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COVID-19 Vaccination and Disease Course in People with Multiple Sclerosis in Greece

Over the past three years, humanity faced the abrupt spread of COVID-19, responsible for a worldwide health crisis. Initially, it was believed that individuals with chronic disorders, including multiple sclerosis, were more likely to be infected and suffer a worse degree of COVID-19 disease. Therefo...

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Autores principales: Bakirtzis, Christos, Konstantinidou, Natalia, Stavropoulou De Lorenzo, Sotiria, Moysiadis, Theodoros, Boziki, Marina-Kleopatra, Grigoriadou, Eleni, Kesidou, Evangelia, Theotokis, Paschalis, Thireos, Eleftherios, Mitrou, Panagiota, Grigoriadis, Nikolaos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10488265/
https://www.ncbi.nlm.nih.gov/pubmed/37685528
http://dx.doi.org/10.3390/jcm12175460
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author Bakirtzis, Christos
Konstantinidou, Natalia
Stavropoulou De Lorenzo, Sotiria
Moysiadis, Theodoros
Boziki, Marina-Kleopatra
Grigoriadou, Eleni
Kesidou, Evangelia
Theotokis, Paschalis
Thireos, Eleftherios
Mitrou, Panagiota
Grigoriadis, Nikolaos
author_facet Bakirtzis, Christos
Konstantinidou, Natalia
Stavropoulou De Lorenzo, Sotiria
Moysiadis, Theodoros
Boziki, Marina-Kleopatra
Grigoriadou, Eleni
Kesidou, Evangelia
Theotokis, Paschalis
Thireos, Eleftherios
Mitrou, Panagiota
Grigoriadis, Nikolaos
author_sort Bakirtzis, Christos
collection PubMed
description Over the past three years, humanity faced the abrupt spread of COVID-19, responsible for a worldwide health crisis. Initially, it was believed that individuals with chronic disorders, including multiple sclerosis, were more likely to be infected and suffer a worse degree of COVID-19 disease. Therefore, data with regard to COVID-19 disease outcomes in these populations may provide additional insight with regard to the management of chronic diseases during viral pandemics. The objective of this study is to evaluate COVID-19 disease course in people with multiple sclerosis (PwMS) during the COVID-19 pandemic in Greece and explore the impact of vaccination in the outcome of SARS-CoV-2 infection in this population. Anonymized data, extracted from nationwide administrative records between February 2020 and December 2021, were retrospectively analyzed in order to identify PwMS with SARS-CoV-2 infection. Demographic data, as well as data regarding COVID-19 infection and vaccination, were additionally collected. The study sample included 2351 PwMS (65.1% females, 51.2% unvaccinated at the time of infection). A total of 260 PwMS were hospitalized, while 25 PwMS died from COVID-19 disease and its complications. Older age, male sex and the presence of comorbidities were independently associated with a higher probability of hospitalization. The risk of hospitalization was decreased in PwMS receiving some disease-modifying treatments. Anti-CD20s demonstrated high odds ratios without reaching statistical significance. Regarding fatal outcome, only age reached statistical significance. Vaccination provided a significant protective effect against hospitalization but did not exhibit a statistically significant effect on mortality.
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spelling pubmed-104882652023-09-09 COVID-19 Vaccination and Disease Course in People with Multiple Sclerosis in Greece Bakirtzis, Christos Konstantinidou, Natalia Stavropoulou De Lorenzo, Sotiria Moysiadis, Theodoros Boziki, Marina-Kleopatra Grigoriadou, Eleni Kesidou, Evangelia Theotokis, Paschalis Thireos, Eleftherios Mitrou, Panagiota Grigoriadis, Nikolaos J Clin Med Article Over the past three years, humanity faced the abrupt spread of COVID-19, responsible for a worldwide health crisis. Initially, it was believed that individuals with chronic disorders, including multiple sclerosis, were more likely to be infected and suffer a worse degree of COVID-19 disease. Therefore, data with regard to COVID-19 disease outcomes in these populations may provide additional insight with regard to the management of chronic diseases during viral pandemics. The objective of this study is to evaluate COVID-19 disease course in people with multiple sclerosis (PwMS) during the COVID-19 pandemic in Greece and explore the impact of vaccination in the outcome of SARS-CoV-2 infection in this population. Anonymized data, extracted from nationwide administrative records between February 2020 and December 2021, were retrospectively analyzed in order to identify PwMS with SARS-CoV-2 infection. Demographic data, as well as data regarding COVID-19 infection and vaccination, were additionally collected. The study sample included 2351 PwMS (65.1% females, 51.2% unvaccinated at the time of infection). A total of 260 PwMS were hospitalized, while 25 PwMS died from COVID-19 disease and its complications. Older age, male sex and the presence of comorbidities were independently associated with a higher probability of hospitalization. The risk of hospitalization was decreased in PwMS receiving some disease-modifying treatments. Anti-CD20s demonstrated high odds ratios without reaching statistical significance. Regarding fatal outcome, only age reached statistical significance. Vaccination provided a significant protective effect against hospitalization but did not exhibit a statistically significant effect on mortality. MDPI 2023-08-23 /pmc/articles/PMC10488265/ /pubmed/37685528 http://dx.doi.org/10.3390/jcm12175460 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Bakirtzis, Christos
Konstantinidou, Natalia
Stavropoulou De Lorenzo, Sotiria
Moysiadis, Theodoros
Boziki, Marina-Kleopatra
Grigoriadou, Eleni
Kesidou, Evangelia
Theotokis, Paschalis
Thireos, Eleftherios
Mitrou, Panagiota
Grigoriadis, Nikolaos
COVID-19 Vaccination and Disease Course in People with Multiple Sclerosis in Greece
title COVID-19 Vaccination and Disease Course in People with Multiple Sclerosis in Greece
title_full COVID-19 Vaccination and Disease Course in People with Multiple Sclerosis in Greece
title_fullStr COVID-19 Vaccination and Disease Course in People with Multiple Sclerosis in Greece
title_full_unstemmed COVID-19 Vaccination and Disease Course in People with Multiple Sclerosis in Greece
title_short COVID-19 Vaccination and Disease Course in People with Multiple Sclerosis in Greece
title_sort covid-19 vaccination and disease course in people with multiple sclerosis in greece
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10488265/
https://www.ncbi.nlm.nih.gov/pubmed/37685528
http://dx.doi.org/10.3390/jcm12175460
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