A high‐throughput microfluidic mechanoporation platform to enable intracellular delivery of cyclic peptides in cell‐based assays

Cyclic peptides are poised to target historically difficult to drug intracellular protein–protein interactions, however, their general cell impermeability poses a challenge for characterizing function. Recent advances in microfluidics have enabled permeabilization of the cytoplasmic membrane by phys...

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Detalles Bibliográficos
Autores principales: Kasper, Stephen H., Otten, Stephanie, Squadroni, Brian, Orr‐Terry, Cionna, Kuang, Yi, Mussallem, Lily, Ge, Lan, Yan, Lin, Kannan, Srinivasaraghavan, Verma, Chandra S., Brown, Christopher J., Johannes, Charles W., Lane, David P., Chandramohan, Arun, Partridge, Anthony W., Roberts, Lee R., Josien, Hubert, Therien, Alex G., Hett, Erik C., Howell, Bonnie J., Peier, Andrea, Ai, Xi, Cassaday, Jason
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2023
Materias:
Regular Issue Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10487316/
https://www.ncbi.nlm.nih.gov/pubmed/37693049
http://dx.doi.org/10.1002/btm2.10542

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