The sGC Activator Runcaciguat Has Kidney Protective Effects and Prevents a Decline of Kidney Function in ZSF1 Rats

Chronic kidney disease (CKD) progression is associated with persisting oxidative stress, which impairs the NO-sGC-cGMP signaling cascade through the formation of oxidized and heme-free apo-sGC that cannot be activated by NO. Runcaciguat (BAY 1101042) is a novel, potent, and selective sGC activator t...

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Detalles Bibliográficos
Autores principales: Kraehling, Jan R., Benardeau, Agnes, Schomber, Tibor, Popp, Laura, Vienenkoetter, Julia, Ellinger-Ziegelbauer, Heidrun, Pavkovic, Mira, Hartmann, Elke, Siudak, Krystyna, Freyberger, Alexius, Hagelschuer, Ina, Mathar, Ilka, Hueser, Joerg, Hahn, Michael G., Geiss, Volker, Eitner, Frank, Sandner, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10488129/
https://www.ncbi.nlm.nih.gov/pubmed/37686032
http://dx.doi.org/10.3390/ijms241713226

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