Cargando…

PD-L1 Downregulation and DNA Methylation Inhibition for Molecular Therapy against Cancer Stem Cells in Hepatocellular Carcinoma

Hepatocellular carcinoma (HCC) is a heterogeneous cancer characterized by various cellular subtypes. This study investigates the potential of a combination strategy using immunotherapy and epigenetic reprogramming against HCC. We used a transgenic HCC mouse C57BL/6J-TG(ALB1HBV)44BRI/J to assess the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sukowati, Caecilia, Cabral, Loraine Kay D., Anfuso, Beatrice, Dituri, Francesco, Negro, Roberto, Giannelli, Gianluigi, Tiribelli, Claudio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10487900/ https://www.ncbi.nlm.nih.gov/pubmed/37686163 http://dx.doi.org/10.3390/ijms241713357

Ejemplares similares

Network Analysis for the Discovery of Common Oncogenic Biomarkers in Liver Cancer Experimental Models
por: Cabral, Loraine Kay D., et al.
Publicado: (2023)

Sorafenib Resistance in Hepatocellular Carcinoma: The Relevance of Genetic Heterogeneity
por: Cabral, Loraine Kay D., et al.
Publicado: (2020)

The Relevance of SOCS1 Methylation and Epigenetic Therapy in Diverse Cell Populations of Hepatocellular Carcinoma
por: Cabral, Loraine Kay D., et al.
Publicado: (2021)

Circulating Long and Circular Noncoding RNA as Non-Invasive Diagnostic Tools of Hepatocellular Carcinoma
por: Sukowati, Caecilia H. C., et al.
Publicado: (2021)

The Expression of CD90/Thy-1 in Hepatocellular Carcinoma: An In Vivo and In Vitro Study
por: Sukowati, Caecilia Hapsari Ceriapuri, et al.
Publicado: (2013)

The role of multipotent cancer associated fibroblasts in hepatocarcinogenesis
por: Sukowati, Caecilia Hapsari Ceriapuri, et al.
Publicado: (2015)

Gene and functional up-regulation of the BCRP/ABCG2 transporter in hepatocellular carcinoma
por: Sukowati, Caecilia HC, et al.
Publicado: (2012)

Hyaluronic acid inhibition by 4-methylumbelliferone reduces the expression of cancer stem cells markers during hepatocarcinogenesis
por: Sukowati, Caecilia H. C., et al.
Publicado: (2019)

Activation of hepatic stem cells compartment during hepatocarcinogenesis in a HBsAg HBV-transgenic mouse model
por: Anfuso, Beatrice, et al.
Publicado: (2018)

Immunotherapy against programmed death-1/programmed death ligand 1 in hepatocellular carcinoma: Importance of molecular variations, cellular heterogeneity, and cancer stem cells
por: Sukowati, Caecilia H C, et al.
Publicado: (2021)

The mRNA Distribution of Cancer Stem Cell Marker CD90/Thy-1 Is Comparable in Hepatocellular Carcinoma of Eastern and Western Populations
por: Luong, An B., et al.
Publicado: (2020)

Aptamer: A potential oligonucleotide nanomedicine in the diagnosis and treatment of hepatocellular carcinoma
por: Ladju, Rusdina Bte, et al.
Publicado: (2017)

Correction: Aptamer: A potential oligonucleotide nanomedicine in the diagnosis and treatment of hepatocellular carcinoma
por: Ladju, Rusdina Bte, et al.
Publicado: (2018)

Role of hepatitis B virus in development of hepatocellular carcinoma: Focus on covalently closed circular DNA
por: Bianca, Claryssa, et al.
Publicado: (2022)

Serum Stem Cell Growth Factor Beta for the Prediction of Therapy Response in Hepatocellular Carcinoma
por: Sukowati, Caecilia H. C., et al.
Publicado: (2018)

MutL homolog 1 methylation and microsatellite instability in sporadic colorectal tumors among Filipinos
por: Cabral, Loraine Kay D, et al.
Publicado: (2021)

Biomarkers for the Detection and Management of Hepatocellular Carcinoma in Patients Treated with Direct-Acting Antivirals
por: Cabral, Loraine Kay D., et al.
Publicado: (2022)

Laminin-332 γ2 Monomeric Chain Promotes Adhesion and Migration of Hepatocellular Carcinoma Cells
por: Scialpi, Rosanna, et al.
Publicado: (2023)

Transforming Growth Factor-β Promotes Morphomechanical Effects Involved in Epithelial to Mesenchymal Transition in Living Hepatocellular Carcinoma
por: Cascione, Mariafrancesca, et al.
Publicado: (2018)

Impaired Anti-Tumor T cell Response in Hepatocellular Carcinoma
por: Chaoul, Nada, et al.
Publicado: (2020)

Proteoglycans in Cancer: Friends or Enemies? A Special Focus on Hepatocellular Carcinoma
por: Dituri, Francesco, et al.
Publicado: (2022)

The Expression Level of ABCC6 Transporter in Colon Cancer Cells Correlates with the Activation of Different Intracellular Signaling Pathways
por: Abruzzese, Vittorio, et al.
Publicado: (2022)

Serum AP-endonuclease 1 (sAPE1) as novel biomarker for hepatocellular carcinoma
por: Pascut, Devis, et al.
Publicado: (2019)

Obeticholic acid and INT-767 modulate collagen deposition in a NASH in vitro model
por: Anfuso, Beatrice, et al.
Publicado: (2020)

Validation of Hepatocellular Carcinoma Experimental Models for TGF-β Promoting Tumor Progression
por: Mancarella, Serena, et al.
Publicado: (2019)

Silybin Modulates Collagen Turnover in an In Vitro Model of NASH
por: Anfuso, Beatrice, et al.
Publicado: (2019)

Galunisertib suppresses the staminal phenotype in hepatocellular carcinoma by modulating CD44 expression
por: Rani, Bhavna, et al.
Publicado: (2018)

PI3K Functions in Cancer Progression, Anticancer Immunity and Immune Evasion by Tumors
por: Dituri, Francesco, et al.
Publicado: (2011)

The Interactivity between TGFβ and BMP Signaling in Organogenesis, Fibrosis, and Cancer
por: Dituri, Francesco, et al.
Publicado: (2019)

Updating the Clinical Application of Blood Biomarkers and Their Algorithms in the Diagnosis and Surveillance of Hepatocellular Carcinoma: A Critical Review
por: Shahini, Endrit, et al.
Publicado: (2023)

Calcium Regulates HCC Proliferation as well as EGFR Recycling/Degradation and Could Be a New Therapeutic Target in HCC
por: Modica, Teresa Maria Elisa, et al.
Publicado: (2019)

Artificial Intelligence and Complex Network Approaches Reveal Potential Gene Biomarkers for Hepatocellular Carcinoma
por: Lacalamita, Antonio, et al.
Publicado: (2023)

Epithelial–Mesenchymal Transition (EMT) Induced by TGF-β in Hepatocellular Carcinoma Cells Reprograms Lipid Metabolism
por: Soukupova, Jitka, et al.
Publicado: (2021)

Updates on Organoid Model for the Study of Liver Cancer
por: El-Khobar, Korri E., et al.
Publicado: (2023)

Autotaxin inhibitor IOA-289 reduces gastrointestinal cancer progression in preclinical models
por: Centonze, Matteo, et al.
Publicado: (2023)

Correction: Autotaxin inhibitor IOA-289 reduces gastrointestinal cancer progression in preclinical models
por: Centonze, Matteo, et al.
Publicado: (2023)

Validation of a Lab-on-Chip Assay for Measuring Sorafenib Effectiveness on HCC Cell Proliferation
por: Piccinno, Emanuele, et al.
Publicado: (2021)

Dietary ω-3 Polyunsaturated Fatty Acids Inhibit Tumor Growth in Transgenic Apc(Min/+) Mice, Correlating with CB1 Receptor Up-Regulation
por: Notarnicola, Maria, et al.
Publicado: (2017)

TGF-β and the Tissue Microenvironment: Relevance in Fibrosis and Cancer
por: Caja, Laia, et al.
Publicado: (2018)

NGS-based transcriptome profiling reveals biomarkers for companion diagnostics of the TGF-β receptor blocker galunisertib in HCC
por: Cao, Yuan, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_alierbt6jp9p16p6f4tukdocnq