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Latest Research of Doped Hydroxyapatite for Bone Tissue Engineering
Bone tissue engineering has attracted great interest in the last few years, as the frequency of tissue-damaging or degenerative diseases has increased exponentially. To obtain an ideal treatment solution, researchers have focused on the development of optimum biomaterials to be applied for the enhan...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10488011/ https://www.ncbi.nlm.nih.gov/pubmed/37685968 http://dx.doi.org/10.3390/ijms241713157 |
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author | Radulescu, Diana-Elena Vasile, Otilia Ruxandra Andronescu, Ecaterina Ficai, Anton |
author_facet | Radulescu, Diana-Elena Vasile, Otilia Ruxandra Andronescu, Ecaterina Ficai, Anton |
author_sort | Radulescu, Diana-Elena |
collection | PubMed |
description | Bone tissue engineering has attracted great interest in the last few years, as the frequency of tissue-damaging or degenerative diseases has increased exponentially. To obtain an ideal treatment solution, researchers have focused on the development of optimum biomaterials to be applied for the enhancement of bioactivity and the regeneration process, which are necessary to support the proper healing process of osseous tissues. In this regard, hydroxyapatite (HA) has been the most widely used material in the biomedical field due to its great biocompatibility and similarity with the native apatite from the human bone. However, HA still presents some deficiencies related to its mechanical properties, which are essential for HA to be applied in load-bearing applications. Bioactivity is another vital property of HA and is necessary to further improve regeneration and antibacterial activity. These drawbacks can be solved by doping the material with trace elements, adapting the properties of the material, and, finally, sustaining bone regeneration without the occurrence of implant failure. Considering these aspects, in this review, we have presented some general information about HA properties, synthesis methods, applications, and the necessity for the addition of doping ions into its structure. Also, we have presented their influence on the properties of HA, as well as the latest applications of doped materials in the biomedical field. |
format | Online Article Text |
id | pubmed-10488011 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-104880112023-09-09 Latest Research of Doped Hydroxyapatite for Bone Tissue Engineering Radulescu, Diana-Elena Vasile, Otilia Ruxandra Andronescu, Ecaterina Ficai, Anton Int J Mol Sci Review Bone tissue engineering has attracted great interest in the last few years, as the frequency of tissue-damaging or degenerative diseases has increased exponentially. To obtain an ideal treatment solution, researchers have focused on the development of optimum biomaterials to be applied for the enhancement of bioactivity and the regeneration process, which are necessary to support the proper healing process of osseous tissues. In this regard, hydroxyapatite (HA) has been the most widely used material in the biomedical field due to its great biocompatibility and similarity with the native apatite from the human bone. However, HA still presents some deficiencies related to its mechanical properties, which are essential for HA to be applied in load-bearing applications. Bioactivity is another vital property of HA and is necessary to further improve regeneration and antibacterial activity. These drawbacks can be solved by doping the material with trace elements, adapting the properties of the material, and, finally, sustaining bone regeneration without the occurrence of implant failure. Considering these aspects, in this review, we have presented some general information about HA properties, synthesis methods, applications, and the necessity for the addition of doping ions into its structure. Also, we have presented their influence on the properties of HA, as well as the latest applications of doped materials in the biomedical field. MDPI 2023-08-24 /pmc/articles/PMC10488011/ /pubmed/37685968 http://dx.doi.org/10.3390/ijms241713157 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Radulescu, Diana-Elena Vasile, Otilia Ruxandra Andronescu, Ecaterina Ficai, Anton Latest Research of Doped Hydroxyapatite for Bone Tissue Engineering |
title | Latest Research of Doped Hydroxyapatite for Bone Tissue Engineering |
title_full | Latest Research of Doped Hydroxyapatite for Bone Tissue Engineering |
title_fullStr | Latest Research of Doped Hydroxyapatite for Bone Tissue Engineering |
title_full_unstemmed | Latest Research of Doped Hydroxyapatite for Bone Tissue Engineering |
title_short | Latest Research of Doped Hydroxyapatite for Bone Tissue Engineering |
title_sort | latest research of doped hydroxyapatite for bone tissue engineering |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10488011/ https://www.ncbi.nlm.nih.gov/pubmed/37685968 http://dx.doi.org/10.3390/ijms241713157 |
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