Membrane-Targeting Perylenylethynylphenols Inactivate Medically Important Coronaviruses via the Singlet Oxygen Photogeneration Mechanism

Perylenylethynyl derivatives have been recognized as broad-spectrum antivirals that target the lipid envelope of enveloped viruses. In this study, we present novel perylenylethynylphenols that exhibit nanomolar or submicromolar antiviral activity against Severe Acute Respiratory Syndrome Coronavirus...

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Detalles Bibliográficos
Autores principales: Mariewskaya, Kseniya A., Gvozdev, Daniil A., Chistov, Alexey A., Straková, Petra, Huvarová, Ivana, Svoboda, Pavel, Kotouček, Jan, Ivanov, Nikita M., Krasilnikov, Maxim S., Zhitlov, Mikhail Y., Pak, Alexandra M., Mikhnovets, Igor E., Nikitin, Timofei D., Korshun, Vladimir A., Alferova, Vera A., Mašek, Josef, Růžek, Daniel, Eyer, Luděk, Ustinov, Alexey V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10488391/
https://www.ncbi.nlm.nih.gov/pubmed/37687107
http://dx.doi.org/10.3390/molecules28176278

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