Cargando…

Gasdermin D (GSDMD) Is Upregulated in Psoriatic Skin—A New Potential Link in the Pathogenesis of Psoriasis

Psoriasis is an important issue in daily dermatological practice. Not only is it an aesthetic defect but it is also a matter of decreased life quality and economic burden. However frequent, the pathogenesis of psoriasis remains uncertain despite numerous investigations. Gasdermins are a family of si...

Descripción completa

Detalles Bibliográficos
Autores principales: Nowowiejska, Julia, Baran, Anna, Hermanowicz, Justyna Magdalena, Pryczynicz, Anna, Sieklucka, Beata, Pawlak, Dariusz, Flisiak, Iwona
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10488204/
https://www.ncbi.nlm.nih.gov/pubmed/37685853
http://dx.doi.org/10.3390/ijms241713047
_version_ 1785103423593512960
author Nowowiejska, Julia
Baran, Anna
Hermanowicz, Justyna Magdalena
Pryczynicz, Anna
Sieklucka, Beata
Pawlak, Dariusz
Flisiak, Iwona
author_facet Nowowiejska, Julia
Baran, Anna
Hermanowicz, Justyna Magdalena
Pryczynicz, Anna
Sieklucka, Beata
Pawlak, Dariusz
Flisiak, Iwona
author_sort Nowowiejska, Julia
collection PubMed
description Psoriasis is an important issue in daily dermatological practice. Not only is it an aesthetic defect but it is also a matter of decreased life quality and economic burden. However frequent, the pathogenesis of psoriasis remains uncertain despite numerous investigations. Gasdermins are a family of six proteins. Gasdermin D (GSDMD) is the best-studied from this group and is involved in the processes of inflammation, proliferation, and death of cells, especially pyroptosis. GSDMD has never been studied in psoriatic sera or urine before. Our study involved 60 patients with psoriasis and 30 volunteers without dermatoses as controls. Serum and urinary GSDMD concentrations were examined by ELISA. The tissue expression of GSDMD was assessed by immunohistochemistry. The serum-GSDMD concentration was insignificantly higher in the patients than controls. There were no differences in the urinary-GSDMD concentrations between the patients and controls. Strong tissue expression of GSDMD was significantly more prevalent in psoriatic plaque than in the non-lesional skin and healthy skin of the controls. There was no correlation between the serum-GSDMD concentrations and the psoriasis severity in PASI, age, or disease duration. Taking into consideration the documented role of gasdermins in cell proliferation and death, the increased expression of GSDMD in psoriatic skin may demonstrate the potential involvement of this protein in psoriasis pathogenesis. Neither serum, nor urinary GSDMD can be currently considered a psoriasis biomarker; however, future studies may change this perspective.
format Online
Article
Text
id pubmed-10488204
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-104882042023-09-09 Gasdermin D (GSDMD) Is Upregulated in Psoriatic Skin—A New Potential Link in the Pathogenesis of Psoriasis Nowowiejska, Julia Baran, Anna Hermanowicz, Justyna Magdalena Pryczynicz, Anna Sieklucka, Beata Pawlak, Dariusz Flisiak, Iwona Int J Mol Sci Article Psoriasis is an important issue in daily dermatological practice. Not only is it an aesthetic defect but it is also a matter of decreased life quality and economic burden. However frequent, the pathogenesis of psoriasis remains uncertain despite numerous investigations. Gasdermins are a family of six proteins. Gasdermin D (GSDMD) is the best-studied from this group and is involved in the processes of inflammation, proliferation, and death of cells, especially pyroptosis. GSDMD has never been studied in psoriatic sera or urine before. Our study involved 60 patients with psoriasis and 30 volunteers without dermatoses as controls. Serum and urinary GSDMD concentrations were examined by ELISA. The tissue expression of GSDMD was assessed by immunohistochemistry. The serum-GSDMD concentration was insignificantly higher in the patients than controls. There were no differences in the urinary-GSDMD concentrations between the patients and controls. Strong tissue expression of GSDMD was significantly more prevalent in psoriatic plaque than in the non-lesional skin and healthy skin of the controls. There was no correlation between the serum-GSDMD concentrations and the psoriasis severity in PASI, age, or disease duration. Taking into consideration the documented role of gasdermins in cell proliferation and death, the increased expression of GSDMD in psoriatic skin may demonstrate the potential involvement of this protein in psoriasis pathogenesis. Neither serum, nor urinary GSDMD can be currently considered a psoriasis biomarker; however, future studies may change this perspective. MDPI 2023-08-22 /pmc/articles/PMC10488204/ /pubmed/37685853 http://dx.doi.org/10.3390/ijms241713047 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Nowowiejska, Julia
Baran, Anna
Hermanowicz, Justyna Magdalena
Pryczynicz, Anna
Sieklucka, Beata
Pawlak, Dariusz
Flisiak, Iwona
Gasdermin D (GSDMD) Is Upregulated in Psoriatic Skin—A New Potential Link in the Pathogenesis of Psoriasis
title Gasdermin D (GSDMD) Is Upregulated in Psoriatic Skin—A New Potential Link in the Pathogenesis of Psoriasis
title_full Gasdermin D (GSDMD) Is Upregulated in Psoriatic Skin—A New Potential Link in the Pathogenesis of Psoriasis
title_fullStr Gasdermin D (GSDMD) Is Upregulated in Psoriatic Skin—A New Potential Link in the Pathogenesis of Psoriasis
title_full_unstemmed Gasdermin D (GSDMD) Is Upregulated in Psoriatic Skin—A New Potential Link in the Pathogenesis of Psoriasis
title_short Gasdermin D (GSDMD) Is Upregulated in Psoriatic Skin—A New Potential Link in the Pathogenesis of Psoriasis
title_sort gasdermin d (gsdmd) is upregulated in psoriatic skin—a new potential link in the pathogenesis of psoriasis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10488204/
https://www.ncbi.nlm.nih.gov/pubmed/37685853
http://dx.doi.org/10.3390/ijms241713047
work_keys_str_mv AT nowowiejskajulia gasdermindgsdmdisupregulatedinpsoriaticskinanewpotentiallinkinthepathogenesisofpsoriasis
AT barananna gasdermindgsdmdisupregulatedinpsoriaticskinanewpotentiallinkinthepathogenesisofpsoriasis
AT hermanowiczjustynamagdalena gasdermindgsdmdisupregulatedinpsoriaticskinanewpotentiallinkinthepathogenesisofpsoriasis
AT pryczyniczanna gasdermindgsdmdisupregulatedinpsoriaticskinanewpotentiallinkinthepathogenesisofpsoriasis
AT siekluckabeata gasdermindgsdmdisupregulatedinpsoriaticskinanewpotentiallinkinthepathogenesisofpsoriasis
AT pawlakdariusz gasdermindgsdmdisupregulatedinpsoriaticskinanewpotentiallinkinthepathogenesisofpsoriasis
AT flisiakiwona gasdermindgsdmdisupregulatedinpsoriaticskinanewpotentiallinkinthepathogenesisofpsoriasis