Cargando…

Potential Association of Cytochrome P450 Copy Number Alteration in Tumour with Chemotherapy Resistance in Lung Adenocarcinoma Patients

Resistance to anticancer agents is a major obstacle to efficacious tumour therapy and responsible for high cancer-related mortality rates. Some resistance mechanisms are associated with pharmacokinetic variability in anticancer drug exposure due to genetic polymorphisms of drug-metabolizing cytochro...

Descripción completa

Detalles Bibliográficos
Autores principales:	Incze, Evelyn, Mangó, Katalin, Fekete, Ferenc, Kiss, Ádám Ferenc, Póti, Ádám, Harkó, Tünde, Moldvay, Judit, Szüts, Dávid, Monostory, Katalin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10487787/ https://www.ncbi.nlm.nih.gov/pubmed/37686184 http://dx.doi.org/10.3390/ijms241713380

Ejemplares similares

Impact of genetic and non-genetic factors on hepatic CYP2C9 expression and activity in Hungarian subjects
por: Fekete, Ferenc, et al.
Publicado: (2021)

CYP2B6 allelic variants and non-genetic factors influence CYP2B6 enzyme function
por: Mangó, Katalin, et al.
Publicado: (2022)

End-stage renal disease reduces the expression of drug-metabolizing cytochrome P450s
por: Déri, Máté Tamás, et al.
Publicado: (2020)

CYP3A-status is associated with blood concentration and dose-requirement of tacrolimus in heart transplant recipients
por: Déri, Máté, et al.
Publicado: (2021)

CYP1A2 mRNA Expression Rather than Genetic Variants Indicate Hepatic CYP1A2 Activity
por: Fekete, Ferenc, et al.
Publicado: (2022)

CYP1A2 expression rather than genotype is associated with olanzapine concentration in psychiatric patients
por: Fekete, Ferenc, et al.
Publicado: (2023)

Association between CYP2B6 genetic variability and cyclophosphamide therapy in pediatric patients with neuroblastoma
por: Mangó, Katalin, et al.
Publicado: (2023)

Association of clozapine-related metabolic disturbances with CYP3A4 expression in patients with schizophrenia
por: Menus, Ádám, et al.
Publicado: (2020)

Sustained in vitro interferon-beta release and in vivo toxicity of PLGA and PEG-PLGA nanoparticles
por: Fodor-Kardos, Andrea, et al.
Publicado: (2020)

Copy number variations of cytochrome P450 genes in Kinh Vietnamese
por: Vu, Nhung Phuong, et al.
Publicado: (2023)

Claudin expression in pulmonary adenoid cystic carcinoma and mucoepidermoid carcinoma
por: Gyulai, Marton, et al.
Publicado: (2023)

Editorial: Copy Number Variation in Rare Disorders
por: Komlósi, Katalin, et al.
Publicado: (2022)

Multi-ethnic Cytochrome-P450 Copy Number Profiling: Novel Pharmacogenetic Alleles and Mechanism of Copy Number Variation Formation
por: Martis, Suparna, et al.
Publicado: (2012)

Relevance of CYP2C9 Function in Valproate Therapy
por: Monostory, Katalin, et al.
Publicado: (2019)

Characterisation of the spectrum and genetic dependence of collateral mutations induced by translesion DNA synthesis
por: Póti, Ádám, et al.
Publicado: (2022)

CopyNumber450kCancer: baseline correction for accurate copy number calling from the 450k methylation array
por: Marzouka, Nour-al-dain, et al.
Publicado: (2016)

Normalization of Enzyme Expression and Activity Regulating Vitamin A Metabolism Increases RAR-Beta Expression and Reduces Cellular Migration and Proliferation in Diseases Caused by Tuberous Sclerosis Gene Mutations
por: Abdelwahab, Elhusseiny Mohamed Mahmoud, et al.
Publicado: (2021)

Optimization of Clonazepam Therapy Adjusted to Patient’s CYP3A Status and NAT2 Genotype
por: Tóth, Katalin, et al.
Publicado: (2016)

Potential Role of Patients’ CYP3A-Status in Clozapine Pharmacokinetics
por: Tóth, Katalin, et al.
Publicado: (2017)

A robust prognostic gene expression signature for early stage lung adenocarcinoma
por: Krzystanek, Marcin, et al.
Publicado: (2016)

Determination of Cytochrome P450 2D6 (CYP2D6) Gene Copy Number by Real-Time Quantitative PCR
por: Bodin, Laurent, et al.
Publicado: (2005)

PD-1 and PD-L1 expression in rare lung tumors
por: Gyulai, Marton, et al.
Publicado: (2023)

An Unprecedented Number of Cytochrome P450s Are Involved in Secondary Metabolism in Salinispora Species
por: Malinga, Nsikelelo Allison, et al.
Publicado: (2022)

EGFR variant allele frequency predicts EGFR-TKI efficacy in lung adenocarcinoma: a multicenter study
por: Gieszer, Balazs, et al.
Publicado: (2021)

The Cytochrome P450 Homepage
por: Nelson, David R
Publicado: (2009)

Probing the Role of the Hinge Segment of Cytochrome P450 Oxidoreductase in the Interaction with Cytochrome P450
por: Campelo, Diana, et al.
Publicado: (2018)

BGP-15 Protects against Oxidative Stress- or Lipopolysaccharide-Induced Mitochondrial Destabilization and Reduces Mitochondrial Production of Reactive Oxygen Species
por: Sumegi, Katalin, et al.
Publicado: (2017)

Uncovering of cytochrome P450 anatomy by SecStrAnnotator
por: Midlik, Adam, et al.
Publicado: (2021)

Establishment and Characterization of a Brca1(−/−), p53(−/−) Mouse Mammary Tumor Cell Line
por: Hámori, Lilla, et al.
Publicado: (2020)

Regulation of cytochrome P450 gene expression in human colon and breast tumour xenografts.
por: Smith, G., et al.
Publicado: (1993)

Regulation of cytochrome P450s in breast cancer and their role for tumour growth and anticancer chemotherapy
por: Friedberg, T, et al.
Publicado: (2006)

Evaluation and modulation of DNA lesion bypass in an SV40 large T antigen‐based in vitro replication system
por: Szeltner, Zoltán, et al.
Publicado: (2021)

In Vitro Pharmacokinetic Behavior of Antiviral 3-Amidinophenylalanine Derivatives in Rat, Dog and Monkey Hepatocytes
por: Lányi, Katalin, et al.
Publicado: (2023)

The FMN “140s Loop” of Cytochrome P450 Reductase Controls Electron Transfer to Cytochrome P450
por: Rwere, Freeborn, et al.
Publicado: (2021)

Wnt Activity and Cell Proliferation Are Coupled to Extracellular Vesicle Release in Multiple Organoid Models
por: Sándor, Gyöngyvér Orsolya, et al.
Publicado: (2021)

Copy number variations and cancer
por: Shlien, Adam, et al.
Publicado: (2009)

High-resolution genetic mapping reveals cis-regulatory and copy number variation in loci associated with cytochrome P450-mediated detoxification in a generalist arthropod pest
por: Fotoukkiaii, Seyedeh Masoumeh, et al.
Publicado: (2021)

Germline copy number variants are not associated with globally acquired copy number changes in familial breast tumours
por: Walker, Logan C., et al.
Publicado: (2012)

Fungal cytochrome P450 database
por: Park, Jongsun, et al.
Publicado: (2008)

Cytochrome P450 humanised mice
por: Gonzalez, Frank J
Publicado: (2004)

Cannot write session to /tmp/vufind_sessions/sess_p04ubr39e7ko3210v3dc0sj30r