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miRNAs Epigenetic Tuning of Wall Remodeling in the Early Phase after Myocardial Infarction: A Novel Epidrug Approach
Myocardial infarction (MI) is one of the leading causes of death in Western countries. An early diagnosis decreases subsequent severe complications such as wall remodeling or heart failure and improves treatments and interventions. Novel therapeutic targets have been recognized and, together with th...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10487654/ https://www.ncbi.nlm.nih.gov/pubmed/37686073 http://dx.doi.org/10.3390/ijms241713268 |
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author | Salvatori, Francesca D’Aversa, Elisabetta Serino, Maria Luisa Singh, Ajay Vikram Secchiero, Paola Zauli, Giorgio Tisato, Veronica Gemmati, Donato |
author_facet | Salvatori, Francesca D’Aversa, Elisabetta Serino, Maria Luisa Singh, Ajay Vikram Secchiero, Paola Zauli, Giorgio Tisato, Veronica Gemmati, Donato |
author_sort | Salvatori, Francesca |
collection | PubMed |
description | Myocardial infarction (MI) is one of the leading causes of death in Western countries. An early diagnosis decreases subsequent severe complications such as wall remodeling or heart failure and improves treatments and interventions. Novel therapeutic targets have been recognized and, together with the development of direct and indirect epidrugs, the role of non-coding RNAs (ncRNAs) yields great expectancy. ncRNAs are a group of RNAs not translated into a product and, among them, microRNAs (miRNAs) are the most investigated subgroup since they are involved in several pathological processes related to MI and post-MI phases such as inflammation, apoptosis, angiogenesis, and fibrosis. These processes and pathways are finely tuned by miRNAs via complex mechanisms. We are at the beginning of the investigation and the main paths are still underexplored. In this review, we provide a comprehensive discussion of the recent findings on epigenetic changes involved in the first phases after MI as well as on the role of the several miRNAs. We focused on miRNAs function and on their relationship with key molecules and cells involved in healing processes after an ischemic accident, while also giving insight into the discrepancy between males and females in the prognosis of cardiovascular diseases. |
format | Online Article Text |
id | pubmed-10487654 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-104876542023-09-09 miRNAs Epigenetic Tuning of Wall Remodeling in the Early Phase after Myocardial Infarction: A Novel Epidrug Approach Salvatori, Francesca D’Aversa, Elisabetta Serino, Maria Luisa Singh, Ajay Vikram Secchiero, Paola Zauli, Giorgio Tisato, Veronica Gemmati, Donato Int J Mol Sci Review Myocardial infarction (MI) is one of the leading causes of death in Western countries. An early diagnosis decreases subsequent severe complications such as wall remodeling or heart failure and improves treatments and interventions. Novel therapeutic targets have been recognized and, together with the development of direct and indirect epidrugs, the role of non-coding RNAs (ncRNAs) yields great expectancy. ncRNAs are a group of RNAs not translated into a product and, among them, microRNAs (miRNAs) are the most investigated subgroup since they are involved in several pathological processes related to MI and post-MI phases such as inflammation, apoptosis, angiogenesis, and fibrosis. These processes and pathways are finely tuned by miRNAs via complex mechanisms. We are at the beginning of the investigation and the main paths are still underexplored. In this review, we provide a comprehensive discussion of the recent findings on epigenetic changes involved in the first phases after MI as well as on the role of the several miRNAs. We focused on miRNAs function and on their relationship with key molecules and cells involved in healing processes after an ischemic accident, while also giving insight into the discrepancy between males and females in the prognosis of cardiovascular diseases. MDPI 2023-08-26 /pmc/articles/PMC10487654/ /pubmed/37686073 http://dx.doi.org/10.3390/ijms241713268 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Salvatori, Francesca D’Aversa, Elisabetta Serino, Maria Luisa Singh, Ajay Vikram Secchiero, Paola Zauli, Giorgio Tisato, Veronica Gemmati, Donato miRNAs Epigenetic Tuning of Wall Remodeling in the Early Phase after Myocardial Infarction: A Novel Epidrug Approach |
title | miRNAs Epigenetic Tuning of Wall Remodeling in the Early Phase after Myocardial Infarction: A Novel Epidrug Approach |
title_full | miRNAs Epigenetic Tuning of Wall Remodeling in the Early Phase after Myocardial Infarction: A Novel Epidrug Approach |
title_fullStr | miRNAs Epigenetic Tuning of Wall Remodeling in the Early Phase after Myocardial Infarction: A Novel Epidrug Approach |
title_full_unstemmed | miRNAs Epigenetic Tuning of Wall Remodeling in the Early Phase after Myocardial Infarction: A Novel Epidrug Approach |
title_short | miRNAs Epigenetic Tuning of Wall Remodeling in the Early Phase after Myocardial Infarction: A Novel Epidrug Approach |
title_sort | mirnas epigenetic tuning of wall remodeling in the early phase after myocardial infarction: a novel epidrug approach |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10487654/ https://www.ncbi.nlm.nih.gov/pubmed/37686073 http://dx.doi.org/10.3390/ijms241713268 |
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