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Basic research and clinical exploration of cold atmospheric plasma for skin wounds

Skin wounds, such as burns, diabetic foot ulcers, pressure sores, and wounds formed after laser or surgical treatment, comprise a very high proportion of dermatological disorders. Wounds are treated in a variety of ways; however, some wounds are greatly resistant, resulting in delayed healing and an...

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Autores principales: Li, Miaomiao, Gao, Jing, Wang, Liyun, Liu, Jia, Fu, Chuyu, Yang, Xingyu, Zhang, Shengquan, Li, Xinwei, Luo, Shengyong, Yang, Chunjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10487309/
https://www.ncbi.nlm.nih.gov/pubmed/37693064
http://dx.doi.org/10.1002/btm2.10550
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author Li, Miaomiao
Gao, Jing
Wang, Liyun
Liu, Jia
Fu, Chuyu
Yang, Xingyu
Zhang, Shengquan
Li, Xinwei
Luo, Shengyong
Yang, Chunjun
author_facet Li, Miaomiao
Gao, Jing
Wang, Liyun
Liu, Jia
Fu, Chuyu
Yang, Xingyu
Zhang, Shengquan
Li, Xinwei
Luo, Shengyong
Yang, Chunjun
author_sort Li, Miaomiao
collection PubMed
description Skin wounds, such as burns, diabetic foot ulcers, pressure sores, and wounds formed after laser or surgical treatment, comprise a very high proportion of dermatological disorders. Wounds are treated in a variety of ways; however, some wounds are greatly resistant, resulting in delayed healing and an urgent need to introduce new alternatives. Our previous studies have shown that cold atmospheric plasma (CAP) has antibacterial activity and promotes cell proliferation, differentiation, and migration in vitro. To further advance the role of CAP in wound healing, we evaluated the safety and efficacy of CAP in vitro by irradiation of common refractory bacteria on the skin, irradiation of normal skin of rats and observing reactions, treatment of scald wounds in rats, and treating clinically common acute wounds. Our findings revealed that CAP can eliminate refractory skin bacteria in vitro; CAP positively affected wound healing in a rat scalding wound model; and direct CAP irradiation of low intensity and short duration did not lead to skin erythema or edema. CAP promises to be a new, economical, and safe means of wound treatment.
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spelling pubmed-104873092023-09-09 Basic research and clinical exploration of cold atmospheric plasma for skin wounds Li, Miaomiao Gao, Jing Wang, Liyun Liu, Jia Fu, Chuyu Yang, Xingyu Zhang, Shengquan Li, Xinwei Luo, Shengyong Yang, Chunjun Bioeng Transl Med Regular Issue Articles Skin wounds, such as burns, diabetic foot ulcers, pressure sores, and wounds formed after laser or surgical treatment, comprise a very high proportion of dermatological disorders. Wounds are treated in a variety of ways; however, some wounds are greatly resistant, resulting in delayed healing and an urgent need to introduce new alternatives. Our previous studies have shown that cold atmospheric plasma (CAP) has antibacterial activity and promotes cell proliferation, differentiation, and migration in vitro. To further advance the role of CAP in wound healing, we evaluated the safety and efficacy of CAP in vitro by irradiation of common refractory bacteria on the skin, irradiation of normal skin of rats and observing reactions, treatment of scald wounds in rats, and treating clinically common acute wounds. Our findings revealed that CAP can eliminate refractory skin bacteria in vitro; CAP positively affected wound healing in a rat scalding wound model; and direct CAP irradiation of low intensity and short duration did not lead to skin erythema or edema. CAP promises to be a new, economical, and safe means of wound treatment. John Wiley & Sons, Inc. 2023-05-26 /pmc/articles/PMC10487309/ /pubmed/37693064 http://dx.doi.org/10.1002/btm2.10550 Text en © 2023 The Authors. Bioengineering & Translational Medicine published by Wiley Periodicals LLC on behalf of American Institute of Chemical Engineers. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Regular Issue Articles
Li, Miaomiao
Gao, Jing
Wang, Liyun
Liu, Jia
Fu, Chuyu
Yang, Xingyu
Zhang, Shengquan
Li, Xinwei
Luo, Shengyong
Yang, Chunjun
Basic research and clinical exploration of cold atmospheric plasma for skin wounds
title Basic research and clinical exploration of cold atmospheric plasma for skin wounds
title_full Basic research and clinical exploration of cold atmospheric plasma for skin wounds
title_fullStr Basic research and clinical exploration of cold atmospheric plasma for skin wounds
title_full_unstemmed Basic research and clinical exploration of cold atmospheric plasma for skin wounds
title_short Basic research and clinical exploration of cold atmospheric plasma for skin wounds
title_sort basic research and clinical exploration of cold atmospheric plasma for skin wounds
topic Regular Issue Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10487309/
https://www.ncbi.nlm.nih.gov/pubmed/37693064
http://dx.doi.org/10.1002/btm2.10550
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