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The Complexity of Treatments and the Multidisciplinary Team—A Rare Case of Long-Term Progression—Free Survival in Prostate Cancer until Development of Liver and Brain Metastases

Introduction: Prostate cancer has no initial clinical manifestation in the case of brain metastases since they are asymptomatic at first. This is why there is a high risk for clinicians to overlook these lesions, and they are often confused with other diseases. With all the improvements in diagnosti...

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Autores principales: Rahnea-Nita, Roxana-Andreea, Rebegea, Laura-Florentina, Nechifor, Alexandru, Mareș, Cristian, Toma, Radu-Valeriu, Stoian, Alexandru-Rares, Ciuhu, Anda-Natalia, Andronache, Liliana-Florina, Constantin, Georgiana Bianca, Rahnea-Nita, Gabriela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10488423/
https://www.ncbi.nlm.nih.gov/pubmed/37685646
http://dx.doi.org/10.3390/jcm12175579
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author Rahnea-Nita, Roxana-Andreea
Rebegea, Laura-Florentina
Nechifor, Alexandru
Mareș, Cristian
Toma, Radu-Valeriu
Stoian, Alexandru-Rares
Ciuhu, Anda-Natalia
Andronache, Liliana-Florina
Constantin, Georgiana Bianca
Rahnea-Nita, Gabriela
author_facet Rahnea-Nita, Roxana-Andreea
Rebegea, Laura-Florentina
Nechifor, Alexandru
Mareș, Cristian
Toma, Radu-Valeriu
Stoian, Alexandru-Rares
Ciuhu, Anda-Natalia
Andronache, Liliana-Florina
Constantin, Georgiana Bianca
Rahnea-Nita, Gabriela
author_sort Rahnea-Nita, Roxana-Andreea
collection PubMed
description Introduction: Prostate cancer has no initial clinical manifestation in the case of brain metastases since they are asymptomatic at first. This is why there is a high risk for clinicians to overlook these lesions, and they are often confused with other diseases. With all the improvements in diagnostic technological methods, which allow the early detection of lesions, and the progress in terms of systemic therapy associated with increased survival, an increase in incidence has also been noticed. Materials and methods: We report the case of a 64-year-old patient who presented himself to the Oncology Department of “St. Luca” Chronic Disease Hospital in Bucharest in November 2011 and received the following diagnosis: biopsied prostate neoplasm, local-regionally advanced, pelvic lymph node metastases. Results: After receiving complex oncological treatment, this patient represents a rare case of long-term progression-free survival (15 years). Discussions: This case has some particularities. According to the literature data, survival with metastatic prostate cancer is approximately 21 months, and cerebral metastases are found in only 2% of prostate cancer cases. This case is one of the few cases in the specialty literature that benefited from all therapeutic sequences; namely, total androgenic blockade, docetaxel, abiraterone, enzalutamide, and cabazitaxel. Conclusions: Brain metastases are an unfavorable prognostic factor in prostate cancer. The therapeutic options developed in recent years allow the improvement of survival.
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spelling pubmed-104884232023-09-09 The Complexity of Treatments and the Multidisciplinary Team—A Rare Case of Long-Term Progression—Free Survival in Prostate Cancer until Development of Liver and Brain Metastases Rahnea-Nita, Roxana-Andreea Rebegea, Laura-Florentina Nechifor, Alexandru Mareș, Cristian Toma, Radu-Valeriu Stoian, Alexandru-Rares Ciuhu, Anda-Natalia Andronache, Liliana-Florina Constantin, Georgiana Bianca Rahnea-Nita, Gabriela J Clin Med Case Report Introduction: Prostate cancer has no initial clinical manifestation in the case of brain metastases since they are asymptomatic at first. This is why there is a high risk for clinicians to overlook these lesions, and they are often confused with other diseases. With all the improvements in diagnostic technological methods, which allow the early detection of lesions, and the progress in terms of systemic therapy associated with increased survival, an increase in incidence has also been noticed. Materials and methods: We report the case of a 64-year-old patient who presented himself to the Oncology Department of “St. Luca” Chronic Disease Hospital in Bucharest in November 2011 and received the following diagnosis: biopsied prostate neoplasm, local-regionally advanced, pelvic lymph node metastases. Results: After receiving complex oncological treatment, this patient represents a rare case of long-term progression-free survival (15 years). Discussions: This case has some particularities. According to the literature data, survival with metastatic prostate cancer is approximately 21 months, and cerebral metastases are found in only 2% of prostate cancer cases. This case is one of the few cases in the specialty literature that benefited from all therapeutic sequences; namely, total androgenic blockade, docetaxel, abiraterone, enzalutamide, and cabazitaxel. Conclusions: Brain metastases are an unfavorable prognostic factor in prostate cancer. The therapeutic options developed in recent years allow the improvement of survival. MDPI 2023-08-27 /pmc/articles/PMC10488423/ /pubmed/37685646 http://dx.doi.org/10.3390/jcm12175579 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Rahnea-Nita, Roxana-Andreea
Rebegea, Laura-Florentina
Nechifor, Alexandru
Mareș, Cristian
Toma, Radu-Valeriu
Stoian, Alexandru-Rares
Ciuhu, Anda-Natalia
Andronache, Liliana-Florina
Constantin, Georgiana Bianca
Rahnea-Nita, Gabriela
The Complexity of Treatments and the Multidisciplinary Team—A Rare Case of Long-Term Progression—Free Survival in Prostate Cancer until Development of Liver and Brain Metastases
title The Complexity of Treatments and the Multidisciplinary Team—A Rare Case of Long-Term Progression—Free Survival in Prostate Cancer until Development of Liver and Brain Metastases
title_full The Complexity of Treatments and the Multidisciplinary Team—A Rare Case of Long-Term Progression—Free Survival in Prostate Cancer until Development of Liver and Brain Metastases
title_fullStr The Complexity of Treatments and the Multidisciplinary Team—A Rare Case of Long-Term Progression—Free Survival in Prostate Cancer until Development of Liver and Brain Metastases
title_full_unstemmed The Complexity of Treatments and the Multidisciplinary Team—A Rare Case of Long-Term Progression—Free Survival in Prostate Cancer until Development of Liver and Brain Metastases
title_short The Complexity of Treatments and the Multidisciplinary Team—A Rare Case of Long-Term Progression—Free Survival in Prostate Cancer until Development of Liver and Brain Metastases
title_sort complexity of treatments and the multidisciplinary team—a rare case of long-term progression—free survival in prostate cancer until development of liver and brain metastases
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10488423/
https://www.ncbi.nlm.nih.gov/pubmed/37685646
http://dx.doi.org/10.3390/jcm12175579
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