Pharmacological Inhibition and Genetic Deletion of Cystathionine Gamma-Lyase in Mice Protects against Organ Injury in Sepsis: A Key Role of Adhesion Molecules on Endothelial Cells

Hydrogen sulfide (H(2)S), synthesized by cystathionine gamma-lyase (Cth), contributes to the inflammatory response observed in sepsis. This study examines the effect of Cth-derived H(2)S in adhesion molecules on endothelial cells of vital organs in mice in a cecal ligation puncture (CLP)-induced mod...

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Detalles Bibliográficos
Autores principales: Manandhar, Sumeet, Chambers, Stephen, Miller, Andrew, Ishii, Isao, Bhatia, Madhav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10487872/
https://www.ncbi.nlm.nih.gov/pubmed/37686458
http://dx.doi.org/10.3390/ijms241713650

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10487872/
https://www.ncbi.nlm.nih.gov/pubmed/37686458
http://dx.doi.org/10.3390/ijms241713650

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