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Latest Research of Doped Hydroxyapatite for Bone Tissue Engineering

Bone tissue engineering has attracted great interest in the last few years, as the frequency of tissue-damaging or degenerative diseases has increased exponentially. To obtain an ideal treatment solution, researchers have focused on the development of optimum biomaterials to be applied for the enhan...

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Autores principales: Radulescu, Diana-Elena, Vasile, Otilia Ruxandra, Andronescu, Ecaterina, Ficai, Anton
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10488011/
https://www.ncbi.nlm.nih.gov/pubmed/37685968
http://dx.doi.org/10.3390/ijms241713157
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author Radulescu, Diana-Elena
Vasile, Otilia Ruxandra
Andronescu, Ecaterina
Ficai, Anton
author_facet Radulescu, Diana-Elena
Vasile, Otilia Ruxandra
Andronescu, Ecaterina
Ficai, Anton
author_sort Radulescu, Diana-Elena
collection PubMed
description Bone tissue engineering has attracted great interest in the last few years, as the frequency of tissue-damaging or degenerative diseases has increased exponentially. To obtain an ideal treatment solution, researchers have focused on the development of optimum biomaterials to be applied for the enhancement of bioactivity and the regeneration process, which are necessary to support the proper healing process of osseous tissues. In this regard, hydroxyapatite (HA) has been the most widely used material in the biomedical field due to its great biocompatibility and similarity with the native apatite from the human bone. However, HA still presents some deficiencies related to its mechanical properties, which are essential for HA to be applied in load-bearing applications. Bioactivity is another vital property of HA and is necessary to further improve regeneration and antibacterial activity. These drawbacks can be solved by doping the material with trace elements, adapting the properties of the material, and, finally, sustaining bone regeneration without the occurrence of implant failure. Considering these aspects, in this review, we have presented some general information about HA properties, synthesis methods, applications, and the necessity for the addition of doping ions into its structure. Also, we have presented their influence on the properties of HA, as well as the latest applications of doped materials in the biomedical field.
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spelling pubmed-104880112023-09-09 Latest Research of Doped Hydroxyapatite for Bone Tissue Engineering Radulescu, Diana-Elena Vasile, Otilia Ruxandra Andronescu, Ecaterina Ficai, Anton Int J Mol Sci Review Bone tissue engineering has attracted great interest in the last few years, as the frequency of tissue-damaging or degenerative diseases has increased exponentially. To obtain an ideal treatment solution, researchers have focused on the development of optimum biomaterials to be applied for the enhancement of bioactivity and the regeneration process, which are necessary to support the proper healing process of osseous tissues. In this regard, hydroxyapatite (HA) has been the most widely used material in the biomedical field due to its great biocompatibility and similarity with the native apatite from the human bone. However, HA still presents some deficiencies related to its mechanical properties, which are essential for HA to be applied in load-bearing applications. Bioactivity is another vital property of HA and is necessary to further improve regeneration and antibacterial activity. These drawbacks can be solved by doping the material with trace elements, adapting the properties of the material, and, finally, sustaining bone regeneration without the occurrence of implant failure. Considering these aspects, in this review, we have presented some general information about HA properties, synthesis methods, applications, and the necessity for the addition of doping ions into its structure. Also, we have presented their influence on the properties of HA, as well as the latest applications of doped materials in the biomedical field. MDPI 2023-08-24 /pmc/articles/PMC10488011/ /pubmed/37685968 http://dx.doi.org/10.3390/ijms241713157 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Radulescu, Diana-Elena
Vasile, Otilia Ruxandra
Andronescu, Ecaterina
Ficai, Anton
Latest Research of Doped Hydroxyapatite for Bone Tissue Engineering
title Latest Research of Doped Hydroxyapatite for Bone Tissue Engineering
title_full Latest Research of Doped Hydroxyapatite for Bone Tissue Engineering
title_fullStr Latest Research of Doped Hydroxyapatite for Bone Tissue Engineering
title_full_unstemmed Latest Research of Doped Hydroxyapatite for Bone Tissue Engineering
title_short Latest Research of Doped Hydroxyapatite for Bone Tissue Engineering
title_sort latest research of doped hydroxyapatite for bone tissue engineering
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10488011/
https://www.ncbi.nlm.nih.gov/pubmed/37685968
http://dx.doi.org/10.3390/ijms241713157
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