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Native Renal Arteries Denervation as a Therapy of Refractory Hypertension in Patient after Heart and Kidney Transplantation—5 Years of Observation

This case report describes a 59-year-old male patient after heart and kidney transplantation, subsequently diagnosed with refractory hypertension since implemented antihypertensive pharmacotherapy consisting of six agents did not provide a substantial therapeutic response. Elevated blood pressure an...

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Detalles Bibliográficos
Autores principales: Pilch, Justyna, Mizera, Jakub, Wiśnicki, Krzysztof, Protasiewicz, Marcin, Kurcz, Jacek, Zmonarski, Sławomir, Wawrzonkowski, Patryk, Letachowicz, Krzysztof, Kamińska, Dorota, Gołębiowski, Tomasz, Zakliczyński, Michał, Krajewska, Magdalena, Banasik, Mirosław
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10487959/
https://www.ncbi.nlm.nih.gov/pubmed/37685525
http://dx.doi.org/10.3390/jcm12175458
Descripción
Sumario:This case report describes a 59-year-old male patient after heart and kidney transplantation, subsequently diagnosed with refractory hypertension since implemented antihypertensive pharmacotherapy consisting of six agents did not provide a substantial therapeutic response. Elevated blood pressure and its impact on a hypertrophied transplanted heart and impaired renal graft function have led to a significant deterioration in the patient’s cardiovascular risk profile. To address this issue, a native renal arteries denervation was performed. It resulted in a noteworthy decrease in both systolic and diastolic pressure values, thus manifesting a positive hypotensive effect. Furthermore, a sustainable reduction of left ventricular mass and stabilization in kidney graft function were noticed. The presented case provides evidence that renal denervation can be an efficacious complementary treatment method in individuals who received kidney and heart grafts as it leads to a decrease in cardiovascular risk.