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Long-Term Effects of ART on the Health of the Offspring
Assisted reproductive technologies (ART) significantly increase the chance of successful pregnancy and live birth in infertile couples. The different procedures for ART, including in vitro fertilization (IVF), intracytoplasmic sperm injection (ICSI), intrauterine insemination (IUI), and gamete intra...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10487905/ https://www.ncbi.nlm.nih.gov/pubmed/37686370 http://dx.doi.org/10.3390/ijms241713564 |
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author | Ahmadi, Hamid Aghebati-Maleki, Leili Rashidiani, Shima Csabai, Timea Nnaemeka, Obodo Basil Szekeres-Bartho, Julia |
author_facet | Ahmadi, Hamid Aghebati-Maleki, Leili Rashidiani, Shima Csabai, Timea Nnaemeka, Obodo Basil Szekeres-Bartho, Julia |
author_sort | Ahmadi, Hamid |
collection | PubMed |
description | Assisted reproductive technologies (ART) significantly increase the chance of successful pregnancy and live birth in infertile couples. The different procedures for ART, including in vitro fertilization (IVF), intracytoplasmic sperm injection (ICSI), intrauterine insemination (IUI), and gamete intrafallopian tube transfer (GIFT), are widely used to overcome infertility-related problems. In spite of its inarguable usefulness, concerns about the health consequences of ART-conceived babies have been raised. There are reports about the association of ART with birth defects and health complications, e.g., malignancies, high blood pressure, generalized vascular functional disorders, asthma and metabolic disorders in later life. It has been suggested that hormonal treatment of the mother, and the artificial environment during the manipulation of gametes and embryos may cause genomic and epigenetic alterations and subsequent complications in the health status of ART-conceived babies. In the current study, we aimed to review the possible long-term consequences of different ART procedures on the subsequent health status of ART-conceived offspring, considering the confounding factors that might account for/contribute to the long-term consequences. |
format | Online Article Text |
id | pubmed-10487905 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-104879052023-09-09 Long-Term Effects of ART on the Health of the Offspring Ahmadi, Hamid Aghebati-Maleki, Leili Rashidiani, Shima Csabai, Timea Nnaemeka, Obodo Basil Szekeres-Bartho, Julia Int J Mol Sci Review Assisted reproductive technologies (ART) significantly increase the chance of successful pregnancy and live birth in infertile couples. The different procedures for ART, including in vitro fertilization (IVF), intracytoplasmic sperm injection (ICSI), intrauterine insemination (IUI), and gamete intrafallopian tube transfer (GIFT), are widely used to overcome infertility-related problems. In spite of its inarguable usefulness, concerns about the health consequences of ART-conceived babies have been raised. There are reports about the association of ART with birth defects and health complications, e.g., malignancies, high blood pressure, generalized vascular functional disorders, asthma and metabolic disorders in later life. It has been suggested that hormonal treatment of the mother, and the artificial environment during the manipulation of gametes and embryos may cause genomic and epigenetic alterations and subsequent complications in the health status of ART-conceived babies. In the current study, we aimed to review the possible long-term consequences of different ART procedures on the subsequent health status of ART-conceived offspring, considering the confounding factors that might account for/contribute to the long-term consequences. MDPI 2023-09-01 /pmc/articles/PMC10487905/ /pubmed/37686370 http://dx.doi.org/10.3390/ijms241713564 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Ahmadi, Hamid Aghebati-Maleki, Leili Rashidiani, Shima Csabai, Timea Nnaemeka, Obodo Basil Szekeres-Bartho, Julia Long-Term Effects of ART on the Health of the Offspring |
title | Long-Term Effects of ART on the Health of the Offspring |
title_full | Long-Term Effects of ART on the Health of the Offspring |
title_fullStr | Long-Term Effects of ART on the Health of the Offspring |
title_full_unstemmed | Long-Term Effects of ART on the Health of the Offspring |
title_short | Long-Term Effects of ART on the Health of the Offspring |
title_sort | long-term effects of art on the health of the offspring |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10487905/ https://www.ncbi.nlm.nih.gov/pubmed/37686370 http://dx.doi.org/10.3390/ijms241713564 |
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