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Optimization of a Nucleophilic Two-Step Radiosynthesis of 6-O-(2-[(18)F]fluoroethyl)-6-O-desmethyl-diprenorphine ([(18)F]FE-DPN) for PET Imaging of Brain Opioid Receptors

We have established a method for nucleophilic one-pot, two-step radiosynthesis of the popular opioid receptor radioligand 6-O-(2-[(18)F]fluoroethyl)-6-O-desmethyl-diprenorphine ([(18)F]FE-DPN) from the novel precursor 6-O-(2-tosyloxyethyl)-6-O-desmethyl- 3-O-trityl-diprenorphine (TE-TDDPN), which we...

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Detalles Bibliográficos
Autores principales:	Németh, Enikő, Gyuricza, Barbara, Forgács, Viktória, Cumming, Paul, Henriksen, Gjermund, Marton, János, Bauer, Beate, Mikecz, Pál, Fekete, Anikó
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10487412/ https://www.ncbi.nlm.nih.gov/pubmed/37685958 http://dx.doi.org/10.3390/ijms241713152

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