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Ganglionated Plexus Ablation Procedures to Treat Vasovagal Syncope
Vasovagal syncope (VVS) refers to a heterogeneous group of conditions whereby the cardiovascular reflexes normally controlling the circulation are interrupted irregularly in response to a trigger, resulting in vasodilation, bradycardia, or both. VVS affects one-third of the population at least once...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10487499/ https://www.ncbi.nlm.nih.gov/pubmed/37686062 http://dx.doi.org/10.3390/ijms241713264 |
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author | Yarkoni, Merav Rehman, Wajeeh ur Bajwa, Ata Yarkoni, Alon Rehman, Afzal ur |
author_facet | Yarkoni, Merav Rehman, Wajeeh ur Bajwa, Ata Yarkoni, Alon Rehman, Afzal ur |
author_sort | Yarkoni, Merav |
collection | PubMed |
description | Vasovagal syncope (VVS) refers to a heterogeneous group of conditions whereby the cardiovascular reflexes normally controlling the circulation are interrupted irregularly in response to a trigger, resulting in vasodilation, bradycardia, or both. VVS affects one-third of the population at least once in their lifetime or by the age of 60, reduces the quality of life, and may cause disability affecting certain routines. It poses a considerable economic burden on society, and, despite its prevalence, there is currently no proven pharmacological treatment for preventing VVS. The novel procedure of ganglionated plexus (GP) ablation has emerged rapidly in the past two decades, and has been proven successful in treating syncope. Several parameters influence the success rate of GP ablation, including specific ablation sites, localization and surgical techniques, method of access, and the integration of other interventions. This review aims to provide an overview of the existing literature on the physiological aspects and clinical effectiveness of GP ablation in the treatment of VVS. Specifically, we explore the association between GPs and VVS and examine the impact of GP ablation procedures as reported in human clinical trials. Our objective is to shed light on the therapeutic significance of GP ablation in eliminating VVS and restoring normal sinus rhythm, particularly among young adults affected by this condition. |
format | Online Article Text |
id | pubmed-10487499 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-104874992023-09-09 Ganglionated Plexus Ablation Procedures to Treat Vasovagal Syncope Yarkoni, Merav Rehman, Wajeeh ur Bajwa, Ata Yarkoni, Alon Rehman, Afzal ur Int J Mol Sci Review Vasovagal syncope (VVS) refers to a heterogeneous group of conditions whereby the cardiovascular reflexes normally controlling the circulation are interrupted irregularly in response to a trigger, resulting in vasodilation, bradycardia, or both. VVS affects one-third of the population at least once in their lifetime or by the age of 60, reduces the quality of life, and may cause disability affecting certain routines. It poses a considerable economic burden on society, and, despite its prevalence, there is currently no proven pharmacological treatment for preventing VVS. The novel procedure of ganglionated plexus (GP) ablation has emerged rapidly in the past two decades, and has been proven successful in treating syncope. Several parameters influence the success rate of GP ablation, including specific ablation sites, localization and surgical techniques, method of access, and the integration of other interventions. This review aims to provide an overview of the existing literature on the physiological aspects and clinical effectiveness of GP ablation in the treatment of VVS. Specifically, we explore the association between GPs and VVS and examine the impact of GP ablation procedures as reported in human clinical trials. Our objective is to shed light on the therapeutic significance of GP ablation in eliminating VVS and restoring normal sinus rhythm, particularly among young adults affected by this condition. MDPI 2023-08-26 /pmc/articles/PMC10487499/ /pubmed/37686062 http://dx.doi.org/10.3390/ijms241713264 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Yarkoni, Merav Rehman, Wajeeh ur Bajwa, Ata Yarkoni, Alon Rehman, Afzal ur Ganglionated Plexus Ablation Procedures to Treat Vasovagal Syncope |
title | Ganglionated Plexus Ablation Procedures to Treat Vasovagal Syncope |
title_full | Ganglionated Plexus Ablation Procedures to Treat Vasovagal Syncope |
title_fullStr | Ganglionated Plexus Ablation Procedures to Treat Vasovagal Syncope |
title_full_unstemmed | Ganglionated Plexus Ablation Procedures to Treat Vasovagal Syncope |
title_short | Ganglionated Plexus Ablation Procedures to Treat Vasovagal Syncope |
title_sort | ganglionated plexus ablation procedures to treat vasovagal syncope |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10487499/ https://www.ncbi.nlm.nih.gov/pubmed/37686062 http://dx.doi.org/10.3390/ijms241713264 |
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