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Interrelationships between Peak Strain Dispersion, Myocardial Work Indices, Isovolumetric Relaxation and Systolic–Diastolic Coupling in Middle-Aged Healthy Subjects
In echocardiography, peak strain dispersion (PSD) is the standard deviation of the time to peak longitudinal strain for each left ventricular (LV) segment during systole. It assesses the coordination and synchrony of LV segment contractility. Global work efficiency (GWE) and global wasted work (GWW)...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10488442/ https://www.ncbi.nlm.nih.gov/pubmed/37685690 http://dx.doi.org/10.3390/jcm12175623 |
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author | Minczykowski, Andrzej Guzik, Przemysław Sajkowska, Anna Pałasz-Borkowska, Anna Wykrętowicz, Andrzej |
author_facet | Minczykowski, Andrzej Guzik, Przemysław Sajkowska, Anna Pałasz-Borkowska, Anna Wykrętowicz, Andrzej |
author_sort | Minczykowski, Andrzej |
collection | PubMed |
description | In echocardiography, peak strain dispersion (PSD) is the standard deviation of the time to peak longitudinal strain for each left ventricular (LV) segment during systole. It assesses the coordination and synchrony of LV segment contractility. Global work efficiency (GWE) and global wasted work (GWW) quantify LV myocardial work and, if impaired, the coupling between LV systolic contraction and early relaxation. Isovolumetric relaxation (IVRT) measures the duration of initial LV relaxation, while the ratio of early diastolic recoil to systolic excursion (E′(VTI)/S′(VTI)) describes systolic–diastolic coupling. We evaluated these parameters in 69 healthy subjects and found that PSD correlated negatively with GWE (r = −0.49, p < 0.0001) and E′(VTI)/S′(VTI) (r = −0.44, p = 0.0002), but positively with GWW (r = 0.4, p = 0.0007) and IVRT (r = 0.53, p < 0.0001). GWE correlated negatively with GWW (r = −0.94, p < 0.0001) and IVRT (r = −0.30, p = 0.0127), but positively with E′(VTI)/S′(VTI) (r = 0.3, p = 0.0132). In addition, E′(VTI)/S′(VTI) was negatively correlated with GWW (r = −0.35, p = 0.0032) and IVRT (r = −0.36, p = 0.0024). These associations remained significant after adjustment for sex, age and LV mass index of the subjects. In conclusion, there is an interaction between measures of LV asynchrony, myocardial work, diastolic function and its systolic–diastolic coupling in middle-aged healthy subjects. The clinical value of these interactions requires further investigation. |
format | Online Article Text |
id | pubmed-10488442 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-104884422023-09-09 Interrelationships between Peak Strain Dispersion, Myocardial Work Indices, Isovolumetric Relaxation and Systolic–Diastolic Coupling in Middle-Aged Healthy Subjects Minczykowski, Andrzej Guzik, Przemysław Sajkowska, Anna Pałasz-Borkowska, Anna Wykrętowicz, Andrzej J Clin Med Article In echocardiography, peak strain dispersion (PSD) is the standard deviation of the time to peak longitudinal strain for each left ventricular (LV) segment during systole. It assesses the coordination and synchrony of LV segment contractility. Global work efficiency (GWE) and global wasted work (GWW) quantify LV myocardial work and, if impaired, the coupling between LV systolic contraction and early relaxation. Isovolumetric relaxation (IVRT) measures the duration of initial LV relaxation, while the ratio of early diastolic recoil to systolic excursion (E′(VTI)/S′(VTI)) describes systolic–diastolic coupling. We evaluated these parameters in 69 healthy subjects and found that PSD correlated negatively with GWE (r = −0.49, p < 0.0001) and E′(VTI)/S′(VTI) (r = −0.44, p = 0.0002), but positively with GWW (r = 0.4, p = 0.0007) and IVRT (r = 0.53, p < 0.0001). GWE correlated negatively with GWW (r = −0.94, p < 0.0001) and IVRT (r = −0.30, p = 0.0127), but positively with E′(VTI)/S′(VTI) (r = 0.3, p = 0.0132). In addition, E′(VTI)/S′(VTI) was negatively correlated with GWW (r = −0.35, p = 0.0032) and IVRT (r = −0.36, p = 0.0024). These associations remained significant after adjustment for sex, age and LV mass index of the subjects. In conclusion, there is an interaction between measures of LV asynchrony, myocardial work, diastolic function and its systolic–diastolic coupling in middle-aged healthy subjects. The clinical value of these interactions requires further investigation. MDPI 2023-08-28 /pmc/articles/PMC10488442/ /pubmed/37685690 http://dx.doi.org/10.3390/jcm12175623 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Minczykowski, Andrzej Guzik, Przemysław Sajkowska, Anna Pałasz-Borkowska, Anna Wykrętowicz, Andrzej Interrelationships between Peak Strain Dispersion, Myocardial Work Indices, Isovolumetric Relaxation and Systolic–Diastolic Coupling in Middle-Aged Healthy Subjects |
title | Interrelationships between Peak Strain Dispersion, Myocardial Work Indices, Isovolumetric Relaxation and Systolic–Diastolic Coupling in Middle-Aged Healthy Subjects |
title_full | Interrelationships between Peak Strain Dispersion, Myocardial Work Indices, Isovolumetric Relaxation and Systolic–Diastolic Coupling in Middle-Aged Healthy Subjects |
title_fullStr | Interrelationships between Peak Strain Dispersion, Myocardial Work Indices, Isovolumetric Relaxation and Systolic–Diastolic Coupling in Middle-Aged Healthy Subjects |
title_full_unstemmed | Interrelationships between Peak Strain Dispersion, Myocardial Work Indices, Isovolumetric Relaxation and Systolic–Diastolic Coupling in Middle-Aged Healthy Subjects |
title_short | Interrelationships between Peak Strain Dispersion, Myocardial Work Indices, Isovolumetric Relaxation and Systolic–Diastolic Coupling in Middle-Aged Healthy Subjects |
title_sort | interrelationships between peak strain dispersion, myocardial work indices, isovolumetric relaxation and systolic–diastolic coupling in middle-aged healthy subjects |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10488442/ https://www.ncbi.nlm.nih.gov/pubmed/37685690 http://dx.doi.org/10.3390/jcm12175623 |
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