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Hypertrophic Cardiomyopathy versus Storage Diseases with Myocardial Involvement

One of the main causes of heart failure is cardiomyopathies. Among them, the most common is hypertrophic cardiomyopathy (HCM), characterized by thickening of the left ventricular muscle. This article focuses on HCM and other cardiomyopathies with myocardial hypertrophy, including Fabry disease, Pomp...

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Autores principales: Burban, Anna, Pucyło, Szymon, Sikora, Aleksandra, Opolski, Grzegorz, Grabowski, Marcin, Kołodzińska, Agnieszka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10488064/
https://www.ncbi.nlm.nih.gov/pubmed/37686045
http://dx.doi.org/10.3390/ijms241713239
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author Burban, Anna
Pucyło, Szymon
Sikora, Aleksandra
Opolski, Grzegorz
Grabowski, Marcin
Kołodzińska, Agnieszka
author_facet Burban, Anna
Pucyło, Szymon
Sikora, Aleksandra
Opolski, Grzegorz
Grabowski, Marcin
Kołodzińska, Agnieszka
author_sort Burban, Anna
collection PubMed
description One of the main causes of heart failure is cardiomyopathies. Among them, the most common is hypertrophic cardiomyopathy (HCM), characterized by thickening of the left ventricular muscle. This article focuses on HCM and other cardiomyopathies with myocardial hypertrophy, including Fabry disease, Pompe disease, and Danon disease. The genetics and pathogenesis of these diseases are described, as well as current and experimental treatment options, such as pharmacological intervention and the potential of gene therapies. Although genetic approaches are promising and have the potential to become the best treatments for these diseases, further research is needed to evaluate their efficacy and safety. This article describes current knowledge and advances in the treatment of the aforementioned cardiomyopathies.
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spelling pubmed-104880642023-09-09 Hypertrophic Cardiomyopathy versus Storage Diseases with Myocardial Involvement Burban, Anna Pucyło, Szymon Sikora, Aleksandra Opolski, Grzegorz Grabowski, Marcin Kołodzińska, Agnieszka Int J Mol Sci Review One of the main causes of heart failure is cardiomyopathies. Among them, the most common is hypertrophic cardiomyopathy (HCM), characterized by thickening of the left ventricular muscle. This article focuses on HCM and other cardiomyopathies with myocardial hypertrophy, including Fabry disease, Pompe disease, and Danon disease. The genetics and pathogenesis of these diseases are described, as well as current and experimental treatment options, such as pharmacological intervention and the potential of gene therapies. Although genetic approaches are promising and have the potential to become the best treatments for these diseases, further research is needed to evaluate their efficacy and safety. This article describes current knowledge and advances in the treatment of the aforementioned cardiomyopathies. MDPI 2023-08-26 /pmc/articles/PMC10488064/ /pubmed/37686045 http://dx.doi.org/10.3390/ijms241713239 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Burban, Anna
Pucyło, Szymon
Sikora, Aleksandra
Opolski, Grzegorz
Grabowski, Marcin
Kołodzińska, Agnieszka
Hypertrophic Cardiomyopathy versus Storage Diseases with Myocardial Involvement
title Hypertrophic Cardiomyopathy versus Storage Diseases with Myocardial Involvement
title_full Hypertrophic Cardiomyopathy versus Storage Diseases with Myocardial Involvement
title_fullStr Hypertrophic Cardiomyopathy versus Storage Diseases with Myocardial Involvement
title_full_unstemmed Hypertrophic Cardiomyopathy versus Storage Diseases with Myocardial Involvement
title_short Hypertrophic Cardiomyopathy versus Storage Diseases with Myocardial Involvement
title_sort hypertrophic cardiomyopathy versus storage diseases with myocardial involvement
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10488064/
https://www.ncbi.nlm.nih.gov/pubmed/37686045
http://dx.doi.org/10.3390/ijms241713239
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