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Imprinted Long Non-Coding RNAs in Mammalian Development and Disease

Imprinted genes play diverse roles in mammalian development, homeostasis, and disease. Most imprinted chromosomal domains express one or more long non-coding RNAs (lncRNAs). Several of these lncRNAs are strictly nuclear and their mono-allelic expression controls in cis the expression of protein-codi...

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Autores principales: Di Michele, Flavio, Chillón, Isabel, Feil, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10487962/
https://www.ncbi.nlm.nih.gov/pubmed/37686455
http://dx.doi.org/10.3390/ijms241713647
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author Di Michele, Flavio
Chillón, Isabel
Feil, Robert
author_facet Di Michele, Flavio
Chillón, Isabel
Feil, Robert
author_sort Di Michele, Flavio
collection PubMed
description Imprinted genes play diverse roles in mammalian development, homeostasis, and disease. Most imprinted chromosomal domains express one or more long non-coding RNAs (lncRNAs). Several of these lncRNAs are strictly nuclear and their mono-allelic expression controls in cis the expression of protein-coding genes, often developmentally regulated. Some imprinted lncRNAs act in trans as well, controlling target gene expression elsewhere in the genome. The regulation of imprinted gene expression—including that of imprinted lncRNAs—is susceptible to stochastic and environmentally triggered epigenetic changes in the early embryo. These aberrant changes persist during subsequent development and have long-term phenotypic consequences. This review focuses on the expression and the cis- and trans-regulatory roles of imprinted lncRNAs and describes human disease syndromes associated with their perturbed expression.
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spelling pubmed-104879622023-09-09 Imprinted Long Non-Coding RNAs in Mammalian Development and Disease Di Michele, Flavio Chillón, Isabel Feil, Robert Int J Mol Sci Review Imprinted genes play diverse roles in mammalian development, homeostasis, and disease. Most imprinted chromosomal domains express one or more long non-coding RNAs (lncRNAs). Several of these lncRNAs are strictly nuclear and their mono-allelic expression controls in cis the expression of protein-coding genes, often developmentally regulated. Some imprinted lncRNAs act in trans as well, controlling target gene expression elsewhere in the genome. The regulation of imprinted gene expression—including that of imprinted lncRNAs—is susceptible to stochastic and environmentally triggered epigenetic changes in the early embryo. These aberrant changes persist during subsequent development and have long-term phenotypic consequences. This review focuses on the expression and the cis- and trans-regulatory roles of imprinted lncRNAs and describes human disease syndromes associated with their perturbed expression. MDPI 2023-09-04 /pmc/articles/PMC10487962/ /pubmed/37686455 http://dx.doi.org/10.3390/ijms241713647 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Di Michele, Flavio
Chillón, Isabel
Feil, Robert
Imprinted Long Non-Coding RNAs in Mammalian Development and Disease
title Imprinted Long Non-Coding RNAs in Mammalian Development and Disease
title_full Imprinted Long Non-Coding RNAs in Mammalian Development and Disease
title_fullStr Imprinted Long Non-Coding RNAs in Mammalian Development and Disease
title_full_unstemmed Imprinted Long Non-Coding RNAs in Mammalian Development and Disease
title_short Imprinted Long Non-Coding RNAs in Mammalian Development and Disease
title_sort imprinted long non-coding rnas in mammalian development and disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10487962/
https://www.ncbi.nlm.nih.gov/pubmed/37686455
http://dx.doi.org/10.3390/ijms241713647
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