Cargando…

Antiplatelet Effects of Selected Xanthine-Based Adenosine A(2A) and A(2B) Receptor Antagonists Determined in Rat Blood

The platelet aggregation inhibitory activity of selected xanthine-based adenosine A(2A) and A(2B) receptor antagonists was investigated, and attempts were made to explain the observed effects. The selective A(2B) receptor antagonist PSB-603 and the A(2A) receptor antagonist TB-42 inhibited platelet...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kubacka, Monika, Mogilski, Szczepan, Bednarski, Marek, Pociecha, Krzysztof, Świerczek, Artur, Nicosia, Noemi, Schabikowski, Jakub, Załuski, Michał, Chłoń-Rzepa, Grażyna, Hockemeyer, Jörg, Müller, Christa E., Kieć-Kononowicz, Katarzyna, Kotańska, Magdalena
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10487961/ https://www.ncbi.nlm.nih.gov/pubmed/37686188 http://dx.doi.org/10.3390/ijms241713378

Ejemplares similares

The GPR18 Agonist PSB-KD-107 Exerts Endothelium-Dependent Vasorelaxant Effects
por: Kotańska, Magdalena, et al.
Publicado: (2021)

Preliminary Evidence of the Potent and Selective Adenosine A2B Receptor Antagonist PSB-603 in Reducing Obesity and Some of Its Associated Metabolic Disorders in Mice
por: Kotańska, Magdalena, et al.
Publicado: (2022)

Efficacy of the Multi-Target Compound E153 in Relieving Pain and Pruritus of Different Origins
por: Mogilski, Szczepan, et al.
Publicado: (2023)

KSK-74: Dual Histamine H(3) and Sigma-2 Receptor Ligand with Anti-Obesity Potential
por: Mika, Kamil, et al.
Publicado: (2022)

Evaluation of analgesic and anti-inflammatory activity of purine-2,6-dione-based TRPA1 antagonists with PDE4/7 inhibitory activity
por: Zygmunt, Małgorzata, et al.
Publicado: (2022)

Pharmacokinetic/Pharmacodynamic Evaluation of a New Purine-2,6-Dione Derivative in Rodents with Experimental Autoimmune Diseases
por: Świerczek, Artur, et al.
Publicado: (2022)

Probing Substituents in the 1- and 3-Position: Tetrahydropyrazino-Annelated Water-Soluble Xanthine Derivatives as Multi-Target Drugs With Potent Adenosine Receptor Antagonistic Activity
por: Koch, Pierre, et al.
Publicado: (2018)

Manifestations of Liver Impairment and the Effects of MH-76, a Non-Quinazoline α1-Adrenoceptor Antagonist, and Prazosin on Liver Tissue in Fructose-Induced Metabolic Syndrome
por: Kubacka, Monika, et al.
Publicado: (2023)

Histamine H(3) Receptor Ligands—KSK-59 and KSK-73—Reduce Body Weight Gain in a Rat Model of Excessive Eating
por: Mika, Kamil, et al.
Publicado: (2021)

Effects of GPR18 Ligands on Body Weight and Metabolic Parameters in a Female Rat Model of Excessive Eating
por: Kotańska, Magdalena, et al.
Publicado: (2021)

KD-64—A new selective A(2A) adenosine receptor antagonist has anti-inflammatory activity but contrary to the non-selective antagonist—Caffeine does not reduce diet-induced obesity in mice
por: Kotańska, Magdalena, et al.
Publicado: (2020)

Comparative Assessment of the New PDE7 Inhibitor – GRMS-55 and Lisofylline in Animal Models of Immune-Related Disorders: A PK/PD Modeling Approach
por: Świerczek, Artur, et al.
Publicado: (2020)

Xanthine–Dopamine Hybrid Molecules as Multitarget Drugs with Potential for the Treatment of Neurodegenerative Diseases
por: Załuski, Michał, et al.
Publicado: (2023)

PK/PD Modeling of the PDE7 Inhibitor—GRMS-55 in a Mouse Model of Autoimmune Hepatitis
por: Świerczek, Artur, et al.
Publicado: (2021)

Aryl-1,3,5-triazine ligands of histamine H(4) receptor attenuate inflammatory and nociceptive response to carrageen, zymosan and lipopolysaccharide
por: Mogilski, Szczepan, et al.
Publicado: (2016)

MH-76, a Novel Non-Quinazoline α(1)-Adrenoceptor Antagonist, but Not Prazosin Reduces Inflammation and Improves Insulin Signaling in Adipose Tissue of Fructose-Fed Rats
por: Kubacka, Monika, et al.
Publicado: (2021)

Evaluation of Some Safety Parameters of Dual Histamine H(3) and Sigma-2 Receptor Ligands with Anti-Obesity Potential
por: Mika, Kamil, et al.
Publicado: (2023)

A Novel, Pan-PDE Inhibitor Exerts Anti-Fibrotic Effects in Human Lung Fibroblasts via Inhibition of TGF-β Signaling and Activation of cAMP/PKA Signaling
por: Wójcik-Pszczoła, Katarzyna, et al.
Publicado: (2020)

Trisubstituted 1,3,5-Triazines as Histamine H(4) Receptor Antagonists with Promising Activity In Vivo
por: Olejarz-Maciej, Agnieszka, et al.
Publicado: (2023)

Microwave-assisted ring closure reactions: Synthesis of 8-substituted xanthine derivatives and related pyrimido- and diazepinopurinediones
por: Burbiel, Joachim C, et al.
Publicado: (2006)

Pan-Phosphodiesterase Inhibitors Attenuate TGF-β-Induced Pro-Fibrotic Phenotype in Alveolar Epithelial Type II Cells by Downregulating Smad-2 Phosphorylation
por: Wójcik-Pszczoła, Katarzyna, et al.
Publicado: (2022)

Synthesis and biological evaluation of N-arylpiperazine derivatives of 4,4-dimethylisoquinoline-1,3(2H,4H)-dione as potential antiplatelet agents
por: Marcinkowska, Monika, et al.
Publicado: (2018)

The histamine H(3) receptor inverse agonist pitolisant reduces body weight in obese mice
por: Kotańska, Magdalena, et al.
Publicado: (2018)

Synthesis and Properties of a New Water-Soluble Prodrug of the Adenosine A(2A) Receptor Antagonist MSX-2
por: Vollmann, Karl, et al.
Publicado: (2008)

A Taxicab geometry quantification system to evaluate the performance of in silico methods: a case study on adenosine receptors ligands
por: Kuder, Kamil J., et al.
Publicado: (2020)

Adenosine Deaminase, Nucleoside Phosphorylase and Xanthine Oxidase in Liver Tumours
por: Reid, E., et al.
Publicado: (1957)

Anti-Inflammatory Activities of 8-Benzylaminoxanthines Showing High Adenosine A(2A) and Dual A(1)/A(2A) Receptor Affinity
por: Załuski, Michał, et al.
Publicado: (2023)

Synthesis of Novel Fluorinated Xanthine Derivatives with High Adenosine A(2B) Receptor Binding Affinity
por: Lindemann, Marcel, et al.
Publicado: (2021)

Discovery of Potential, Dual-Active Histamine H(3) Receptor Ligands with Combined Antioxidant Properties
por: Kuder, Kamil J., et al.
Publicado: (2021)

In Vitro Biotransformation, Safety, and Chemopreventive Action of Novel 8-Methoxy-Purine-2,6-Dione Derivatives
por: Marć, Małgorzata Anna, et al.
Publicado: (2017)

Biphenylalkoxyamine Derivatives–Histamine H(3) Receptor Ligands with Butyrylcholinesterase Inhibitory Activity
por: Łażewska, Dorota, et al.
Publicado: (2021)

Hydroalcoholic Leaf Extract of Isatis tinctoria L. via Antioxidative and Anti-Inflammatory Effects Reduces Stress-Induced Behavioral and Cellular Disorders in Mice
por: Nicosia, Noemi, et al.
Publicado: (2022)

H(3) histamine receptor antagonist pitolisant reverses some subchronic disturbances induced by olanzapine in mice
por: Dudek, Magdalena, et al.
Publicado: (2016)

Determination of serum adenosine deaminase and xanthine oxidase activity in Kangal dogs with maternal cannibalism
por: Ercan, N., et al.
Publicado: (2017)

Species Differences in Microsomal Metabolism of Xanthine-Derived A(1) Adenosine Receptor Ligands
por: Schneider, Daniela, et al.
Publicado: (2021)

Novel GPR18 Ligands in Rodent Pharmacological Tests: Effects on Mood, Pain, and Eating Disorders
por: Frankowska, Małgorzata, et al.
Publicado: (2023)

Physiologically based modeling of lisofylline pharmacokinetics following intravenous administration in mice
por: Wyska, Elżbieta, et al.
Publicado: (2015)

Xanthine urolithiasis: Inhibitors of xanthine crystallization
por: Grases, Felix, et al.
Publicado: (2018)

Efflux Pump Blockers in Gram-Negative Bacteria: The New Generation of Hydantoin Based-Modulators to Improve Antibiotic Activity
por: Otręebska-Machaj, Ewa, et al.
Publicado: (2016)

Guanabenz—an old drug with a potential to decrease obesity
por: Kotańska, Magdalena, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_sfjf3rmmo67oq8to4jq77mjb83