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Noninvasive Neuromodulation in Parkinson’s Disease: Insights from Animal Models

The mainstay treatments for Parkinson’s Disease (PD) have been limited to pharmacotherapy and deep brain stimulation. While these interventions are helpful, a new wave of research is investigating noninvasive neuromodulation methods as potential treatments. Some promising avenues have included trans...

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Autores principales: Muksuris, Katherine, Scarisbrick, David M., Mahoney, James J., Cherkasova, Mariya V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10487610/
https://www.ncbi.nlm.nih.gov/pubmed/37685514
http://dx.doi.org/10.3390/jcm12175448
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author Muksuris, Katherine
Scarisbrick, David M.
Mahoney, James J.
Cherkasova, Mariya V.
author_facet Muksuris, Katherine
Scarisbrick, David M.
Mahoney, James J.
Cherkasova, Mariya V.
author_sort Muksuris, Katherine
collection PubMed
description The mainstay treatments for Parkinson’s Disease (PD) have been limited to pharmacotherapy and deep brain stimulation. While these interventions are helpful, a new wave of research is investigating noninvasive neuromodulation methods as potential treatments. Some promising avenues have included transcranial magnetic stimulation (TMS), transcranial direct current stimulation (tDCS), electroconvulsive therapy (ECT), and focused ultrasound (FUS). While these methods are being tested in PD patients, investigations in animal models of PD have sought to elucidate their therapeutic mechanisms. In this rapid review, we assess the available animal literature on these noninvasive techniques and discuss the possible mechanisms mediating their therapeutic effects based on these findings.
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spelling pubmed-104876102023-09-09 Noninvasive Neuromodulation in Parkinson’s Disease: Insights from Animal Models Muksuris, Katherine Scarisbrick, David M. Mahoney, James J. Cherkasova, Mariya V. J Clin Med Review The mainstay treatments for Parkinson’s Disease (PD) have been limited to pharmacotherapy and deep brain stimulation. While these interventions are helpful, a new wave of research is investigating noninvasive neuromodulation methods as potential treatments. Some promising avenues have included transcranial magnetic stimulation (TMS), transcranial direct current stimulation (tDCS), electroconvulsive therapy (ECT), and focused ultrasound (FUS). While these methods are being tested in PD patients, investigations in animal models of PD have sought to elucidate their therapeutic mechanisms. In this rapid review, we assess the available animal literature on these noninvasive techniques and discuss the possible mechanisms mediating their therapeutic effects based on these findings. MDPI 2023-08-22 /pmc/articles/PMC10487610/ /pubmed/37685514 http://dx.doi.org/10.3390/jcm12175448 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Muksuris, Katherine
Scarisbrick, David M.
Mahoney, James J.
Cherkasova, Mariya V.
Noninvasive Neuromodulation in Parkinson’s Disease: Insights from Animal Models
title Noninvasive Neuromodulation in Parkinson’s Disease: Insights from Animal Models
title_full Noninvasive Neuromodulation in Parkinson’s Disease: Insights from Animal Models
title_fullStr Noninvasive Neuromodulation in Parkinson’s Disease: Insights from Animal Models
title_full_unstemmed Noninvasive Neuromodulation in Parkinson’s Disease: Insights from Animal Models
title_short Noninvasive Neuromodulation in Parkinson’s Disease: Insights from Animal Models
title_sort noninvasive neuromodulation in parkinson’s disease: insights from animal models
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10487610/
https://www.ncbi.nlm.nih.gov/pubmed/37685514
http://dx.doi.org/10.3390/jcm12175448
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