Cargando…

BRD4 as a Therapeutic Target in Pulmonary Diseases

Bromodomain and extra-terminal domain (BET) proteins are epigenetic modulators that regulate gene transcription through interacting with acetylated lysine residues of histone proteins. BET proteins have multiple roles in regulating key cellular functions such as cell proliferation, differentiation,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Guo, Xia, Olajuyin, Ayobami, Tucker, Torry A., Idell, Steven, Qian, Guoqing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10487829/ https://www.ncbi.nlm.nih.gov/pubmed/37686037 http://dx.doi.org/10.3390/ijms241713231

Ejemplares similares

Update on Novel Targeted Therapy for Pleural Organization and Fibrosis
por: Tucker, Torry A., et al.
Publicado: (2022)

The Contribution of the Urokinase Plasminogen Activator and the Urokinase Receptor to Pleural and Parenchymal Lung Injury and Repair: A Narrative Review
por: Tucker, Torry A., et al.
Publicado: (2021)

Abdominal Aortic Aneurysm Formation with a Focus on Vascular Smooth Muscle Cells
por: Qian, Guoqing, et al.
Publicado: (2022)

PD-L1 mediates lung fibroblast to myofibroblast transition through Smad3 and β-catenin signaling pathways
por: Guo, Xia, et al.
Publicado: (2022)

CD146 T cells in lung cancer: its function, detection, and clinical implications as a biomarker and therapeutic target
por: Olajuyin, Ayobami Matthew, et al.
Publicado: (2019)

Inducible general knockout of Runx3 profoundly reduces pulmonary cytotoxic CD8(+) T cells with minimal effect on outcomes in mice following influenza infection
por: Hao, Qin, et al.
Publicado: (2022)

BRD4: An emerging prospective therapeutic target in glioma
por: Yang, Hua, et al.
Publicado: (2021)

Interferon-γ Preferentially Promotes Necroptosis of Lung Epithelial Cells by Upregulating MLKL
por: Hao, Qin, et al.
Publicado: (2022)

Glycogen Synthase Kinase-3β Inhibition with 9-ING-41 Attenuates the Progression of Pulmonary Fibrosis
por: Jeffers, Ann, et al.
Publicado: (2019)

Post-Translational Modifications of BRD4: Therapeutic Targets for Tumor
por: Liu, Na, et al.
Publicado: (2022)

Therapeutic Targeting of BRD4 in Head Neck Squamous Cell Carcinoma
por: Wu, Yaping, et al.
Publicado: (2019)

Myo5b Transports Fibronectin-Containing Vesicles and Facilitates FN1 Secretion from Human Pleural Mesothelial Cells
por: Sakai, Tsuyoshi, et al.
Publicado: (2022)

Alveolar type 2 progenitor cells for lung injury repair
por: Olajuyin, Ayobami Matthew, et al.
Publicado: (2019)

TGF-β regulation of the uPA/uPAR axis modulates mesothelial-mesenchymal transition (MesoMT)
por: Logan, Ranisha, et al.
Publicado: (2021)

BRD4 as a therapeutic target for nonfunctioning and growth hormone pituitary adenoma
por: Shi, Chengzhang, et al.
Publicado: (2020)

BRD4 is involved in viral exacerbation of chronic obstructive pulmonary disease
por: Duan, Yifei, et al.
Publicado: (2023)

Regulation of programmed cell death by Brd4
por: Hu, Jinfeng, et al.
Publicado: (2022)

Targeting Mechanotransduction at the Transcriptional Level: YAP and BRD4 Are Novel Therapeutic Targets for the Reversal of Liver Fibrosis
por: Zhubanchaliyev, Altynbek, et al.
Publicado: (2016)

BRD4 inhibition boosts the therapeutic effects of epidermal growth factor receptor-targeted chimeric antigen receptor T cells in glioblastoma
por: Xia, Lin, et al.
Publicado: (2021)

Combined targeting of HEDGEHOG signaling and BRD4 as a novel therapeutic option against melanoma
por: Pietrobono, Silvia, et al.
Publicado: (2023)

Preparation data of the bromodomains BRD3(1), BRD3(2), BRD4(1), and BRPF1B and crystallization of BRD4(1)-inhibitor complexes
por: Hügle, Martin, et al.
Publicado: (2016)

BRD4 inhibition for the treatment of pathological organ fibrosis
por: Stratton, Matthew S., et al.
Publicado: (2017)

Decreased Interleukin-1 Family Cytokine Production in Patients with Nontuberculous Mycobacterial Lung Disease
por: Jung, Bock-Gie, et al.
Publicado: (2022)

Early IL-17A production helps establish Mycobacterium intracellulare infection in mice
por: Jung, Bock-Gie, et al.
Publicado: (2022)

BRD4 and Cancer: going beyond transcriptional regulation
por: Donati, Benedetta, et al.
Publicado: (2018)

BRD4: a general regulator of transcription elongation
por: Altendorfer, Elisabeth, et al.
Publicado: (2022)

Bardoxolone conjugation enables targeted protein degradation of BRD4
por: Tong, Bingqi, et al.
Publicado: (2020)

BRD4 inhibitors block telomere elongation
por: Wang, Steven, et al.
Publicado: (2017)

BET inhibitor OTX015 targets BRD2 and BRD4 and decreases c-MYC in acute leukemia cells
por: Coudé, Marie-Magdelaine, et al.
Publicado: (2015)

Current Understanding of the Role of the Brd4 Protein in the Papillomavirus Lifecycle
por: McBride, Alison A., et al.
Publicado: (2013)

Caveolin-1-Related Intervention for Fibrotic Lung Diseases
por: Shetty, Sreerama, et al.
Publicado: (2023)

BRD4: A BET(ter) target for the treatment of AML?
por: Valent, Peter, et al.
Publicado: (2014)

Phosphorylation-dependent BRD4 dimerization and implications for therapeutic inhibition of BET family proteins
por: Malvezzi, Francesca, et al.
Publicado: (2021)

Increased expression of BRD4 isoforms long (BRD4-L) and short (BRD4-S) promotes chemotherapy resistance in high-grade serous ovarian carcinoma
por: Drumond-Bock, Ana Luiza, et al.
Publicado: (2023)

Organizing empyema induced in mice by Streptococcus pneumoniae: effects of plasminogen activator inhibitor-1 deficiency
por: Tucker, Torry A., et al.
Publicado: (2016)

Targeting BRD9 for Cancer Treatment: A New Strategy
por: Zhu, Xiuzuo, et al.
Publicado: (2020)

BRD3 and BRD4 BET Bromodomain Proteins Differentially Regulate Skeletal Myogenesis
por: Roberts, Thomas C., et al.
Publicado: (2017)

BET Bromodomain Proteins Brd2, Brd3 and Brd4 Selectively Regulate Metabolic Pathways in the Pancreatic β-Cell
por: Deeney, Jude T., et al.
Publicado: (2016)

Transcriptome analysis of dominant-negative Brd4 mutants identifies Brd4-specific target genes of small molecule inhibitor JQ1
por: Decker, Tim-Michael, et al.
Publicado: (2017)

Evaluating the bromodomain protein BRD1 as a therapeutic target in rheumatoid arthritis
por: Klein, Kerstin, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_q88l5qrjg8bfhptk9unh2nbaac