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Hypertrophic Cardiomyopathy versus Storage Diseases with Myocardial Involvement
One of the main causes of heart failure is cardiomyopathies. Among them, the most common is hypertrophic cardiomyopathy (HCM), characterized by thickening of the left ventricular muscle. This article focuses on HCM and other cardiomyopathies with myocardial hypertrophy, including Fabry disease, Pomp...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10488064/ https://www.ncbi.nlm.nih.gov/pubmed/37686045 http://dx.doi.org/10.3390/ijms241713239 |
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author | Burban, Anna Pucyło, Szymon Sikora, Aleksandra Opolski, Grzegorz Grabowski, Marcin Kołodzińska, Agnieszka |
author_facet | Burban, Anna Pucyło, Szymon Sikora, Aleksandra Opolski, Grzegorz Grabowski, Marcin Kołodzińska, Agnieszka |
author_sort | Burban, Anna |
collection | PubMed |
description | One of the main causes of heart failure is cardiomyopathies. Among them, the most common is hypertrophic cardiomyopathy (HCM), characterized by thickening of the left ventricular muscle. This article focuses on HCM and other cardiomyopathies with myocardial hypertrophy, including Fabry disease, Pompe disease, and Danon disease. The genetics and pathogenesis of these diseases are described, as well as current and experimental treatment options, such as pharmacological intervention and the potential of gene therapies. Although genetic approaches are promising and have the potential to become the best treatments for these diseases, further research is needed to evaluate their efficacy and safety. This article describes current knowledge and advances in the treatment of the aforementioned cardiomyopathies. |
format | Online Article Text |
id | pubmed-10488064 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-104880642023-09-09 Hypertrophic Cardiomyopathy versus Storage Diseases with Myocardial Involvement Burban, Anna Pucyło, Szymon Sikora, Aleksandra Opolski, Grzegorz Grabowski, Marcin Kołodzińska, Agnieszka Int J Mol Sci Review One of the main causes of heart failure is cardiomyopathies. Among them, the most common is hypertrophic cardiomyopathy (HCM), characterized by thickening of the left ventricular muscle. This article focuses on HCM and other cardiomyopathies with myocardial hypertrophy, including Fabry disease, Pompe disease, and Danon disease. The genetics and pathogenesis of these diseases are described, as well as current and experimental treatment options, such as pharmacological intervention and the potential of gene therapies. Although genetic approaches are promising and have the potential to become the best treatments for these diseases, further research is needed to evaluate their efficacy and safety. This article describes current knowledge and advances in the treatment of the aforementioned cardiomyopathies. MDPI 2023-08-26 /pmc/articles/PMC10488064/ /pubmed/37686045 http://dx.doi.org/10.3390/ijms241713239 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Burban, Anna Pucyło, Szymon Sikora, Aleksandra Opolski, Grzegorz Grabowski, Marcin Kołodzińska, Agnieszka Hypertrophic Cardiomyopathy versus Storage Diseases with Myocardial Involvement |
title | Hypertrophic Cardiomyopathy versus Storage Diseases with Myocardial Involvement |
title_full | Hypertrophic Cardiomyopathy versus Storage Diseases with Myocardial Involvement |
title_fullStr | Hypertrophic Cardiomyopathy versus Storage Diseases with Myocardial Involvement |
title_full_unstemmed | Hypertrophic Cardiomyopathy versus Storage Diseases with Myocardial Involvement |
title_short | Hypertrophic Cardiomyopathy versus Storage Diseases with Myocardial Involvement |
title_sort | hypertrophic cardiomyopathy versus storage diseases with myocardial involvement |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10488064/ https://www.ncbi.nlm.nih.gov/pubmed/37686045 http://dx.doi.org/10.3390/ijms241713239 |
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