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Transferrin-Targeted Liposomes in Glioblastoma Therapy: A Review

Glioblastoma (GBM) is a highly aggressive brain tumor, and its treatment is further complicated by the high selectivity of the blood–brain barrier (BBB). The scientific community is urgently seeking innovative and effective therapeutic solutions. Liposomes are a promising new tool that has shown pot...

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Autores principales: Kawak, Paul, Sawaftah, Nour M. Al, Pitt, William G., Husseini, Ghaleb A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10488197/
https://www.ncbi.nlm.nih.gov/pubmed/37686065
http://dx.doi.org/10.3390/ijms241713262
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author Kawak, Paul
Sawaftah, Nour M. Al
Pitt, William G.
Husseini, Ghaleb A.
author_facet Kawak, Paul
Sawaftah, Nour M. Al
Pitt, William G.
Husseini, Ghaleb A.
author_sort Kawak, Paul
collection PubMed
description Glioblastoma (GBM) is a highly aggressive brain tumor, and its treatment is further complicated by the high selectivity of the blood–brain barrier (BBB). The scientific community is urgently seeking innovative and effective therapeutic solutions. Liposomes are a promising new tool that has shown potential in addressing the limitations of chemotherapy, such as poor bioavailability and toxicity to healthy cells. However, passive targeting strategies based solely on the physicochemical properties of liposomes have proven ineffective due to a lack of tissue specificity. Accordingly, the upregulation of transferrin receptors (TfRs) in brain tissue has led to the development of TfR-targeted anticancer therapeutics. Currently, one of the most widely adopted methods for improving drug delivery in the treatment of GBM and other neurological disorders is the utilization of active targeting strategies that specifically target this receptor. In this review, we discuss the role of Tf-conjugated liposomes in GBM therapy and present some recent studies investigating the drug delivery efficiency of Tf-liposomes; in addition, we address some challenges currently facing this approach to treatment and present some potential improvement possibilities.
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spelling pubmed-104881972023-09-09 Transferrin-Targeted Liposomes in Glioblastoma Therapy: A Review Kawak, Paul Sawaftah, Nour M. Al Pitt, William G. Husseini, Ghaleb A. Int J Mol Sci Review Glioblastoma (GBM) is a highly aggressive brain tumor, and its treatment is further complicated by the high selectivity of the blood–brain barrier (BBB). The scientific community is urgently seeking innovative and effective therapeutic solutions. Liposomes are a promising new tool that has shown potential in addressing the limitations of chemotherapy, such as poor bioavailability and toxicity to healthy cells. However, passive targeting strategies based solely on the physicochemical properties of liposomes have proven ineffective due to a lack of tissue specificity. Accordingly, the upregulation of transferrin receptors (TfRs) in brain tissue has led to the development of TfR-targeted anticancer therapeutics. Currently, one of the most widely adopted methods for improving drug delivery in the treatment of GBM and other neurological disorders is the utilization of active targeting strategies that specifically target this receptor. In this review, we discuss the role of Tf-conjugated liposomes in GBM therapy and present some recent studies investigating the drug delivery efficiency of Tf-liposomes; in addition, we address some challenges currently facing this approach to treatment and present some potential improvement possibilities. MDPI 2023-08-26 /pmc/articles/PMC10488197/ /pubmed/37686065 http://dx.doi.org/10.3390/ijms241713262 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kawak, Paul
Sawaftah, Nour M. Al
Pitt, William G.
Husseini, Ghaleb A.
Transferrin-Targeted Liposomes in Glioblastoma Therapy: A Review
title Transferrin-Targeted Liposomes in Glioblastoma Therapy: A Review
title_full Transferrin-Targeted Liposomes in Glioblastoma Therapy: A Review
title_fullStr Transferrin-Targeted Liposomes in Glioblastoma Therapy: A Review
title_full_unstemmed Transferrin-Targeted Liposomes in Glioblastoma Therapy: A Review
title_short Transferrin-Targeted Liposomes in Glioblastoma Therapy: A Review
title_sort transferrin-targeted liposomes in glioblastoma therapy: a review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10488197/
https://www.ncbi.nlm.nih.gov/pubmed/37686065
http://dx.doi.org/10.3390/ijms241713262
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