A Clinically Relevant Dosage of Mitoxantrone Disrupts the Glutathione and Lipid Metabolic Pathways of the CD-1 Mice Brain: A Metabolomics Study

Long-term cognitive dysfunction, or “chemobrain”, has been observed in cancer patients treated with chemotherapy. Mitoxantrone (MTX) is a topoisomerase II inhibitor that binds and intercalates with DNA, being used in the treatment of several cancers and multiple sclerosis. Although MTX can induce ch...

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Detalles Bibliográficos
Autores principales: Dias-Carvalho, Ana, Margarida-Araújo, Ana, Reis-Mendes, Ana, Sequeira, Catarina Oliveira, Pereira, Sofia Azeredo, Guedes de Pinho, Paula, Carvalho, Félix, Sá, Susana Isabel, Fernandes, Eduarda, Costa, Vera Marisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10488007/
https://www.ncbi.nlm.nih.gov/pubmed/37685929
http://dx.doi.org/10.3390/ijms241713126

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10488007/
https://www.ncbi.nlm.nih.gov/pubmed/37685929
http://dx.doi.org/10.3390/ijms241713126

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