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Meiotic Cell Cycle Progression in Mouse Oocytes: Role of Cyclins

All eukaryotic cells, including oocytes, utilize an engine called cyclin-dependent kinase (Cdk) to drive the cell cycle. Cdks are activated by a co-factor called cyclin, which regulates their activity. The key Cdk–cyclin complex that regulates the oocyte cell cycle is known as Cdk1–cyclin B1. Recent...

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Autores principales: Kim, Hye Min, Kang, Min Kook, Seong, Se Yoon, Jo, Jun Hyeon, Kim, Min Ju, Shin, Eun Kyeong, Lee, Chang Geun, Han, Seung Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10487953/
https://www.ncbi.nlm.nih.gov/pubmed/37686466
http://dx.doi.org/10.3390/ijms241713659
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author Kim, Hye Min
Kang, Min Kook
Seong, Se Yoon
Jo, Jun Hyeon
Kim, Min Ju
Shin, Eun Kyeong
Lee, Chang Geun
Han, Seung Jin
author_facet Kim, Hye Min
Kang, Min Kook
Seong, Se Yoon
Jo, Jun Hyeon
Kim, Min Ju
Shin, Eun Kyeong
Lee, Chang Geun
Han, Seung Jin
author_sort Kim, Hye Min
collection PubMed
description All eukaryotic cells, including oocytes, utilize an engine called cyclin-dependent kinase (Cdk) to drive the cell cycle. Cdks are activated by a co-factor called cyclin, which regulates their activity. The key Cdk–cyclin complex that regulates the oocyte cell cycle is known as Cdk1–cyclin B1. Recent studies have elucidated the roles of other cyclins, such as B2, B3, A2, and O, in oocyte cell cycle regulation. This review aims to discuss the recently discovered roles of various cyclins in mouse oocyte cell cycle regulation in accordance with the sequential progression of the cell cycle. In addition, this review addresses the translation and degradation of cyclins to modulate the activity of Cdks. Overall, the literature indicates that each cyclin performs unique and redundant functions at various stages of the cell cycle, while their expression and degradation are tightly regulated. Taken together, this review provides new insights into the regulatory role and function of cyclins in oocyte cell cycle progression.
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spelling pubmed-104879532023-09-09 Meiotic Cell Cycle Progression in Mouse Oocytes: Role of Cyclins Kim, Hye Min Kang, Min Kook Seong, Se Yoon Jo, Jun Hyeon Kim, Min Ju Shin, Eun Kyeong Lee, Chang Geun Han, Seung Jin Int J Mol Sci Review All eukaryotic cells, including oocytes, utilize an engine called cyclin-dependent kinase (Cdk) to drive the cell cycle. Cdks are activated by a co-factor called cyclin, which regulates their activity. The key Cdk–cyclin complex that regulates the oocyte cell cycle is known as Cdk1–cyclin B1. Recent studies have elucidated the roles of other cyclins, such as B2, B3, A2, and O, in oocyte cell cycle regulation. This review aims to discuss the recently discovered roles of various cyclins in mouse oocyte cell cycle regulation in accordance with the sequential progression of the cell cycle. In addition, this review addresses the translation and degradation of cyclins to modulate the activity of Cdks. Overall, the literature indicates that each cyclin performs unique and redundant functions at various stages of the cell cycle, while their expression and degradation are tightly regulated. Taken together, this review provides new insights into the regulatory role and function of cyclins in oocyte cell cycle progression. MDPI 2023-09-04 /pmc/articles/PMC10487953/ /pubmed/37686466 http://dx.doi.org/10.3390/ijms241713659 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kim, Hye Min
Kang, Min Kook
Seong, Se Yoon
Jo, Jun Hyeon
Kim, Min Ju
Shin, Eun Kyeong
Lee, Chang Geun
Han, Seung Jin
Meiotic Cell Cycle Progression in Mouse Oocytes: Role of Cyclins
title Meiotic Cell Cycle Progression in Mouse Oocytes: Role of Cyclins
title_full Meiotic Cell Cycle Progression in Mouse Oocytes: Role of Cyclins
title_fullStr Meiotic Cell Cycle Progression in Mouse Oocytes: Role of Cyclins
title_full_unstemmed Meiotic Cell Cycle Progression in Mouse Oocytes: Role of Cyclins
title_short Meiotic Cell Cycle Progression in Mouse Oocytes: Role of Cyclins
title_sort meiotic cell cycle progression in mouse oocytes: role of cyclins
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10487953/
https://www.ncbi.nlm.nih.gov/pubmed/37686466
http://dx.doi.org/10.3390/ijms241713659
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