Cargando…

Long-Term Effects of ART on the Health of the Offspring

Assisted reproductive technologies (ART) significantly increase the chance of successful pregnancy and live birth in infertile couples. The different procedures for ART, including in vitro fertilization (IVF), intracytoplasmic sperm injection (ICSI), intrauterine insemination (IUI), and gamete intra...

Descripción completa

Detalles Bibliográficos
Autores principales: Ahmadi, Hamid, Aghebati-Maleki, Leili, Rashidiani, Shima, Csabai, Timea, Nnaemeka, Obodo Basil, Szekeres-Bartho, Julia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10487905/
https://www.ncbi.nlm.nih.gov/pubmed/37686370
http://dx.doi.org/10.3390/ijms241713564
_version_ 1785103352244207616
author Ahmadi, Hamid
Aghebati-Maleki, Leili
Rashidiani, Shima
Csabai, Timea
Nnaemeka, Obodo Basil
Szekeres-Bartho, Julia
author_facet Ahmadi, Hamid
Aghebati-Maleki, Leili
Rashidiani, Shima
Csabai, Timea
Nnaemeka, Obodo Basil
Szekeres-Bartho, Julia
author_sort Ahmadi, Hamid
collection PubMed
description Assisted reproductive technologies (ART) significantly increase the chance of successful pregnancy and live birth in infertile couples. The different procedures for ART, including in vitro fertilization (IVF), intracytoplasmic sperm injection (ICSI), intrauterine insemination (IUI), and gamete intrafallopian tube transfer (GIFT), are widely used to overcome infertility-related problems. In spite of its inarguable usefulness, concerns about the health consequences of ART-conceived babies have been raised. There are reports about the association of ART with birth defects and health complications, e.g., malignancies, high blood pressure, generalized vascular functional disorders, asthma and metabolic disorders in later life. It has been suggested that hormonal treatment of the mother, and the artificial environment during the manipulation of gametes and embryos may cause genomic and epigenetic alterations and subsequent complications in the health status of ART-conceived babies. In the current study, we aimed to review the possible long-term consequences of different ART procedures on the subsequent health status of ART-conceived offspring, considering the confounding factors that might account for/contribute to the long-term consequences.
format Online
Article
Text
id pubmed-10487905
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-104879052023-09-09 Long-Term Effects of ART on the Health of the Offspring Ahmadi, Hamid Aghebati-Maleki, Leili Rashidiani, Shima Csabai, Timea Nnaemeka, Obodo Basil Szekeres-Bartho, Julia Int J Mol Sci Review Assisted reproductive technologies (ART) significantly increase the chance of successful pregnancy and live birth in infertile couples. The different procedures for ART, including in vitro fertilization (IVF), intracytoplasmic sperm injection (ICSI), intrauterine insemination (IUI), and gamete intrafallopian tube transfer (GIFT), are widely used to overcome infertility-related problems. In spite of its inarguable usefulness, concerns about the health consequences of ART-conceived babies have been raised. There are reports about the association of ART with birth defects and health complications, e.g., malignancies, high blood pressure, generalized vascular functional disorders, asthma and metabolic disorders in later life. It has been suggested that hormonal treatment of the mother, and the artificial environment during the manipulation of gametes and embryos may cause genomic and epigenetic alterations and subsequent complications in the health status of ART-conceived babies. In the current study, we aimed to review the possible long-term consequences of different ART procedures on the subsequent health status of ART-conceived offspring, considering the confounding factors that might account for/contribute to the long-term consequences. MDPI 2023-09-01 /pmc/articles/PMC10487905/ /pubmed/37686370 http://dx.doi.org/10.3390/ijms241713564 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ahmadi, Hamid
Aghebati-Maleki, Leili
Rashidiani, Shima
Csabai, Timea
Nnaemeka, Obodo Basil
Szekeres-Bartho, Julia
Long-Term Effects of ART on the Health of the Offspring
title Long-Term Effects of ART on the Health of the Offspring
title_full Long-Term Effects of ART on the Health of the Offspring
title_fullStr Long-Term Effects of ART on the Health of the Offspring
title_full_unstemmed Long-Term Effects of ART on the Health of the Offspring
title_short Long-Term Effects of ART on the Health of the Offspring
title_sort long-term effects of art on the health of the offspring
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10487905/
https://www.ncbi.nlm.nih.gov/pubmed/37686370
http://dx.doi.org/10.3390/ijms241713564
work_keys_str_mv AT ahmadihamid longtermeffectsofartonthehealthoftheoffspring
AT aghebatimalekileili longtermeffectsofartonthehealthoftheoffspring
AT rashidianishima longtermeffectsofartonthehealthoftheoffspring
AT csabaitimea longtermeffectsofartonthehealthoftheoffspring
AT nnaemekaobodobasil longtermeffectsofartonthehealthoftheoffspring
AT szekeresbarthojulia longtermeffectsofartonthehealthoftheoffspring