Cargando…

Primary Hemostasis Disorders as a Cause of Heavy Menstrual Bleeding in Women of Reproductive Age

Heavy menstrual bleeding (HMB) is a common clinical condition affecting adolescent and adult women and compromising their quality of life. Primary hemostasis disorders, affecting platelet plug formation, can be the underlying cause of HMB. They comprise a heterogeneous group of diseases with Von Wil...

Descripción completa

Detalles Bibliográficos
Autores principales: Kontogiannis, Athanasios, Matsas, Alkis, Valsami, Serena, Livanou, Maria Effrosyni, Panoskaltsis, Theodoros, Christopoulos, Panagiotis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10488471/
https://www.ncbi.nlm.nih.gov/pubmed/37685769
http://dx.doi.org/10.3390/jcm12175702
_version_ 1785103483646509056
author Kontogiannis, Athanasios
Matsas, Alkis
Valsami, Serena
Livanou, Maria Effrosyni
Panoskaltsis, Theodoros
Christopoulos, Panagiotis
author_facet Kontogiannis, Athanasios
Matsas, Alkis
Valsami, Serena
Livanou, Maria Effrosyni
Panoskaltsis, Theodoros
Christopoulos, Panagiotis
author_sort Kontogiannis, Athanasios
collection PubMed
description Heavy menstrual bleeding (HMB) is a common clinical condition affecting adolescent and adult women and compromising their quality of life. Primary hemostasis disorders, affecting platelet plug formation, can be the underlying cause of HMB. They comprise a heterogeneous group of diseases with Von Willebrand disease (VWD) being the most commonly diagnosed; other disorders in this group that have been linked to HMB include (a) Glanzmann thrombasthenia, (b) Bernard–Soulier syndrome, (c) Hermansky–Pudlak syndrome, (d) immune thrombocytopenia (ITP), and (e) Ehlers–Danlos syndromes (EDS) and hypermobility spectrum disorders (HSD). Diagnosing these diseases can be challenging, as the basic laboratory investigations can be within the normal range. Thus, identification of specific clinical features and a thorough hematologic workup can be very important, providing the correct diagnosis. Proper diagnosis of the underlying disorder is important, as management may vary accordingly. Although disease-specific management guidelines exist for some of these disorders such as VWD and ITP, due to the rarity of most primary hemostasis disorders, the best approach for the management of HMB in these women remains elusive. The goal of this study was to create an informative, comprehensive review of the primary hemostasis disorders that have been linked to HMB. This study provides a summary of the basic published information regarding epidemiology, pathophysiology, clinical phenotype, diagnosis, and treatment of HMB in those diseases and serves as a reference guide for further reading.
format Online
Article
Text
id pubmed-10488471
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-104884712023-09-09 Primary Hemostasis Disorders as a Cause of Heavy Menstrual Bleeding in Women of Reproductive Age Kontogiannis, Athanasios Matsas, Alkis Valsami, Serena Livanou, Maria Effrosyni Panoskaltsis, Theodoros Christopoulos, Panagiotis J Clin Med Review Heavy menstrual bleeding (HMB) is a common clinical condition affecting adolescent and adult women and compromising their quality of life. Primary hemostasis disorders, affecting platelet plug formation, can be the underlying cause of HMB. They comprise a heterogeneous group of diseases with Von Willebrand disease (VWD) being the most commonly diagnosed; other disorders in this group that have been linked to HMB include (a) Glanzmann thrombasthenia, (b) Bernard–Soulier syndrome, (c) Hermansky–Pudlak syndrome, (d) immune thrombocytopenia (ITP), and (e) Ehlers–Danlos syndromes (EDS) and hypermobility spectrum disorders (HSD). Diagnosing these diseases can be challenging, as the basic laboratory investigations can be within the normal range. Thus, identification of specific clinical features and a thorough hematologic workup can be very important, providing the correct diagnosis. Proper diagnosis of the underlying disorder is important, as management may vary accordingly. Although disease-specific management guidelines exist for some of these disorders such as VWD and ITP, due to the rarity of most primary hemostasis disorders, the best approach for the management of HMB in these women remains elusive. The goal of this study was to create an informative, comprehensive review of the primary hemostasis disorders that have been linked to HMB. This study provides a summary of the basic published information regarding epidemiology, pathophysiology, clinical phenotype, diagnosis, and treatment of HMB in those diseases and serves as a reference guide for further reading. MDPI 2023-09-01 /pmc/articles/PMC10488471/ /pubmed/37685769 http://dx.doi.org/10.3390/jcm12175702 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kontogiannis, Athanasios
Matsas, Alkis
Valsami, Serena
Livanou, Maria Effrosyni
Panoskaltsis, Theodoros
Christopoulos, Panagiotis
Primary Hemostasis Disorders as a Cause of Heavy Menstrual Bleeding in Women of Reproductive Age
title Primary Hemostasis Disorders as a Cause of Heavy Menstrual Bleeding in Women of Reproductive Age
title_full Primary Hemostasis Disorders as a Cause of Heavy Menstrual Bleeding in Women of Reproductive Age
title_fullStr Primary Hemostasis Disorders as a Cause of Heavy Menstrual Bleeding in Women of Reproductive Age
title_full_unstemmed Primary Hemostasis Disorders as a Cause of Heavy Menstrual Bleeding in Women of Reproductive Age
title_short Primary Hemostasis Disorders as a Cause of Heavy Menstrual Bleeding in Women of Reproductive Age
title_sort primary hemostasis disorders as a cause of heavy menstrual bleeding in women of reproductive age
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10488471/
https://www.ncbi.nlm.nih.gov/pubmed/37685769
http://dx.doi.org/10.3390/jcm12175702
work_keys_str_mv AT kontogiannisathanasios primaryhemostasisdisordersasacauseofheavymenstrualbleedinginwomenofreproductiveage
AT matsasalkis primaryhemostasisdisordersasacauseofheavymenstrualbleedinginwomenofreproductiveage
AT valsamiserena primaryhemostasisdisordersasacauseofheavymenstrualbleedinginwomenofreproductiveage
AT livanoumariaeffrosyni primaryhemostasisdisordersasacauseofheavymenstrualbleedinginwomenofreproductiveage
AT panoskaltsistheodoros primaryhemostasisdisordersasacauseofheavymenstrualbleedinginwomenofreproductiveage
AT christopoulospanagiotis primaryhemostasisdisordersasacauseofheavymenstrualbleedinginwomenofreproductiveage