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Basic research and clinical exploration of cold atmospheric plasma for skin wounds
Skin wounds, such as burns, diabetic foot ulcers, pressure sores, and wounds formed after laser or surgical treatment, comprise a very high proportion of dermatological disorders. Wounds are treated in a variety of ways; however, some wounds are greatly resistant, resulting in delayed healing and an...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons, Inc.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10487309/ https://www.ncbi.nlm.nih.gov/pubmed/37693064 http://dx.doi.org/10.1002/btm2.10550 |
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author | Li, Miaomiao Gao, Jing Wang, Liyun Liu, Jia Fu, Chuyu Yang, Xingyu Zhang, Shengquan Li, Xinwei Luo, Shengyong Yang, Chunjun |
author_facet | Li, Miaomiao Gao, Jing Wang, Liyun Liu, Jia Fu, Chuyu Yang, Xingyu Zhang, Shengquan Li, Xinwei Luo, Shengyong Yang, Chunjun |
author_sort | Li, Miaomiao |
collection | PubMed |
description | Skin wounds, such as burns, diabetic foot ulcers, pressure sores, and wounds formed after laser or surgical treatment, comprise a very high proportion of dermatological disorders. Wounds are treated in a variety of ways; however, some wounds are greatly resistant, resulting in delayed healing and an urgent need to introduce new alternatives. Our previous studies have shown that cold atmospheric plasma (CAP) has antibacterial activity and promotes cell proliferation, differentiation, and migration in vitro. To further advance the role of CAP in wound healing, we evaluated the safety and efficacy of CAP in vitro by irradiation of common refractory bacteria on the skin, irradiation of normal skin of rats and observing reactions, treatment of scald wounds in rats, and treating clinically common acute wounds. Our findings revealed that CAP can eliminate refractory skin bacteria in vitro; CAP positively affected wound healing in a rat scalding wound model; and direct CAP irradiation of low intensity and short duration did not lead to skin erythema or edema. CAP promises to be a new, economical, and safe means of wound treatment. |
format | Online Article Text |
id | pubmed-10487309 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | John Wiley & Sons, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-104873092023-09-09 Basic research and clinical exploration of cold atmospheric plasma for skin wounds Li, Miaomiao Gao, Jing Wang, Liyun Liu, Jia Fu, Chuyu Yang, Xingyu Zhang, Shengquan Li, Xinwei Luo, Shengyong Yang, Chunjun Bioeng Transl Med Regular Issue Articles Skin wounds, such as burns, diabetic foot ulcers, pressure sores, and wounds formed after laser or surgical treatment, comprise a very high proportion of dermatological disorders. Wounds are treated in a variety of ways; however, some wounds are greatly resistant, resulting in delayed healing and an urgent need to introduce new alternatives. Our previous studies have shown that cold atmospheric plasma (CAP) has antibacterial activity and promotes cell proliferation, differentiation, and migration in vitro. To further advance the role of CAP in wound healing, we evaluated the safety and efficacy of CAP in vitro by irradiation of common refractory bacteria on the skin, irradiation of normal skin of rats and observing reactions, treatment of scald wounds in rats, and treating clinically common acute wounds. Our findings revealed that CAP can eliminate refractory skin bacteria in vitro; CAP positively affected wound healing in a rat scalding wound model; and direct CAP irradiation of low intensity and short duration did not lead to skin erythema or edema. CAP promises to be a new, economical, and safe means of wound treatment. John Wiley & Sons, Inc. 2023-05-26 /pmc/articles/PMC10487309/ /pubmed/37693064 http://dx.doi.org/10.1002/btm2.10550 Text en © 2023 The Authors. Bioengineering & Translational Medicine published by Wiley Periodicals LLC on behalf of American Institute of Chemical Engineers. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Regular Issue Articles Li, Miaomiao Gao, Jing Wang, Liyun Liu, Jia Fu, Chuyu Yang, Xingyu Zhang, Shengquan Li, Xinwei Luo, Shengyong Yang, Chunjun Basic research and clinical exploration of cold atmospheric plasma for skin wounds |
title | Basic research and clinical exploration of cold atmospheric plasma for skin wounds |
title_full | Basic research and clinical exploration of cold atmospheric plasma for skin wounds |
title_fullStr | Basic research and clinical exploration of cold atmospheric plasma for skin wounds |
title_full_unstemmed | Basic research and clinical exploration of cold atmospheric plasma for skin wounds |
title_short | Basic research and clinical exploration of cold atmospheric plasma for skin wounds |
title_sort | basic research and clinical exploration of cold atmospheric plasma for skin wounds |
topic | Regular Issue Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10487309/ https://www.ncbi.nlm.nih.gov/pubmed/37693064 http://dx.doi.org/10.1002/btm2.10550 |
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