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Are Antimicrobial Peptides a 21st-Century Solution for Atopic Dermatitis?
Atopic dermatitis (AD) is a chronic inflammatory skin disorder that is the result of various environmental, bacterial and genetic stimuli, which culminate in the disruption of the skin’s barrier function. Characterized by highly pruritic skin lesions, xerosis and an array of comorbidities among whic...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10488019/ https://www.ncbi.nlm.nih.gov/pubmed/37686269 http://dx.doi.org/10.3390/ijms241713460 |
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author | Machado, Manuela Silva, Sara Costa, Eduardo M. |
author_facet | Machado, Manuela Silva, Sara Costa, Eduardo M. |
author_sort | Machado, Manuela |
collection | PubMed |
description | Atopic dermatitis (AD) is a chronic inflammatory skin disorder that is the result of various environmental, bacterial and genetic stimuli, which culminate in the disruption of the skin’s barrier function. Characterized by highly pruritic skin lesions, xerosis and an array of comorbidities among which skin infections are the most common, this condition results in both a significant loss of quality of life and in the need for life-long treatments (e.g., corticosteroids, monoclonal antibodies and regular antibiotic intake), all of which may have harmful secondary effects. This, in conjunction with AD’s rising prevalence, made the development of alternative treatment strategies the focus of both the scientific community and the pharmaceutical industry. Given their potential to both manage the skin microbiome, fight infections and even modulate the local immune response, the use of antimicrobial peptides (AMPs) from more diverse origins has become one of the most promising alternative solutions for AD management, with some being already used with some success towards this end. However, their production and use also exhibit some limitations. The current work seeks to compile the available information and provide a better understanding of the state of the art in the understanding of AMPs’ true potential in addressing AD. |
format | Online Article Text |
id | pubmed-10488019 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-104880192023-09-09 Are Antimicrobial Peptides a 21st-Century Solution for Atopic Dermatitis? Machado, Manuela Silva, Sara Costa, Eduardo M. Int J Mol Sci Review Atopic dermatitis (AD) is a chronic inflammatory skin disorder that is the result of various environmental, bacterial and genetic stimuli, which culminate in the disruption of the skin’s barrier function. Characterized by highly pruritic skin lesions, xerosis and an array of comorbidities among which skin infections are the most common, this condition results in both a significant loss of quality of life and in the need for life-long treatments (e.g., corticosteroids, monoclonal antibodies and regular antibiotic intake), all of which may have harmful secondary effects. This, in conjunction with AD’s rising prevalence, made the development of alternative treatment strategies the focus of both the scientific community and the pharmaceutical industry. Given their potential to both manage the skin microbiome, fight infections and even modulate the local immune response, the use of antimicrobial peptides (AMPs) from more diverse origins has become one of the most promising alternative solutions for AD management, with some being already used with some success towards this end. However, their production and use also exhibit some limitations. The current work seeks to compile the available information and provide a better understanding of the state of the art in the understanding of AMPs’ true potential in addressing AD. MDPI 2023-08-30 /pmc/articles/PMC10488019/ /pubmed/37686269 http://dx.doi.org/10.3390/ijms241713460 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Machado, Manuela Silva, Sara Costa, Eduardo M. Are Antimicrobial Peptides a 21st-Century Solution for Atopic Dermatitis? |
title | Are Antimicrobial Peptides a 21st-Century Solution for Atopic Dermatitis? |
title_full | Are Antimicrobial Peptides a 21st-Century Solution for Atopic Dermatitis? |
title_fullStr | Are Antimicrobial Peptides a 21st-Century Solution for Atopic Dermatitis? |
title_full_unstemmed | Are Antimicrobial Peptides a 21st-Century Solution for Atopic Dermatitis? |
title_short | Are Antimicrobial Peptides a 21st-Century Solution for Atopic Dermatitis? |
title_sort | are antimicrobial peptides a 21st-century solution for atopic dermatitis? |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10488019/ https://www.ncbi.nlm.nih.gov/pubmed/37686269 http://dx.doi.org/10.3390/ijms241713460 |
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