Cargando…

Immunohistochemical Expression of Upregulated Gene 4 Protein Expression (URG4/URGCP) and Its Association with 5-Year Survival in Patients with Colon Adenocarcinoma

(1) Background: Colorectal cancer (CRC) is the third most common cancer in terms of incidence and mortality. Approximately 90% of all colorectal cancer cases are adenocarcinomas, originating from epithelial cells of the colorectal mucosa. Upregulated gene 4 (URG4) is an oncogene involved in cancer d...

Descripción completa

Detalles Bibliográficos
Autores principales: Brzozowa-Zasada, Marlena, Piecuch, Adam, Michalski, Marek, Stęplewska, Katarzyna, Matysiak, Natalia, Kucharzewski, Marek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10488385/
https://www.ncbi.nlm.nih.gov/pubmed/37685545
http://dx.doi.org/10.3390/jcm12175477
_version_ 1785103462742097920
author Brzozowa-Zasada, Marlena
Piecuch, Adam
Michalski, Marek
Stęplewska, Katarzyna
Matysiak, Natalia
Kucharzewski, Marek
author_facet Brzozowa-Zasada, Marlena
Piecuch, Adam
Michalski, Marek
Stęplewska, Katarzyna
Matysiak, Natalia
Kucharzewski, Marek
author_sort Brzozowa-Zasada, Marlena
collection PubMed
description (1) Background: Colorectal cancer (CRC) is the third most common cancer in terms of incidence and mortality. Approximately 90% of all colorectal cancer cases are adenocarcinomas, originating from epithelial cells of the colorectal mucosa. Upregulated gene 4 (URG4) is an oncogene involved in cancer development. The aim of the study was to assess the immunohistochemical expression of URG4 protein expression in Polish patients with colon adenocarcinoma who were not treated with any therapy before radical surgery. (2) Methods: The study used colon tissue samples taken from people with a confirmed diagnosis of colorectal adenocarcinoma after a thorough histopathological examination. The associations between the immunohistochemical expression of URG4 and clinical parameters were analyzed by the Chi2 test or Chi2Yatesa test. The study conducted an analysis of the correlation between the expression of URG4 and the five-year survival rate of patients through the application of the Kaplan–Meier analysis and the log-rank statistical test. The intracellular localization of URG4 was identified through the utilization of transmission electron microscopy (TEM) methodology. (3) Results: In univariate Cox regression analyses, immuno-histochemical expression of URG4, grade of histological differentiation, depth of invasion, angioinvasion, PCNA expression, stage of disease and lymph node involvement were found to be significant prognostic factors. Within our patient cohort, it was observed that the degree of tumour differentiation and URG4 expression were found to be distinct prognostic factors in regard to the 5-year survival rates of those with colon adenocarcinoma. (4) Conclusions: High immunohistochemical expression of URG4 correlates with poor prognosis in patients with colon adenocarcinoma.
format Online
Article
Text
id pubmed-10488385
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-104883852023-09-09 Immunohistochemical Expression of Upregulated Gene 4 Protein Expression (URG4/URGCP) and Its Association with 5-Year Survival in Patients with Colon Adenocarcinoma Brzozowa-Zasada, Marlena Piecuch, Adam Michalski, Marek Stęplewska, Katarzyna Matysiak, Natalia Kucharzewski, Marek J Clin Med Article (1) Background: Colorectal cancer (CRC) is the third most common cancer in terms of incidence and mortality. Approximately 90% of all colorectal cancer cases are adenocarcinomas, originating from epithelial cells of the colorectal mucosa. Upregulated gene 4 (URG4) is an oncogene involved in cancer development. The aim of the study was to assess the immunohistochemical expression of URG4 protein expression in Polish patients with colon adenocarcinoma who were not treated with any therapy before radical surgery. (2) Methods: The study used colon tissue samples taken from people with a confirmed diagnosis of colorectal adenocarcinoma after a thorough histopathological examination. The associations between the immunohistochemical expression of URG4 and clinical parameters were analyzed by the Chi2 test or Chi2Yatesa test. The study conducted an analysis of the correlation between the expression of URG4 and the five-year survival rate of patients through the application of the Kaplan–Meier analysis and the log-rank statistical test. The intracellular localization of URG4 was identified through the utilization of transmission electron microscopy (TEM) methodology. (3) Results: In univariate Cox regression analyses, immuno-histochemical expression of URG4, grade of histological differentiation, depth of invasion, angioinvasion, PCNA expression, stage of disease and lymph node involvement were found to be significant prognostic factors. Within our patient cohort, it was observed that the degree of tumour differentiation and URG4 expression were found to be distinct prognostic factors in regard to the 5-year survival rates of those with colon adenocarcinoma. (4) Conclusions: High immunohistochemical expression of URG4 correlates with poor prognosis in patients with colon adenocarcinoma. MDPI 2023-08-23 /pmc/articles/PMC10488385/ /pubmed/37685545 http://dx.doi.org/10.3390/jcm12175477 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Brzozowa-Zasada, Marlena
Piecuch, Adam
Michalski, Marek
Stęplewska, Katarzyna
Matysiak, Natalia
Kucharzewski, Marek
Immunohistochemical Expression of Upregulated Gene 4 Protein Expression (URG4/URGCP) and Its Association with 5-Year Survival in Patients with Colon Adenocarcinoma
title Immunohistochemical Expression of Upregulated Gene 4 Protein Expression (URG4/URGCP) and Its Association with 5-Year Survival in Patients with Colon Adenocarcinoma
title_full Immunohistochemical Expression of Upregulated Gene 4 Protein Expression (URG4/URGCP) and Its Association with 5-Year Survival in Patients with Colon Adenocarcinoma
title_fullStr Immunohistochemical Expression of Upregulated Gene 4 Protein Expression (URG4/URGCP) and Its Association with 5-Year Survival in Patients with Colon Adenocarcinoma
title_full_unstemmed Immunohistochemical Expression of Upregulated Gene 4 Protein Expression (URG4/URGCP) and Its Association with 5-Year Survival in Patients with Colon Adenocarcinoma
title_short Immunohistochemical Expression of Upregulated Gene 4 Protein Expression (URG4/URGCP) and Its Association with 5-Year Survival in Patients with Colon Adenocarcinoma
title_sort immunohistochemical expression of upregulated gene 4 protein expression (urg4/urgcp) and its association with 5-year survival in patients with colon adenocarcinoma
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10488385/
https://www.ncbi.nlm.nih.gov/pubmed/37685545
http://dx.doi.org/10.3390/jcm12175477
work_keys_str_mv AT brzozowazasadamarlena immunohistochemicalexpressionofupregulatedgene4proteinexpressionurg4urgcpanditsassociationwith5yearsurvivalinpatientswithcolonadenocarcinoma
AT piecuchadam immunohistochemicalexpressionofupregulatedgene4proteinexpressionurg4urgcpanditsassociationwith5yearsurvivalinpatientswithcolonadenocarcinoma
AT michalskimarek immunohistochemicalexpressionofupregulatedgene4proteinexpressionurg4urgcpanditsassociationwith5yearsurvivalinpatientswithcolonadenocarcinoma
AT steplewskakatarzyna immunohistochemicalexpressionofupregulatedgene4proteinexpressionurg4urgcpanditsassociationwith5yearsurvivalinpatientswithcolonadenocarcinoma
AT matysiaknatalia immunohistochemicalexpressionofupregulatedgene4proteinexpressionurg4urgcpanditsassociationwith5yearsurvivalinpatientswithcolonadenocarcinoma
AT kucharzewskimarek immunohistochemicalexpressionofupregulatedgene4proteinexpressionurg4urgcpanditsassociationwith5yearsurvivalinpatientswithcolonadenocarcinoma