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Suicidal Ideation and Electroconvulsive Therapy: Outcomes in Adolescents With Major Depressive Disorder

OBJECTIVE: Few studies on electroconvulsive therapy (ECT) investigate efficacy and safety on depressive adolescents with strong suicidal ideation. Our study examined adolescents (aged 13–18 years) with major depressive disorder to explore ECT effectiveness in improving suicidal ideation and depressi...

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Autores principales: Cai, Haipeng, Du, Ruonan, Song, Jiaqi, Wang, Zhiren, Wang, Xin, Yu, Yongjun, Wang, Yanan, Shang, Lan, Zhang, Jianxin, Yang, Kebing, Li, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10487452/
https://www.ncbi.nlm.nih.gov/pubmed/36800536
http://dx.doi.org/10.1097/YCT.0000000000000906
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author Cai, Haipeng
Du, Ruonan
Song, Jiaqi
Wang, Zhiren
Wang, Xin
Yu, Yongjun
Wang, Yanan
Shang, Lan
Zhang, Jianxin
Yang, Kebing
Li, Wei
author_facet Cai, Haipeng
Du, Ruonan
Song, Jiaqi
Wang, Zhiren
Wang, Xin
Yu, Yongjun
Wang, Yanan
Shang, Lan
Zhang, Jianxin
Yang, Kebing
Li, Wei
author_sort Cai, Haipeng
collection PubMed
description OBJECTIVE: Few studies on electroconvulsive therapy (ECT) investigate efficacy and safety on depressive adolescents with strong suicidal ideation. Our study examined adolescents (aged 13–18 years) with major depressive disorder to explore ECT effectiveness in improving suicidal ideation and depressive symptoms, as well as its impact on cognitive function. METHODS: This nonrandomized controlled trial enrolled 183 adolescent patients suffering from major depressive disorder. The ECT group (n = 81) was treated with antidepressants and 8 rounds of ECT for 2 weeks. The control group comprised 79 patients treated with antidepressants only. Depressive symptoms, suicidal ideation, and cognitive functions were assessed at baseline (pre-ECT) and at 2 and 6 weeks post-ECT. RESULTS: The ECT group showed significant improvements over control in suicidal ideation from the end of treatment to 6 weeks after (P < 0.001). Depressive symptoms also improved (P < 0.001). Patients treated with ECT demonstrated poorer performance in delayed memory, attention, and language, but these impairments were transient. Thus, ECT was generally safe in adolescent patients with major depressive disorder. CONCLUSIONS: Our findings verified ECT as effective and safe for improving suicidal ideation and depressive symptoms of adolescent patients with major depressive disorder. In addition, partially impaired cognitive function recovered gradually after ECT.
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spelling pubmed-104874522023-09-09 Suicidal Ideation and Electroconvulsive Therapy: Outcomes in Adolescents With Major Depressive Disorder Cai, Haipeng Du, Ruonan Song, Jiaqi Wang, Zhiren Wang, Xin Yu, Yongjun Wang, Yanan Shang, Lan Zhang, Jianxin Yang, Kebing Li, Wei J ECT Original Studies OBJECTIVE: Few studies on electroconvulsive therapy (ECT) investigate efficacy and safety on depressive adolescents with strong suicidal ideation. Our study examined adolescents (aged 13–18 years) with major depressive disorder to explore ECT effectiveness in improving suicidal ideation and depressive symptoms, as well as its impact on cognitive function. METHODS: This nonrandomized controlled trial enrolled 183 adolescent patients suffering from major depressive disorder. The ECT group (n = 81) was treated with antidepressants and 8 rounds of ECT for 2 weeks. The control group comprised 79 patients treated with antidepressants only. Depressive symptoms, suicidal ideation, and cognitive functions were assessed at baseline (pre-ECT) and at 2 and 6 weeks post-ECT. RESULTS: The ECT group showed significant improvements over control in suicidal ideation from the end of treatment to 6 weeks after (P < 0.001). Depressive symptoms also improved (P < 0.001). Patients treated with ECT demonstrated poorer performance in delayed memory, attention, and language, but these impairments were transient. Thus, ECT was generally safe in adolescent patients with major depressive disorder. CONCLUSIONS: Our findings verified ECT as effective and safe for improving suicidal ideation and depressive symptoms of adolescent patients with major depressive disorder. In addition, partially impaired cognitive function recovered gradually after ECT. Lippincott Williams & Wilkins 2023-09 2023-01-30 /pmc/articles/PMC10487452/ /pubmed/36800536 http://dx.doi.org/10.1097/YCT.0000000000000906 Text en Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle Original Studies
Cai, Haipeng
Du, Ruonan
Song, Jiaqi
Wang, Zhiren
Wang, Xin
Yu, Yongjun
Wang, Yanan
Shang, Lan
Zhang, Jianxin
Yang, Kebing
Li, Wei
Suicidal Ideation and Electroconvulsive Therapy: Outcomes in Adolescents With Major Depressive Disorder
title Suicidal Ideation and Electroconvulsive Therapy: Outcomes in Adolescents With Major Depressive Disorder
title_full Suicidal Ideation and Electroconvulsive Therapy: Outcomes in Adolescents With Major Depressive Disorder
title_fullStr Suicidal Ideation and Electroconvulsive Therapy: Outcomes in Adolescents With Major Depressive Disorder
title_full_unstemmed Suicidal Ideation and Electroconvulsive Therapy: Outcomes in Adolescents With Major Depressive Disorder
title_short Suicidal Ideation and Electroconvulsive Therapy: Outcomes in Adolescents With Major Depressive Disorder
title_sort suicidal ideation and electroconvulsive therapy: outcomes in adolescents with major depressive disorder
topic Original Studies
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10487452/
https://www.ncbi.nlm.nih.gov/pubmed/36800536
http://dx.doi.org/10.1097/YCT.0000000000000906
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