Cargando…

Prevalence of Incidental Findings Suspicious for Transthyretin Cardiac Amyloidosis among Patients Undergoing Bone Scintigraphy: A Systematic Review and a Meta-Analysis

Background: The myocardial uptake of bone-seeking tracers suspicious for transthyretin cardiac amyloidosis (ATTR-CA) can be incidentally detected in patients undergoing bone scintigraphy for noncardiac reasons. We conducted a systematic review and meta-analysis to assess the prevalence of these scin...

Descripción completa

Detalles Bibliográficos
Autores principales: Treglia, Giorgio, Martinello, Chiara, Dondi, Francesco, Albano, Domenico, Bertagna, Francesco, Rizzo, Alessio, Delgado Bolton, Roberto C., Tersalvi, Gregorio, Muoio, Barbara, Riegger, Martin, Cecchin, Diego
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10488435/
https://www.ncbi.nlm.nih.gov/pubmed/37685765
http://dx.doi.org/10.3390/jcm12175698
_version_ 1785103474881462272
author Treglia, Giorgio
Martinello, Chiara
Dondi, Francesco
Albano, Domenico
Bertagna, Francesco
Rizzo, Alessio
Delgado Bolton, Roberto C.
Tersalvi, Gregorio
Muoio, Barbara
Riegger, Martin
Cecchin, Diego
author_facet Treglia, Giorgio
Martinello, Chiara
Dondi, Francesco
Albano, Domenico
Bertagna, Francesco
Rizzo, Alessio
Delgado Bolton, Roberto C.
Tersalvi, Gregorio
Muoio, Barbara
Riegger, Martin
Cecchin, Diego
author_sort Treglia, Giorgio
collection PubMed
description Background: The myocardial uptake of bone-seeking tracers suspicious for transthyretin cardiac amyloidosis (ATTR-CA) can be incidentally detected in patients undergoing bone scintigraphy for noncardiac reasons. We conducted a systematic review and meta-analysis to assess the prevalence of these scintigraphic findings. Methods: A comprehensive literature search was performed using two bibliographic databases (PubMed/MEDLINE and Cochrane Library), searching for articles related to the review question. Eligible articles were selected, and relevant data were extracted by two authors. The pooled prevalence of incidental findings suspicious for ATTR-CA among patients undergoing bone scintigraphy was calculated on a per-patient-based analysis using a random-effects model. The pooled measure was provided with 95% confidence interval (95% CI) values. Results: Among 219 records, 11 articles were selected for the systematic review and 10 for the meta-analysis. The pooled prevalence of incidental findings suspicious for ATTR-CA was 1.1% (95% CI: 0.7–1.4%) with heterogeneity due to the characteristics of the included studies, patients, and index tests. These findings are more prevalent in older men. Conclusions: The prevalence of incidental findings of ATTR-CA among patients undergoing bone scintigraphy is low but not negligible. Nuclear medicine physicians should suggest, in the scintigraphic report, further clinical investigations when these findings are detected. Prospective studies are warranted.
format Online
Article
Text
id pubmed-10488435
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-104884352023-09-09 Prevalence of Incidental Findings Suspicious for Transthyretin Cardiac Amyloidosis among Patients Undergoing Bone Scintigraphy: A Systematic Review and a Meta-Analysis Treglia, Giorgio Martinello, Chiara Dondi, Francesco Albano, Domenico Bertagna, Francesco Rizzo, Alessio Delgado Bolton, Roberto C. Tersalvi, Gregorio Muoio, Barbara Riegger, Martin Cecchin, Diego J Clin Med Review Background: The myocardial uptake of bone-seeking tracers suspicious for transthyretin cardiac amyloidosis (ATTR-CA) can be incidentally detected in patients undergoing bone scintigraphy for noncardiac reasons. We conducted a systematic review and meta-analysis to assess the prevalence of these scintigraphic findings. Methods: A comprehensive literature search was performed using two bibliographic databases (PubMed/MEDLINE and Cochrane Library), searching for articles related to the review question. Eligible articles were selected, and relevant data were extracted by two authors. The pooled prevalence of incidental findings suspicious for ATTR-CA among patients undergoing bone scintigraphy was calculated on a per-patient-based analysis using a random-effects model. The pooled measure was provided with 95% confidence interval (95% CI) values. Results: Among 219 records, 11 articles were selected for the systematic review and 10 for the meta-analysis. The pooled prevalence of incidental findings suspicious for ATTR-CA was 1.1% (95% CI: 0.7–1.4%) with heterogeneity due to the characteristics of the included studies, patients, and index tests. These findings are more prevalent in older men. Conclusions: The prevalence of incidental findings of ATTR-CA among patients undergoing bone scintigraphy is low but not negligible. Nuclear medicine physicians should suggest, in the scintigraphic report, further clinical investigations when these findings are detected. Prospective studies are warranted. MDPI 2023-09-01 /pmc/articles/PMC10488435/ /pubmed/37685765 http://dx.doi.org/10.3390/jcm12175698 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Treglia, Giorgio
Martinello, Chiara
Dondi, Francesco
Albano, Domenico
Bertagna, Francesco
Rizzo, Alessio
Delgado Bolton, Roberto C.
Tersalvi, Gregorio
Muoio, Barbara
Riegger, Martin
Cecchin, Diego
Prevalence of Incidental Findings Suspicious for Transthyretin Cardiac Amyloidosis among Patients Undergoing Bone Scintigraphy: A Systematic Review and a Meta-Analysis
title Prevalence of Incidental Findings Suspicious for Transthyretin Cardiac Amyloidosis among Patients Undergoing Bone Scintigraphy: A Systematic Review and a Meta-Analysis
title_full Prevalence of Incidental Findings Suspicious for Transthyretin Cardiac Amyloidosis among Patients Undergoing Bone Scintigraphy: A Systematic Review and a Meta-Analysis
title_fullStr Prevalence of Incidental Findings Suspicious for Transthyretin Cardiac Amyloidosis among Patients Undergoing Bone Scintigraphy: A Systematic Review and a Meta-Analysis
title_full_unstemmed Prevalence of Incidental Findings Suspicious for Transthyretin Cardiac Amyloidosis among Patients Undergoing Bone Scintigraphy: A Systematic Review and a Meta-Analysis
title_short Prevalence of Incidental Findings Suspicious for Transthyretin Cardiac Amyloidosis among Patients Undergoing Bone Scintigraphy: A Systematic Review and a Meta-Analysis
title_sort prevalence of incidental findings suspicious for transthyretin cardiac amyloidosis among patients undergoing bone scintigraphy: a systematic review and a meta-analysis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10488435/
https://www.ncbi.nlm.nih.gov/pubmed/37685765
http://dx.doi.org/10.3390/jcm12175698
work_keys_str_mv AT tregliagiorgio prevalenceofincidentalfindingssuspiciousfortransthyretincardiacamyloidosisamongpatientsundergoingbonescintigraphyasystematicreviewandametaanalysis
AT martinellochiara prevalenceofincidentalfindingssuspiciousfortransthyretincardiacamyloidosisamongpatientsundergoingbonescintigraphyasystematicreviewandametaanalysis
AT dondifrancesco prevalenceofincidentalfindingssuspiciousfortransthyretincardiacamyloidosisamongpatientsundergoingbonescintigraphyasystematicreviewandametaanalysis
AT albanodomenico prevalenceofincidentalfindingssuspiciousfortransthyretincardiacamyloidosisamongpatientsundergoingbonescintigraphyasystematicreviewandametaanalysis
AT bertagnafrancesco prevalenceofincidentalfindingssuspiciousfortransthyretincardiacamyloidosisamongpatientsundergoingbonescintigraphyasystematicreviewandametaanalysis
AT rizzoalessio prevalenceofincidentalfindingssuspiciousfortransthyretincardiacamyloidosisamongpatientsundergoingbonescintigraphyasystematicreviewandametaanalysis
AT delgadoboltonrobertoc prevalenceofincidentalfindingssuspiciousfortransthyretincardiacamyloidosisamongpatientsundergoingbonescintigraphyasystematicreviewandametaanalysis
AT tersalvigregorio prevalenceofincidentalfindingssuspiciousfortransthyretincardiacamyloidosisamongpatientsundergoingbonescintigraphyasystematicreviewandametaanalysis
AT muoiobarbara prevalenceofincidentalfindingssuspiciousfortransthyretincardiacamyloidosisamongpatientsundergoingbonescintigraphyasystematicreviewandametaanalysis
AT rieggermartin prevalenceofincidentalfindingssuspiciousfortransthyretincardiacamyloidosisamongpatientsundergoingbonescintigraphyasystematicreviewandametaanalysis
AT cecchindiego prevalenceofincidentalfindingssuspiciousfortransthyretincardiacamyloidosisamongpatientsundergoingbonescintigraphyasystematicreviewandametaanalysis