and implications of N6-methyladenosine modification in renal cell carcinoma

Increasing evidence indicates that N(6)-methyladenosine (m(6)A) methylation modification serves important functions in biological metabolism. Dysregulation of m(6)A regulators is related to the progression of different malignancies, including renal cell carcinoma (RCC). Recent studies have reported...

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Autores principales: Wu, Yaohai, Zhang, Shiqiang, Chen, Chujie, Pang, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Special Topic: Advances in Renal Cell Carcinoma Therapy: Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10487297/
https://www.ncbi.nlm.nih.gov/pubmed/37692138
http://dx.doi.org/10.1097/CU9.0000000000000135
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author Wu, Yaohai
Zhang, Shiqiang
Chen, Chujie
Pang, Jun
author_facet Wu, Yaohai
Zhang, Shiqiang
Chen, Chujie
Pang, Jun
author_sort Wu, Yaohai
collection PubMed
description Increasing evidence indicates that N(6)-methyladenosine (m(6)A) methylation modification serves important functions in biological metabolism. Dysregulation of m(6)A regulators is related to the progression of different malignancies, including renal cell carcinoma (RCC). Recent studies have reported preliminary findings on the influence of m(6)A regulator dysregulation on RCC tumorigenesis and development. However, no comprehensive review that integrates and analyzes the roles of m(6)A modification in RCC has been published to date. In this review, we focus on the dysregulation of m(6)A regulators as it relates to RCC tumorigenesis and development, as well as possible applications of m(6)A modification in RCC diagnosis and therapeutics.
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spelling pubmed-104872972023-09-09 Dysregulation and implications of N6-methyladenosine modification in renal cell carcinoma Wu, Yaohai Zhang, Shiqiang Chen, Chujie Pang, Jun Curr Urol Special Topic: Advances in Renal Cell Carcinoma Therapy: Review Increasing evidence indicates that N(6)-methyladenosine (m(6)A) methylation modification serves important functions in biological metabolism. Dysregulation of m(6)A regulators is related to the progression of different malignancies, including renal cell carcinoma (RCC). Recent studies have reported preliminary findings on the influence of m(6)A regulator dysregulation on RCC tumorigenesis and development. However, no comprehensive review that integrates and analyzes the roles of m(6)A modification in RCC has been published to date. In this review, we focus on the dysregulation of m(6)A regulators as it relates to RCC tumorigenesis and development, as well as possible applications of m(6)A modification in RCC diagnosis and therapeutics. Lippincott Williams & Wilkins 2023-03 2022-08-22 /pmc/articles/PMC10487297/ /pubmed/37692138 http://dx.doi.org/10.1097/CU9.0000000000000135 Text en Copyright © 2022 The Authors. Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle Special Topic: Advances in Renal Cell Carcinoma Therapy: Review
Wu, Yaohai
Zhang, Shiqiang
Chen, Chujie
Pang, Jun
Dysregulation and implications of N6-methyladenosine modification in renal cell carcinoma
title Dysregulation and implications of N6-methyladenosine modification in renal cell carcinoma
title_full Dysregulation and implications of N6-methyladenosine modification in renal cell carcinoma
title_fullStr Dysregulation and implications of N6-methyladenosine modification in renal cell carcinoma
title_full_unstemmed Dysregulation and implications of N6-methyladenosine modification in renal cell carcinoma
title_short Dysregulation and implications of N6-methyladenosine modification in renal cell carcinoma
title_sort dysregulation and implications of n6-methyladenosine modification in renal cell carcinoma
topic Special Topic: Advances in Renal Cell Carcinoma Therapy: Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10487297/
https://www.ncbi.nlm.nih.gov/pubmed/37692138
http://dx.doi.org/10.1097/CU9.0000000000000135
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