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COVID-19 Vaccination and Disease Course in People with Multiple Sclerosis in Greece
Over the past three years, humanity faced the abrupt spread of COVID-19, responsible for a worldwide health crisis. Initially, it was believed that individuals with chronic disorders, including multiple sclerosis, were more likely to be infected and suffer a worse degree of COVID-19 disease. Therefo...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10488265/ https://www.ncbi.nlm.nih.gov/pubmed/37685528 http://dx.doi.org/10.3390/jcm12175460 |
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author | Bakirtzis, Christos Konstantinidou, Natalia Stavropoulou De Lorenzo, Sotiria Moysiadis, Theodoros Boziki, Marina-Kleopatra Grigoriadou, Eleni Kesidou, Evangelia Theotokis, Paschalis Thireos, Eleftherios Mitrou, Panagiota Grigoriadis, Nikolaos |
author_facet | Bakirtzis, Christos Konstantinidou, Natalia Stavropoulou De Lorenzo, Sotiria Moysiadis, Theodoros Boziki, Marina-Kleopatra Grigoriadou, Eleni Kesidou, Evangelia Theotokis, Paschalis Thireos, Eleftherios Mitrou, Panagiota Grigoriadis, Nikolaos |
author_sort | Bakirtzis, Christos |
collection | PubMed |
description | Over the past three years, humanity faced the abrupt spread of COVID-19, responsible for a worldwide health crisis. Initially, it was believed that individuals with chronic disorders, including multiple sclerosis, were more likely to be infected and suffer a worse degree of COVID-19 disease. Therefore, data with regard to COVID-19 disease outcomes in these populations may provide additional insight with regard to the management of chronic diseases during viral pandemics. The objective of this study is to evaluate COVID-19 disease course in people with multiple sclerosis (PwMS) during the COVID-19 pandemic in Greece and explore the impact of vaccination in the outcome of SARS-CoV-2 infection in this population. Anonymized data, extracted from nationwide administrative records between February 2020 and December 2021, were retrospectively analyzed in order to identify PwMS with SARS-CoV-2 infection. Demographic data, as well as data regarding COVID-19 infection and vaccination, were additionally collected. The study sample included 2351 PwMS (65.1% females, 51.2% unvaccinated at the time of infection). A total of 260 PwMS were hospitalized, while 25 PwMS died from COVID-19 disease and its complications. Older age, male sex and the presence of comorbidities were independently associated with a higher probability of hospitalization. The risk of hospitalization was decreased in PwMS receiving some disease-modifying treatments. Anti-CD20s demonstrated high odds ratios without reaching statistical significance. Regarding fatal outcome, only age reached statistical significance. Vaccination provided a significant protective effect against hospitalization but did not exhibit a statistically significant effect on mortality. |
format | Online Article Text |
id | pubmed-10488265 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-104882652023-09-09 COVID-19 Vaccination and Disease Course in People with Multiple Sclerosis in Greece Bakirtzis, Christos Konstantinidou, Natalia Stavropoulou De Lorenzo, Sotiria Moysiadis, Theodoros Boziki, Marina-Kleopatra Grigoriadou, Eleni Kesidou, Evangelia Theotokis, Paschalis Thireos, Eleftherios Mitrou, Panagiota Grigoriadis, Nikolaos J Clin Med Article Over the past three years, humanity faced the abrupt spread of COVID-19, responsible for a worldwide health crisis. Initially, it was believed that individuals with chronic disorders, including multiple sclerosis, were more likely to be infected and suffer a worse degree of COVID-19 disease. Therefore, data with regard to COVID-19 disease outcomes in these populations may provide additional insight with regard to the management of chronic diseases during viral pandemics. The objective of this study is to evaluate COVID-19 disease course in people with multiple sclerosis (PwMS) during the COVID-19 pandemic in Greece and explore the impact of vaccination in the outcome of SARS-CoV-2 infection in this population. Anonymized data, extracted from nationwide administrative records between February 2020 and December 2021, were retrospectively analyzed in order to identify PwMS with SARS-CoV-2 infection. Demographic data, as well as data regarding COVID-19 infection and vaccination, were additionally collected. The study sample included 2351 PwMS (65.1% females, 51.2% unvaccinated at the time of infection). A total of 260 PwMS were hospitalized, while 25 PwMS died from COVID-19 disease and its complications. Older age, male sex and the presence of comorbidities were independently associated with a higher probability of hospitalization. The risk of hospitalization was decreased in PwMS receiving some disease-modifying treatments. Anti-CD20s demonstrated high odds ratios without reaching statistical significance. Regarding fatal outcome, only age reached statistical significance. Vaccination provided a significant protective effect against hospitalization but did not exhibit a statistically significant effect on mortality. MDPI 2023-08-23 /pmc/articles/PMC10488265/ /pubmed/37685528 http://dx.doi.org/10.3390/jcm12175460 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Bakirtzis, Christos Konstantinidou, Natalia Stavropoulou De Lorenzo, Sotiria Moysiadis, Theodoros Boziki, Marina-Kleopatra Grigoriadou, Eleni Kesidou, Evangelia Theotokis, Paschalis Thireos, Eleftherios Mitrou, Panagiota Grigoriadis, Nikolaos COVID-19 Vaccination and Disease Course in People with Multiple Sclerosis in Greece |
title | COVID-19 Vaccination and Disease Course in People with Multiple Sclerosis in Greece |
title_full | COVID-19 Vaccination and Disease Course in People with Multiple Sclerosis in Greece |
title_fullStr | COVID-19 Vaccination and Disease Course in People with Multiple Sclerosis in Greece |
title_full_unstemmed | COVID-19 Vaccination and Disease Course in People with Multiple Sclerosis in Greece |
title_short | COVID-19 Vaccination and Disease Course in People with Multiple Sclerosis in Greece |
title_sort | covid-19 vaccination and disease course in people with multiple sclerosis in greece |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10488265/ https://www.ncbi.nlm.nih.gov/pubmed/37685528 http://dx.doi.org/10.3390/jcm12175460 |
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